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Lyle Wilfred Ostrow, M.D., Ph.D.

Lyle Wilfred Ostrow, M.D., Ph.D.

Headshot of Lyle Wilfred Ostrow
  • Assistant Professor of Neurology


Amyotrophic Lateral Sclerosis (ALS), Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD), Muscular Dystrophies, Myasthenia Gravis, Myopathy, Neurology, Neuromuscular Pathology, Peripheral Neuropathies more

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The Johns Hopkins Hospital

Appointment Phone: 410-502-6165
600 N. Wolfe Street
The John G. Rangos Sr. Building Suite 248
Baltimore, MD 21287 map
Phone: 410-502-6165 | Fax: 410-502-5459


Dr. Ostrow is an Assistant Professor of Neurology in the Neuromuscular Division at Johns Hopkins. He received his M.D. and a Ph.D. in Biophysics from the State University of New York at Buffalo, followed by Medicine Internship, Neurology Residency and Neuromuscular Medicine Fellowship at Johns Hopkins.

Dr. Ostrow’s clinical practice and basic science research are focused on Amyotrophic Lateral Sclerosis (ALS), though he also sees patients with a broad range of nerve and muscle diseases. He is Director of the JHU Neuromuscular Fellowship Program. He also performs open muscle and nerve biopsies and interprets and teaches nerve and muscle pathology as Assistant Director of the Neuromuscular Pathology Lab.

Dr. Ostrow is Chair of the Programmatic Panel for the Department of Defense ALS Research Program (ALSRP), presently the largest dedicated annual funder of ALS therapeutic discovery and early clinical validation. He led recent efforts to refine and develop new ALSRP funding mechanisms to help move novel pre-clinical therapeutics through the drug development pipeline, emphasize biomarker development, and foster open data and resource sharing.

He is Director of the JHU ALS Postmortem Tissue Core, a collaboration with the CDC National ALS Registry which integrates clinical, pathological, and genomic data with ALS patient tissue samples and slides - all made broadly available to academic and industry ALS researchers around the world. He serves on several ALS steering committees and review panels, and has given 30+ invited talks, grand rounds, and keynote lectures on ALS research, biomarker development, postmortem tissue banking, and harmonizing multicentered research efforts. 

Complete list of published work (curated for accuracy): more


  • Assistant Professor of Neurology

Departments / Divisions

Centers & Institutes



  • MD PhD; University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005)


  • Neurology; Johns Hopkins University School of Medicine (2009)


  • Neuromuscular Medicine; Johns Hopkins University School of Medicine (2010)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2009)
  • United Council for Neurologic Subspecialties (Neuromuscular Medicine) (2017)

Additional Training

  • United Council for Neurologic Subspecialties (UCNS) / Clinical Neuromuscular Pathology

Research & Publications

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