Manisha Aggarwal, Ph.D., M.S.E.

  • Associate Professor of Radiology and Radiological Science

Research Interests

Diffusion MRI; High-field MRI Acquisition Techniques; Pre-clinical MRI; Susceptibility Imaging; Neuroimaging; Brain Atlases; Neurodegenerative Diseases; Oscillating Gradient Diffusion MRI more


Manisha Aggarwal, Ph.D., is an Associate Professor in the Department of Radiology and Radiological Science at the Johns Hopkins University School of Medicine.

Dr. Aggarwal is an investigator whose research focuses on high-field magnetic resonance imaging (MRI) techniques, advanced diffusion micro-imaging and acquisition methods, pre-clinical MRI, and the applications of these techniques for brain imaging. 

Dr. Aggarwal earned Ph.D. and M.S.E. degrees in biomedical engineering from the Johns Hopkins University School of Medicine. She holds a Bachelor of Technology (Honors) degree in instrumentation engineering and a minor in electronics and electrical communication engineering from the Indian Institute of Technology, Kharagpur. She completed her post-doctoral research in Radiology at Johns Hopkins University. 

Dr. Aggarwal is a Siebel Scholar and a Junior Fellow of the International Society for Magnetic Resonance in Medicine. more


  • Associate Professor of Radiology and Radiological Science

Departments / Divisions



  • B.Tech.; Indian Institute of Technology (Kharagpur) (India) (2004)
  • M.S.E.; Johns Hopkins University (Maryland) (2006)
  • Ph.D.; Johns Hopkins University School of Medicine (Maryland) (2012)

Research & Publications

Research Summary

Dr. Aggarwal's research focuses on advanced magnetic resonance imaging (MRI) techniques and their applications to mapping of brain tissue microstructure in the human brain and in pre-clinical models. Her primary research areas include:

1. High-field diffusion micro-imaging techniques and pulse sequences

2. Characterization of brain tissue microstructure using diffusion and susceptibility MR methods

3. Oscillating gradient diffusion MRI and its applications to animal models of neurological disorders

4. High-resolution neuroimaging and development of computational brain atlases


Selected Publications

View all on PubMed

Aggarwal M., Smith MD, Calabresi PA. Diffusion-time dependence of diffusional kurtosis in the mouse brain. Magn Reson Med. 2020;84(3):1564-1578

Aggarwal M., Kageyama Y., Li X., van Zijl P. B0-orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T. Magn Reson Med. 2016 Jun;75(6):2455-66

Aggarwal M., Nauen DW., Troncoso JC., Mori S. Probing region-specific microstructure of human cortical areas using high angular and spatial resolution diffusion MRI. Neuroimage. 2015 Jan 15;105:198-207.

Aggarwal M., Zhang J., Pletnikova O., Crain B., Troncoso J., Mori S. Feasibility of creating a high-resolution 3D diffusion tensor imaging based atlas of the human brainstem: a case study at 11.7 T. Neuroimage. 2013 Jul 1;74:117-27.

Aggarwal M., Jones MV., Calabresi PA., Mori S., Zhang J. Probing mouse brain microstructure using oscillating gradient diffusion MRI. Magn Reson Med. 2012 Jan 67(1):98-109.

Contact for Research Inquiries

720 Rutland Avenue
217 Traylor Building
Baltimore, MD 21205 map

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Activities & Honors


  • Outstanding Junior Faculty Research Award, Johns Hopkins Radiology, 2019
  • Junior Fellow, International Society for Magnetic Resonance in Medicine (ISMRM), 2013
  • Siebel Scholar, 2012
  • Phi Beta Kappa, 2012
  • Finalist, ISMRM I. I. Rabi Young Investigator Award, 2010


  • International Society for Magnetic Resonance in Medicine
  • Organization for Human Brain Mapping
  • Society for Neuroscience

Professional Activities

  • Associate Editor - Frontiers in Oncology, 2020-
  • Program Committee Member, MICCAI Workshop on Computational Diffusion MRI, 2018 - 2020
  • Member, ISMRM Trainee Advisory Working Group, 2013 - 2014

Videos & Media

Lectures and Presentations

  • Pre-clinical and postmortem diffusion imaging
    Educational course - Organization for Human Brain Mapping (OHBM) Annual Meeting (06/14/2015)
  • How small is small? Probing very small compartment size - short diffusion time
    Educational course, ISMRM Annual Meeting (06/17/2018)
  • Application of diffusion MRI in animal models
    Educational course, ISMRM Annual Meeting (04/22/2017)
  • Diffusion microimaging and brain tissue microstructure
    Invited lecture - ICMRM Annual Meeting (08/04/2021)
  • Mesoscale imaging to micro-imaging and beyond: probing length scales in the brain with diffusion MRI
    Lecture - Oxford University Autumn School in Neuroscience (09/29/2020)
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