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Lysandra Voltaggio, M.D.

Lysandra Voltaggio, M.D.

Headshot of Lysandra Voltaggio
  • Associate Professor of Pathology

Languages: English, Spanish


Anatomic Pathology, Cytopathology, Pathology

Research Interests

Cardiovascular diseases, particularly ischemia-reperfusion injury more


The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-3580

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-3580


Dr. Voltaggio is an associate professor in the Division Gastrointestinal and Liver Pathology since March 1st, 2014 and serves as the clinical director of Gastrointestinal Pathology. Dr. Voltaggio has made significant contributions to the fields of gastrointestinal pathology and these major accomplishments have led to her regional, national, and international reputation as a leader in this field.

Dr. Voltaggio has authored multiple peer-reviewed original clinical research articles, invited review articles, and four textbooks. Though her clinical research career has been focused on gastrointestinal pathology she is specially interested in inflammatory disorders of the digestive tract. She has identified novel histologic patterns of inflammation associated with certain infections as well as novel HPV-driven anal glandular neoplasms. Dr. Voltaggio has also authored a number of invited reviews, reflecting the national recognition of her expertise in this area.

The Johns Hopkins Gastrointestinal and Liver Fellowship became ACGME-equivalent under her directorship. More than half of the graduating fellows have embraced successful academic careers at institutions across the nation. In addition, she directs the annual Johns Hopkins GI/Liver CME course, which attracts a wide variety of local, national, and international participants including practicing pathologists and trainees. Dr. Voltaggio is heavily involved in resident and fellow teaching and gives a number of yearly, well-attended noon lectures to the pathology residents encompassing aspects of luminal gastrointestinal pathology.

Dr. Voltaggio devotes over 50% of her time to clinical work and is recognized nationally for her clinical excellence in diagnostic gastrointestinal pathology.  She receives consults from around the world and is invited to speak nationally and internationally on diagnostic gastrointestinal pathology. She is well-respected among JHH clinicians for her diagnostic acumen, collegiality, and effective communication.

Lastly, as a member of an underrepresented minority group herself, Dr. Voltaggio is fiercely dedicated to promoting diversity in our field.  She is an active member of the Pathology Diversity Committee and has been a key member of our diversity initiative. She has been a leader and participant in visits to medical schools across the country enriched for underrepresented minorities.  A number of diverse students have rotated with us in the department as a result of these visits. more


  • Associate Professor of Pathology

Departments / Divisions

  • Pathology - Gastroenterology and Liver Pathology



  • MD; University of Puerto Rico School of Medicine (2003)


  • Pathology; Thomas Jefferson University (2007)


  • Cytopathology; The George Washington University School of Medicine (2008)
  • The George Washington University School of Medicine (2009)

Board Certifications

  • American Board of Pathology (Anatomic Pathology) (2007)
  • American Board of Pathology (Cytopathology) (2008)

Research & Publications

Selected Publications

View all on PubMed

Windon AL, Almazan E, Oliva-Hemker M, Hutchings D, Assarzadegan N, Salimian K, Montgomery EA, Voltaggio L. Lymphocytic and Collagenous Colitis in Children and Adolescents: Comprehensive Clinicopathologic Analysis with Long-Term Follow Up. Hum Pathol. 2020 Sep 26; S0046-8177(20)30183-0. doi: 10.1016/j.humpath.2020.09.011

Zhang Y, Byrnes K, Lam-Himlin D, Pittman M, Pezhouh M, Gonzalez R, Alruwaii Z, Larman T, Miller J, Matoso A, Oshima K, Epstein JI, Montgomery EA, Voltaggio L. Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases. Am J Surg Pathol. 2020 Sep;44(9):1251-1258

Voltaggio L, McCluggage WG, Iding J, Brock M, Longacre T, Ronnett B. A Novel Group of HPV-Related Adenocarcinomas of the Lower Anogenital Tract (Vagina, Vulva, and Anorectum) in Women and Men Resembling HPV-related Endocervical Adenocarcinomas. Mod Pathol. 2020 May;33(5):944-952

Arnold CA, Montgomery EA, Voltaggio L. Syphilitic and Lymphogranuloma Venereum (LGV) Proctocolitis: Clues to a Frequently Missed Diagnosis. Am J Surg Pathol. 2013 Jan; 37(1):38-46

Voltaggio L, Murray R, Lasota J, Miettinen M. Gastric Shwannoma: A Clinicopathologic Study of 51 Cases and Review of the Literature. Hum Pathol. 2011. May;43 (5): 650-659

Activities & Honors


  • Golden Apple Teaching Award, Residents: George Washington University, 2013
  • 2015 Second most important publication between 2015-2016 on Lymphogranuloma venereum, International Union Against Sexually Transmitted Infections-Europe, 2015
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