Matthew Michael Ippolito, M.D., Ph.D.

Headshot of Matthew Michael Ippolito
  • Assistant Professor of Medicine


Clinical Pharmacology, Infectious Disease, Malaria more


Matthew Ippolito, M.D., Ph.D. is an Assistant Professor of Medicine and the Director of Clinical Epidemiology for the Southern and Central Africa International Centers of Excellence for Malaria Research (ICEMR). He received his A.B. from Dartmouth College and his M.D. from the Geisel School of Medicine at Dartmouth. He completed his Internal Medicine Internship and Residency at the University of California, San Francisco, and fellowships in Infectious Diseases and Clinical Pharmacology at the Johns Hopkins University School of Medicine where he received his Ph.D. in Clinical Investigation from the Johns Hopkins Bloomberg School of Public Health. He also served in the Peace Corps in Ghana, West Africa.

Dr. Ippolito specializes in global health and tropical infectious diseases with a research focus on malaria in sub-Saharan Africa. His NIH-supported research program explores the clinical pharmacology of antimalarial drugs and the genetic epidemiology of drug resistance. In his role as Director of Clinical Epidemiology for the Southern and Central Africa ICEMR, Dr. Ippolito designs and oversees clinical, translational, and epidemiological studies of malaria. Dr. Ippolito also serves as a Phase I and II clinical trialist for the LONGEVITY consortium, established to develop and deploy long-acting nanoformulations of essential anti-infective drugs. He is also a co-developer of a computer vision-based machine learning platform for malaria diagnostic and research applications, and serves on the editorial board of Frontiers in Malaria more


  • Assistant Professor of Medicine
  • Assistant Professor of Pharmacology and Molecular Sciences

Departments / Divisions



  • MD; Geisel School of Medicine at Dartmouth (2011)


  • Internal Medicine; University of California San Francisco School of Medicine (2014)


  • Infectious Diseases; Johns Hopkins University School of Medicine (2017)
  • Clinical Pharmacology; Johns Hopkins University School of Medicine (2018)

Board Certifications

  • American Board of Internal Medicine (Infectious Disease) (2016)
  • American Board of Internal Medicine (Internal Medicine) (2014)

Research & Publications

Selected Publications

View all on PubMed

Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, Shanks GD, Slutsker L, Kachur SP, Wegbreit J, Ippolito MM, Poirot E, Gosling RD. “Review of mass drug administration for malaria and its operational challenges.” America Journal of Tropical Medicine and Hygiene. 2015;93(1):125-134.

Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T, Rosenthal P. “The relative impact of artemether-lumefantrine compared to non-artemisinin antimalarials on gametocyte carriage and transmission of falciparum malaria: a systematic-review and meta-analysis.” Clinical Infectious Diseases. 2017;65(3):486-494. 

Ippolito MM, Kamavu L, Kabuya J, Tente C, Wapachole M, Chileshe E, Thuma P, Muleba M, Chaponda M, Mulenga M, Moss WJ. “Risk factors for mortality in children hospitalized with severe malaria in northern Zambia: a retrospective case-control study.” American Journal of Tropical Medicine and Hygiene. 2018 Jun;98(6):1699-1704.

Ippolito MM, Moser KA, Kabuya JB, Cunningham C, Juliano JJ. “Antimalarial drug resistance and implications for the WHO Global Technical Strategy.” Curr Epidemiol Rep. 2021; 8:46-62.

Ippolito MM, Kabuya JB, Hauser M, Kamavu LK, Banda PM, Yanek LR, Malik R, Mulenga M, Bailey JA, Chongwe G, Louis TA, Shapiro TA, Moss WJ. "Whole blood transfusion for severe malarial anemia in a high Plasmodium falciparum transmission setting." Clin Infect Dis. 2022 Apr 19 ePub ahead of print.

Activities & Honors


  • Alpha Omega Alpha
  • Albert Schweitzer Fellow
  • Delta Omega Public Health Honorary Society


  • American Society of Tropical Medicine and Hygiene
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