Dr. Matthew Merguerian is an instructor of pediatrics at the Johns Hopkins University School of Medicine.
As a special volunteer at the NIH in Bethesda, MD, he continues the research he started as a fellow in the laboratory of Dr. Paul Liu at the National Human Genome Research Institute. He is an associate investigator on the NIH natural history study of families with germline RUNX1 mutation, a condition which causes thrombocytopenia, platelet dysfunction, and increased risk of developing hematologic malignancy. He is also studying how gene mutations affect the development of myeloid leukemia in a mouse model of inversion(16) leukemia.
Matthew grew up in Toms River, NJ. He attended the University of Chicago as an undergraduate, finishing in 2006 with concentrations in chemistry and biology. As an undergraduate researcher in the lab of Dr. Shohei Koide, Matthew studied how proteins bind to each other using NMR spectroscopy, and how point mutations could interfere with binding function. Matthew was then selected for an NIH NIGMS-funded spot in the Medical Scientist Training Program at Columbia University in New York City. There he earned his medical degree at the Columbia College of Physicians and Surgeons, and he completed his doctoral studies in the laboratory of Dr. Virginia Cornish in the Department of Chemistry. In his doctoral research, he engineered a genetic system in yeast that could discover useful new binding proteins through a process of directed evolution. Dr. Merguerian then moved to New Haven, CT, where he trained in pediatrics as a resident at the Yale School of Medicine. He spent a research elective in the laboratory of Dr. Patrick Gallagher studying the GATA1 transcription factor. Dr. Merguerian then trained as a fellow in pediatric hematology/oncology at the combined Johns Hopkins / NIH program. In 2021, he joined the faculty of the Division of Pediatric Hematology in the Department of Pediatrics at the Johns Hopkins University School of Medicine.
Dr. Merguerian has been a board-certified pediatrician since 2018 and has held a medical license in the state of Maryland since 2017.
Dr. Merguerian lives in Baltimore, MD, with his wife and two sons.