Lisa Elinor Kratz, Ph.D.

Headshot of Lisa Elinor Kratz
  • Associate Professor of Genetic Medicine

Research Interests

Inborn errors of metabolism; Disorders of cholesterol biosynthesis including Smith-Lemli-Opitz syndrome, sesmosterolosis, x-linked dominant Conradi Hünermann syndrome and CHILD sequence; Disorders of creatine synthesis and transport, Barth syndrome, and mevalonate kinase deficiency more


Dr. Lisa Kratz is an assistant professor of pediatrics at the Johns Hopkins University School of Medicine. Her research focuses on inborn errors of metabolism.  

She is also director of the Biochemical Genetics Laboratory at the Kennedy Krieger Institute.

Dr. Kratz received her undergraduate degree from Western Maryland College and her doctorate in human genetics from the University of Maryland at Baltimore. She completed a post-doctoral fellowship in biochemical genetics at the University of Colorado Health Sciences Center.

Prior to joining Johns Hopkins and the Kennedy Krieger Institute, Dr. Kratz was the assistant director of the biochemical diseases detection laboratory at Yale University.

Dr. Kratz is a member of the American Society of Human Genetics and the Society for Inherited Metabolic Disorders. more


  • Associate Professor of Genetic Medicine
  • Associate Professor of Pediatrics

Departments / Divisions

  • Genetic Medicine
  • Pediatrics - Kennedy Krieger Institute

Centers & Institutes



  • Ph.D.; University of Colorado Health Science Center (Colorado) (1991)

Additional Training


University of Maryland at Baltimore
Human Genetics
Baltimore, MD

Western Maryland College
Westminster, MD


University of Colorado Health Sciences Center
Biochemical Genetics


Biochemical Genetics, 1993


Research & Publications

Research Summary

Dr. Kratz's research focuses on inborn errors of metabolism. One particular area of interest involves disorders of cholesterol biosynthesis including Smith-Lemli-Opitz syndrome, desmosterolosis, x-linked dominant Conradi Hünermann syndrome, and CHILD sequence. She is also interested in disorders of creatine synthesis and transport, Barth syndrome and mevalonate kinase deficiency.

Selected Publications

Dias C, Rupps R, Millar B, Choi K, Marra M, Demos M, Kratz LE, Boerkoel CF. “Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders.” Orphanet J Rare Dis. 2014 Jun 25;9:94. doi: 10.1186/1750-1172-9-94.

Sparks SE, Wassif CA, Goodwin H, Conley SK, Lanham DC, Kratz LE, Hyland K, Gropman A, Tierney E, Porter FD. “Decreased cerebral spinal fluid neurotransmitter levels in Smith-Lemli-Opitz syndrome.” J Inherit Metab Dis. 2014 May;37(3):415-20. doi: 10.1007/s10545-013-9672-5. Epub 2014 Feb 6.

Gauthier N, Wu JW, Wang SP, Allard P, Mamer OA, Sweetman L, Moser AB, Kratz L, Alvarez F, Robitaille Y, Lépine F, Mitchell GA. “A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern.” PLoS One. 2013 Jul 5;8(7):e60581. doi: 10.1371/journal.pone.0060581. Print 2013.

Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. “Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.” Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.

Herman GE, Kratz L. “Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome.” Am J Med Genet C Semin Med Genet. 2012 Nov 15;160C(4):301-21. doi: 10.1002/ajmg.c.31340. Epub 2012 Oct 5.

Contact for Research Inquiries

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Activities & Honors


  • American Society of Human Genetics
  • Society for Inherited Metabolic Disorders
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