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Lyle Wilfred Ostrow, M.D., Ph.D.

Lyle Wilfred Ostrow, M.D., Ph.D.

Headshot of Lyle Wilfred Ostrow
  • Assistant Professor of Neurology


Amyotrophic Lateral Sclerosis (ALS), Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD), Muscular Dystrophies, Myasthenia Gravis, Myopathy, Neurology, Neuromuscular Pathology, Peripheral Neuropathies more

Research Interests

The role of astrocytes in ALS

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The Johns Hopkins Hospital

Appointment Phone: 410-502-6165
600 N. Wolfe Street
The John G. Rangos Sr. Building Suite 248
Baltimore, MD 21287 map
Phone: 410-502-6165 | Fax: 410-502-5459


Dr. Ostrow is an Assistant Professor of Neurology and Pathology at Johns Hopkins.  He received his M.D. and a Ph.D. in Biophysics from the State University of New York at Buffalo, followed by Medicine Internship, Neurology Residency and Neuromuscular Medicine Fellowship at Johns Hopkins.

Dr. Ostrow’s clinical practice and basic science research are focused on Amyotrophic Lateral Sclerosis (ALS), though he also sees patients with a broad range of nerve and muscle diseases. He performs outpatient diagnostic open muscle and nerve biopsies, reads clinical nerve and muscle pathology for the Johns Hopkins Neuromuscular Pathology Laboratory, attends on the Neurology Inpatient and Consult Services, and supervises the Neurology Residents’ and Neuromuscular Fellows’ Clinics.

He established and directs the Target ALS Multicenter Human Postmortem Tissue Core, a multicentered effort which integrates clinical and pathological data, tissue samples, biofluids, genomic data, and slide imaging – all made broadly available to the ALS research community to foster and accelerate collaborative ALS research among academia and industry researchers.  He is involved in numerous collaborative studies using these tools and has designed and continues to direct several ongoing multicentered research efforts, including a pre-competitive ALS biomarker development effort involving several research foundations and pharma/biotech companies. 

Dr. Ostrow serves on the Programmatic Panel for the Department of Defense (CDMRP) ALS Research Program, and on numerous committees and review panels for multiple ALS research foundations.  He is frequently invited to speak on postmortem tissue resources for research, biomarker development, and facilitating open and collaborative access to resources and data for neurodegenerative disease research. 

Complete list of published work (curated for accuracy): more


  • Assistant Professor of Neurology

Departments / Divisions

Centers & Institutes



  • MD PhD; SUNY at Buffalo School of Medicine (2005)


  • Neurology; Johns Hopkins University School of Medicine (2009)


  • Neuromuscular Medicine; Johns Hopkins University School of Medicine (2010)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2009)
  • United Council for Neurologic Subspecialties (Neuromuscular Medicine) (2017)

Additional Training

  • United Council for Neurologic Subspecialties (UCNS) / Clinical Neuromuscular Pathology

Research & Publications

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