Research Summary
Dr. Wolfgang's laboratory studies the role and regulation of cellular and organismal metabolism. The research in the Wolfgang laboratory utilizes biochemistry and molecular genetics to understand the molecular mechanisms used to sense and respond to nutritional/metabolic cues. They are particularly interested in deciphering the roles of unexplored metabolic enzymes/pathways and determining novel roles of cannonical metabolic pathways in under-explored cells and tissues.
Selected Publications
Selen ES, Choi J, Wolfgang MJ. "Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease." JCI Insight 2021; 34:108869
Bowman CE, Selen Alpergin ES, Cavagnini K, Smith DM, Scafidi S, Wolfgang MJ. "Maternal lipid metabolism directs fetal liver programming following nutrient stress." Cell Reports 2019; 29:1299-1310
Lee J, Choi J, Selen Alpergin ES, Zhao L, Hartung T, Scafidi S, Riddle RC, Wolfgang MJ. "Loss of hepatic mitochondrial long chain fatty acid oxidation confers resistance to diet-induced obesity and glucose intolerance." Cell Reports 2017; 20:655-667
Bowman CE, Rodriguez S,Selen-Alpergin E, Acoba MG, Zhao L, Hartung T, Claypool SM, Watkins PA, Wolfgang MJ. "The mammalian malonyl-CoA synthetase ACSF3 is required for mitochondrial protein malonylation and metabolic efficiency." Cell Chemical Biology 2017; 24:673-684
Lee J, Choi J, Scafidi S, Wolfgang MJ. "Hepatic fatty acid oxidation restrains systemic catabolism during starvation." Cell Reports 2016: 16: 201-212
Bowman CE, Zhao L, Hartung T, Wolfgang MJ. "Requirement for the mitochondrial pyruvate carrier in mammalian development revealed by a hypomorphic allelic series." Mol Cell Biol 2016; 36(15):2089-2104
Lee J, Choi J, Aja S, Scafidi S, Wolfgang MJ. "Loss of adipose fatty acid oxidation does not potentiate obesity at thermoneutrality." Cell Reports 2016; 14:1308-1316
Nomura M, Liu J, Rovira IL, Gonzalez-Hurtado E, Lee J, Wolfgang MJ*, Finkel T.* "The role of fatty acid oxidation in macrophage polarization." Nature Immunology 2016; 17(3): 216-217. (*Co-corresponding authors)
Lee J, Ellis JM, Wolfgang MJ. "Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress induced inflammation." Cell Reports 2015; 10(2): 266-279
Ellis JM, Wong GW, Wolfgang MJ. “Acyl Coenzyme A Thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity.” Mol Cell Biol. 2013; 33(9) 1869-1882
