Dr. Matthew Merguerian is a pediatric hematologist at the Johns Hopkins University School of Medicine specializing in platelet disorders. He researches genetic variants that cause inherited bleeding disorders that result from platelet dysfunction. His lab is interested in understanding the mechanism behind the platelet dysfunction and in developing proteins that can therapeutically alter platelet reactivity for disorders of bleeding and thrombosis.
Matt grew up in Toms River, NJ. As an undergraduate at the University of Chicago, he worked in the lab of Dr. Shohei Koide using NMR spectroscopy to study how proteins bind to each other and how point mutations could interfere with this binding. Matt was then selected for an NIH NIGMS-funded spot in the Medical Scientist Training Program at Columbia University in New York City. There, he earned his medical degree at the Columbia College of Physicians and Surgeons, and he completed his doctoral studies in the laboratory of Dr. Virginia Cornish in the Department of Chemistry. In his doctoral research, he engineered a genetic system in yeast that could produce useful new binding proteins through a process of directed evolution. Dr. Merguerian then moved to New Haven, CT, where he trained in pediatrics as a resident at the Yale School of Medicine. He spent a research elective in the laboratory of Dr. Patrick Gallagher studying the GATA1 transcription factor. Dr. Merguerian then trained as a fellow in pediatric hematology/oncology at the combined Johns Hopkins / NIH program. At the NIH in Bethesda, MD, he worked in the lab of Dr. Paul Liu at the National Human Genome Research Institute (NHGRI). He is an associate investigator on the NIH natural history study of families with germline RUNX1 mutation, a condition which causes thrombocytopenia, platelet dysfunction, and increased risk of developing hematologic malignancy.
Dr. Merguerian has held a medical license in the state of Maryland since 2017.