Mark Luciano, M.D., Ph.D.

Mark Gregory Luciano, M.D., Ph.D.

Headshot of Mark Luciano
  • Director of the Hydrocephalus and Cerebral Fluid Center
  • Professor of Neurosurgery


Cerebral Cyst, Cerebrospinal Fluid (CSF) Leaks, Chiari Malformations, Hydrocephalus, Intracranial Hypertension, Neurological Surgery, Pseudotumor Cerebri (Idiopathic Intracranial Hypertension), Spinal Cysts more

Research Interests

Hydrocephalus; cerebrovascular function; cerebral blood flow; Chiari malformation more

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Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital

Appointment Phone: 410-955-6406
600 N. Wolfe Street
Phipps Suite 126
Baltimore, MD 21287
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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-955-6406
301 Mason Lord Drive
Baltimore, MD 21224
Johns Hopkins Bayview Medical Center - Google Maps


Dr. Mark Luciano is the director of the Johns Hopkins Hydrocephalus and Cerebral Fluid Center. A renowned leader in treating hydrocephalus, Dr. Luciano is distinguished both nationally and internationally for his research and educational and clinical work in neuroendoscopy.

Dr. Luciano treats adults with hydrocephalus, pseudotumor cerebri, intracranial hypotension, Chiari malformations, and cerebral and spinal cysts. He has significant expertise treating children and adults with cerebrospinal fluid leaks and congenital disorders.
Among his accomplishments in neuroscience research and biomedical engineering are his investigation of the cerebrovascular response to hydrocephalus and the invention of a unique device for control of intracranial pressure (ICP) pulsatility to increase blood flow. His National Institutes of Health-funded studies have explored prolonged compression and hypoxia in the brain as a result of hydrocephalus, as well as the interaction between cerebrospinal fluid and vascular systems. more


  • Director of the Hydrocephalus and Cerebral Fluid Center
  • The Berry-Brem Professor in Neurosurgery
  • Professor of Neurosurgery
  • Professor of Biomedical Engineering
  • Professor of Pediatrics

Departments / Divisions



  • MD; University of Chicago Pritzker School of Medicine (1985)


  • Neurosurgery; Hospital of the University of Pennsylvania (1992)


  • Pediatric Neurosurgery; Boston Children's Hospital (1993)

Board Certifications

  • American Board of Neurological Surgery (Neurological Surgery) (1998)

Research & Publications


Continuation Device for increasing CBF through cardiac-gaited cranial volume alteration
Patent # US12/090,640 | 01/01/2015

Device for increasing CBF through cardiac-gaited cranial volume alteration
Patent # US12/770,276 | 01/01/2015

Activities & Honors


  • World Neurosurgery, 2015

    Section Editor, Hydrocephalus and CSF Disorders

  • Chiari and Syringomyelia Foundation, 2013

    Medical Advisory Board, Vice Chair

  • Adult Hydrocephalus Clinical Research Network, 2010
  • International Hydrocephalus Research Society, 2008
  • Hydrocephalus Association, 2005

    Medical Advisory Board

Videos & Media

Recent News Articles and Media Coverage

Holistic Treatment for CSF Disorders, NeuroLogic (Fall 2015)

Comprehensive Treatment for CSF Disorders Johns Hopkins Bayview Health & Wellness (Feb. 1, 2016)

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