Matt Merguerian, M.D., Ph.D.

Matthew Douglas Merguerian, M.D., Ph.D.

Headshot of Matt Merguerian
  • Instructor of Pediatrics

Specializes in: Adolescents (12-18 years), Children (1-11 years), Infants (up to 1 year)


Anemias, Bleeding Disorders, Bone Marrow Failure, Hypercoagulable States, Inherited Hematologic Malignancies, Pediatric Hematology, Platelet Function Disorders, Thrombocytopenias more

Research Interests

Platelet Function Disorders; Inherited Thrombocytopenias; Bone Marrow Failure Syndromes more


Dr. Matthew Merguerian is a pediatric hematologist at the Johns Hopkins University School of Medicine specializing in platelet disorders. He researches genetic variants that cause inherited bleeding disorders that result from platelet dysfunction. His lab is interested in understanding the mechanism behind the platelet dysfunction and in developing proteins that can therapeutically alter platelet reactivity for disorders of bleeding and thrombosis.

Matt grew up in Toms River, NJ.  As an undergraduate at the University of Chicago, he worked in the lab of Dr. Shohei Koide using NMR spectroscopy to study how proteins bind to each other and how point mutations could interfere with this binding. Matt was then selected for an NIH NIGMS-funded spot in the Medical Scientist Training Program at Columbia University in New York City. There, he earned his medical degree at the Columbia College of Physicians and Surgeons, and he completed his doctoral studies in the laboratory of Dr. Virginia Cornish in the Department of Chemistry. In his doctoral research, he engineered a genetic system in yeast that could produce useful new binding proteins through a process of directed evolution. Dr. Merguerian then moved to New Haven, CT, where he trained in pediatrics as a resident at the Yale School of Medicine. He spent a research elective in the laboratory of Dr. Patrick Gallagher studying the GATA1 transcription factor. Dr. Merguerian then trained as a fellow in pediatric hematology/oncology at the combined Johns Hopkins / NIH program. At the NIH in Bethesda, MD, he worked in the lab of Dr. Paul Liu at the National Human Genome Research Institute (NHGRI). He is an associate investigator on the NIH natural history study of families with germline RUNX1 mutation, a condition which causes thrombocytopenia, platelet dysfunction, and increased risk of developing hematologic malignancy.

Dr. Merguerian has held a medical license in the state of Maryland since 2017. more


  • Instructor of Pediatrics

Departments / Divisions

Centers & Institutes



  • MD PhD; Columbia University College of Physicians and Surgeons (2014)


  • Pediatrics; Yale-New Haven Hospital (2017)


  • Pediatric Hematology-Oncology; Johns Hopkins University School of Medicine (2020)
  • Pediatric Hematology-Oncology; National Institutes of Health (2021)

Board Certifications

  • American Board of Pediatrics (Pediatric Hematology-Oncology) (2023)
  • American Board of Pediatrics (Pediatrics) (2018)

Research & Publications

Research Summary

Dr. Merguerian's research focuses on genetic diseases that affect the production and function of platelets.

Clinical Trial Keywords

Germline RUNX1 Deficiency; Familial Platelet Disorder

Clinical Trials

Longitudinal Studies of Patient With FPDMM Identifier: NCT03854318

Contact for Research Inquiries

720 Rutland Avenue
Ross 1125
Baltimore, MD 21205 map
Phone: 410-955-6132
Fax: 570-473-5316

Academic Affiliations & Courses

Courses and Syllabi

  • Organic Chemistry
    Columbia University, New York, NY
    2008 - 2008

Activities & Honors


  • Physician Scientist Training Program Scholar, Johns Hopkins University, 2018
  • Medical Scientist Training Program, NIH NIGMS, 2008 - 2011
  • Frances E. Knock Prize for Outstanding Academic Achievement in Chemistry, University of Chicago, 2006
  • Howard Hughes Undergraduate Summer Research Fellowship, HHMI, 2004
  • Robert C. Byrd Honors Scholarship, U.S. Dept. of Ed., 2002
  • Dean's List, University of Chicago, 2003 - 2006


  • American Academy of Pediatrics, 2017

    Fellow of the AAP

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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