Biologically relevant chemical mechanisms of nucleic acid damage and repair; design and characterization of DNA repair enzyme inhibitors and radiosensitizing agents; biotechnology ...read more
Rapid DNA-Protein Cross-linking and Strand Scission by an Abasic Site in a Nucleosome Core Particle. Sczepanski, J. T.; Wong, R. S.; McKnight, J. N.; Bowman, G. D.; Greenberg,, M. M. Proc. Natl. Acad. Sci. USA 2010, 107, 22475-22480. (PMC: 3012510)
A Novel Mechanism for the Formation of Direct Strand Breaks Upon Anaerobic Photolysis of Duplex DNA Containing 5-Bromodeoxyuridine. Cook, G. P.; Greenberg, M. M. J. Am. Chem. Soc. 1996, 118, 10025.
Synthesis and Characterization of Oligodeoxynucleotides Containing Formamidopyrimidine Lesions and Nonhydrolyzable Analogues. Haraguchi, K.; Delaney, M. O.; Wiederholt, C. J.; Sambandam, A.; Hantosi, Z.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 3263.
A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks Via -Elimination of 2-Deoxyribonolactone. Bales, B. C.; Pitie, M.; Meunier, B.; Greenberg, M. M. J. Am. Chem. Soc. 2002, 124, 9062.
The 2-Deoxyribonolactone Lesion Produced in DNA by Neocarzinostatin and Other Damaging Agents Forms Cross-Links with the Base-Excision Repair Enzyme Endonuclease III. Hashimoto, M.; Greenberg, M. M.; Kow, Y. W.; Hwang, J.-T.; Cunningham, R. P. J. Am. Chem. Soc. 2001, 123, 3161.
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