Research Summary
Dr. Halushka’s laboratory is currently working to identify biomarkers of sudden cardiac death and expression patterns of microRNAs in tissues and cells. MicroRNAs are key post-translational regulators of genes. He is interested in determining how microRNAs are altered in human diseases.
His laboratory is also involved in a number of collaborative projects relating to cardiovascular diseases such as sudden cardiac death, cardiac citrullination and neonatal lupus.
Lab
Lab Website: Halushka Laboratory
Selected Publications
View all on PubMed
Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Cardiovasc Pathol. 2016 May-Jun;25(3):247-57. doi: 10.1016/j.carpath.2016.03.002. Epub 2016 Mar 12. Review. PMID: 27031798
A benchmark for microRNA quantification algorithms using the OpenArray platform. McCall MN, Baras AS, Crits-Christoph A, Ingersoll R, McAlexander MA, Witwer KW, Halushka MK. BMC Bioinformatics. 2016 Mar 22;17:138. doi: 10.1186/s12859-016-0987-8.
miRge - A Multiplexed Method of Processing Small RNA-Seq Data to Determine MicroRNA Entropy. Baras AS, Mitchell CJ, Myers JR, Gupta S, Weng LC, Ashton JM, Cornish TC, Pandey A, Halushka MK. PLoS One. 2015 Nov 16;10(11):e0143066. doi: 10.1371/journal.pone.0143066. eCollection 2015. PMID: 26571139
Extracellular vesicle microRNA transfer in cardiovascular disease. Das S, Halushka MK. Cardiovasc Pathol. 2015 Jul-Aug;24(4):199-206. doi: 10.1016/j.carpath.2015.04.007. Epub 2015 Apr 28. Review. PMID: 25958013
A draft map of the human proteome. Kim MS, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, Madugundu AK, Kelkar DS, Isserlin R, Jain S, Thomas JK, Muthusamy B, Leal-Rojas P, Kumar P, Sahasrabuddhe NA, Balakrishnan L, Advani J, George B, Renuse S, Selvan LD, Patil AH, Nanjappa V, Radhakrishnan A, Prasad S, Subbannayya T, Raju R, Kumar M, Sreenivasamurthy SK, Marimuthu A, Sathe GJ, Chavan S, Datta KK, Subbannayya Y, Sahu A, Yelamanchi SD, Jayaram S, Rajagopalan P, Sharma J, Murthy KR, Syed N, Goel R, Khan AA, Ahmad S, Dey G, Mudgal K, Chatterjee A, Huang TC, Zhong J, Wu X, Shaw PG, Freed D, Zahari MS, Mukherjee KK, Shankar S, Mahadevan A, Lam H, Mitchell CJ, Shankar SK, Satishchandra P, Schroeder JT, Sirdeshmukh R, Maitra A, Leach SD, Drake CG, Halushka MK, Prasad TS, Hruban RH, Kerr CL, Bader GD, Iacobuzio-Donahue CA, Gowda H, Pandey A. Nature. 2014 May 29;509(7502):575-81. doi: 10.1038/nature13302. PMID: 24870542
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