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Maged Mohamed Harraz, M.B.B.Ch., M.Sc., Ph.D.

Headshot of Maged Mohamed Harraz
  • Instructor of Neuroscience

Background

Dr. Harraz is an instructor in The Solomon H. Snyder Department of Neuroscience at Johns Hopkins University School of Medicine.

He studies the molecular mechanisms underlying motivation, reward, and cell survival/death. The long-term goal of his work is to leverage our understanding of these signaling pathways to identify therapeutic targets for neuropsychiatric and neurodegenerative disorders.

Dr. Harraz received his medical degree from the Suez Canal University School of Medicine in Ismailia, Egypt. He completed his Ph.D. in cell biology and molecular medicine at the University of Iowa Carver College of Medicine in Iowa City, IA, then conducted his postdoctoral work in neuroscience at Johns Hopkins University School of Medicine.

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Titles

  • Instructor of Neuroscience

Departments / Divisions

Education

Degrees

  • M.B.B.Ch.; Suez Canal University (Egypt) (1992)
  • M.Sc.; Suez Canal University (Egypt) (1998)
  • Ph.D.; University of Iowa (Iowa) (2006)

Research & Publications

Selected Publications

View all on PubMed

Harraz MM, Guha P, Malla A, Kang J, Semenza E, Cortés P, Snyder SH. The locomotor stimulating effect of cocaine is mediated by autophagic degradation of the dopamine transporter. In Review.

Harraz MM, Tyagi R, Cortés P, Snyder SH. Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation. Mol Psychiatry. 2016;21(3):313-9.

Guha P*, Harraz MM*, Snyder SH. Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proc Natl Acad Sci U S A. 2016;2;113(5):1417-22.*Equal contribution.

Harraz MM, Eacker SM, Wang X, Dawson TM, Dawson VL. MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci U S A 2012;109(46):18962-18967.

Harraz MM, Marden JJ, Zhou W, Zhang Y, Williams A, Sharov VS, Nelson K, Luo M, Paulson H, Schöneich C, Engelhardt JF. SOD1 mutations disrupt Redox-sensitive Rac Regulation of NADPH Oxidase in a Familial ALS Model. J Clin Invest 2008;118:659-670.

Patents

Method of identifying compounds useful to treat neuronal degenerative diseases
Patent # 2007/079141 A3 | 

Treatment of Depression by Targeting GAPDH”.
Patent # Provisional patent application No: 62/194,343 | 

Apparatus and methods for photoacoustic monitoring based on ultrasound neuromodulation
Patent # Provisional patent application No: 62/771,410 | 

Activities & Honors

Honors

  • NARSAD Young Investigator Award, Brain & Behavior Foundation, 2017
  • Johns Hopkins Discovery Award, Johns Hopkins University, 2019
  • Johns Hopkins Discovery Award, Johns Hopkins University, 2018
  • Johns Hopkins Discovery Award, Johns Hopkins University, 2017
  • Egypt National Academy of Sciences State Encouragement Award in Medical Sciences, Egypt National Academy of Sciences, 2010
  • Postdoctoral Fellowship, Maryland Stem Cell Research Fund, 2008
  • Tung-Yang Wing Award for Superior Achievement in Anatomy and Cell Biology Graduate Education, Department of Anatomy & Cell Biology, University of Iowa, Iowa City, IA, 2002
  • Predoctoral Fellowship, Egypt Ministry of Higher Education, 2000

Memberships

  • Society for Neuroscience
  • Society of Biological Psychiatry

Professional Activities

  • Review Editor, Frontiers in Neuroscience, section Neuroenergetics, Nutrition and Brain Health
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