Lena Molly Mathews, M.D., M.H.S.

Headshot of Lena Molly Mathews
  • Medical Director, Cardiac Rehabilitation
  • Assistant Professor of Medicine

Languages: English, Kiswahili


Cardiology, Echocardiography

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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International Patients

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The Johns Hopkins Hospital

Appointment Phone: 443-997-0270
600 N. Wolfe Street
Baltimore, MD 21287
Phone: 410-955-5957 | Fax: 410-367-2151
The Johns Hopkins Hospital - Google Maps


Lena Mathews specializes in general cardiology and echocardiography. She received her medical degree from University of Pennsylvania School of Medicine and completed an internal medicine residency at Brigham and Women’s Hospital. She completed fellowships in cardiology and echocardiography at the Johns Hopkins University School of Medicine.

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  • Medical Director, Cardiac Rehabilitation
  • Assistant Professor of Medicine

Departments / Divisions



  • MD; University of Pennsylvania School of Medicine (2009)


  • Internal Medicine; Brigham and Women's Hospital (2012)


  • Cardiology; Johns Hopkins University School of Medicine (2017)
  • Johns Hopkins University School of Medicine (2018)

Board Certifications

  • American Board of Internal Medicine (Cardiovascular Disease) (2017)
  • National Board of Echocardiography (Echocardiography: National Board of Echocardiography) (2018)

Research & Publications

Selected Publications

Mathews L, Ding N, Sang Y, Loehr LR, Shin JI, Punjabi NM, Bertoni AG, Crews DC, Rosamond WD, Coresh J, Ndumele CE, Matsushita K, Chang PP. Racial Differences in Trends and Prognosis of Guideline-Directed Medical Therapy for Heart Failure with Reduced Ejection Fraction: the Atherosclerosis Risk in Communities (ARIC) Surveillance Study. J Racial Ethn Health Disparities. 2022 Jan 10. doi: 10.1007/s40615-021-01202-5. Online ahead of print. PMID: 35001343

Mathews L, Brewer LC. A Review of Disparities in Cardiac Rehabilitation: EVIDENCE, DRIVERS, AND SOLUTIONS. J Cardiopulm Rehabil Prev. 2021 Nov 1;41(6):375-382. doi: 10.1097/HCR.0000000000000659. PMID: 34727556 Review

Mathews L, Han D, Evans MK, Zonderman AB, Ndumele CE, Crews DC. Prevalence of Guideline-Directed Medical Therapy for Cardiovascular Disease Among Baltimore City Adults in the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Study. J Racial Ethn Health Disparities. 2021 Feb 16. doi: 10.1007/s40615-021-00984-y. Online ahead of print. PMID: 33594652

Mathews L, Ogunmoroti O, Nasir K, Blumenthal RS, Utuama OA, Rouseff M, Das S, Veledar E, Feldman T, Agatston A, Zhao D, Michos ED. Psychological Factors and Their Association with Ideal Cardiovascular Health Among Women and Men. J Womens Health (Larchmt). 2018 May;27(5):709-715. doi: 10.1089/jwh.2017.6563. Epub 2018 Jan 29. PMID: 29377738 Free PMC article.

Mathews L, Iantorno M, Schär M, Bonanno G, Gerstenblith G, Weiss RG, Hays AG. Coronary endothelial function is better in healthy premenopausal women than in healthy older postmenopausal women and men. PLoS One. 2017 Oct 26;12(10):e0186448. doi: 10.1371/journal.pone.0186448. eCollection 2017. PMID: 29073168 Free PMC article

Activities & Honors


  • American Heart Association


  • American College of Cardiology


Videos & Media

Lectures and Presentations

  • Endogenous Sex Hormone Levels And Endothelial Function Among Men and Post-Menopausal Women in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Poster Presentation, Mid Atlantic American College of Cardiology Conference (11/01/2017)
  • High Sensitivity Cardiac Troponin-T and Subsequent Risk of Hospitalization with Bleeding: The Atherosclerosis in Communities (ARIC) Study
    Oral Presentation, American Heart Association Scientific Sessions (11/01/2017)
  • Self-Perceived Psychological Factors and Their Impact on Ideal Cardiovascular Health by Gender: The Baptist Health South Florida (BHSF) Employee Study
    Poster Presentation, American Heart Association Epi/Lifestyles Session, Portland, Oregon (03/01/2017)
  • Healthy postmenopausal women have impaired coronary endothelial function measured on MRI after isometric handgrip exercise when compared to healthy premenopausal women
    Poster Presentation, Society of Clinical Magnetic Resonance Imaging Scientific Sessions, Washington, D.C. (02/01/2017)
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