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Lysandra Voltaggio, M.D.

Headshot of Lysandra Voltaggio
  • Associate Professor of Pathology

Languages: English, Spanish


Anatomic Pathology, Cytopathology, Pathology

Research Interests

Cardiovascular diseases, particularly ischemia-reperfusion injury more


The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-3580

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-3580


Dr. Voltaggio is an associate professor in the Division Gastrointestinal and Liver Pathology since March 1st, 2014 and serves as the Director of our Gastrointestinal and Liver Pathology Fellowship. Dr. Voltaggio has made significant contributions to the fields of gastrointestinal pathology and these major accomplishments have led to her regional, national, and international reputation as a leader in this field.

Dr. Voltaggio has authored multiple peer-reviewed original clinical research articles, invited review articles, and two textbooks. Though her clinical research career has been focused on gastrointestinal pathology she is specially interested in inflammatory disorders of the digestive tract. She has identified novel histologic patterns of inflammation associated with certain infections. Dr. Voltaggio has also authored a number of invited reviews on this subject, reflecting the national recognition of her expertise in this area.

Dr. Voltaggio directs the Hopkins Gastrointestinal and Liver Fellowship, which became ACGME-equivalent under her directorship. More than half of the graduating fellows have embraced successful academic careers at institutions across the nation. In addition, she directs the annual Johns Hopkins GI/Liver CME course, which attracts a wide variety of local, national, and international participants including practicing pathologists and trainees. Dr. Voltaggio is heavily involved in resident and fellow teaching and gives a number of yearly, well-attended noon lectures to the pathology residents encompassing aspects of luminal gastrointestinal pathology.

Dr. Voltaggio devotes approximately 50% of her time to clinical work and is recognized nationally for her clinical excellence in diagnostic gastrointestinal pathology.  She receives consults from around the world and is invited to speak nationally and internationally on diagnostic gastrointestinal pathology. She is well-respected among JHH clinicians for her diagnostic acumen, collegiality, and effective communication.

Lastly, as a member of an underrepresented minority group herself, Dr. Voltaggio is fiercely dedicated to promoting diversity in our field.  She is an active member of the Pathology Diversity Committee and has been a key member of our diversity initiative. She has been a leader and participant in visits to medical schools across the country enriched for underrepresented minorities.  A number of diverse students have rotated with us in the department as a result of these visits. more


  • Associate Professor of Pathology

Departments / Divisions



  • MD; University of Puerto Rico School of Medicine (2003)


  • Pathology; Thomas Jefferson University (2007)


  • Cytopathology; The George Washington University School of Medicine (2008)
  • The George Washington University School of Medicine (2009)

Board Certifications

  • American Board of Pathology (Anatomic Pathology) (2007)
  • American Board of Pathology (Cytopathology) (2008)

Research & Publications

Selected Publications

Hutchings D, Miller JA, Voltaggio L. Paradoxical gastrointestinal reactions in patients taking tumor necrosis factor inhibitors: a rare event that broadens the histologic spectrum of medication-associated injury. Hum Pathol. 2019 Mar;85:202-209. doi: 10.1016/j.humpath.2018.11.003. Epub 2018 Nov 16.

Pezhouh MK, Miller JA, Sharma R, Borzik D, Eze O, Waters K, Westerhoff MA, Parian AM, Lazarev MG, Voltaggio L. Refractory inflammatory bowel disease: is there a role for Epstein-Barr virus? A case-controlled study using highly sensitive Epstein-Barr virus-encoded small RNA1 in situ hybridization. Hum Pathol. 2018 Dec;82:187-192. doi: 10.1016/j.humpath.2018.08.001. Epub 2018 Aug 16.

Arnold C, Roth R, Arsenescu R, Harzman A, Lam-Himlin D, Berkeley L, Montgomery E, Voltaggio L. Sexually Transmitted Infectious Colitis vs. Inflammatory Bowel Disease: Distinguishing Features from a Case Controlled Study. Am J Clin Pathol. 2015. Nov; 144(5):771-81.

Arnold CA, Frankel WL, Guo L, Krishnan C, Pfeil S, Schumacher M, Voltaggio L, Yearsley MM, Chen W. Crystal-storing Histiocytosis in the Stomach: A Clue to Subtle Hematolymphoid Malignancies. Am J Surg Pathol. 2018 Oct;42(10):1317-1324. doi: 10.1097/PAS.0000000000001097.

Arnold CA, Montgomery EA, Voltaggio L. Syphilitic and Lymphogranuloma Venereum (LGV) Proctocolitis: Clues to a Frequently Missed Diagnosis. Am J Surg Pathol. 2013 Jan; 37(1):38-46.

Activities & Honors


  • Golden Apple Teaching Award, Residents: George Washington University, 2013
  • 2015 Second most important publication between 2015-2016 on Lymphogranuloma venereum, International Union Against Sexually Transmitted Infections-Europe, 2015

Patient Ratings & Comments

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