Laurence Stephen Carroll, Ph.D.

  • Assistant Professor of Radiology and Radiological Science

Background

Dr. Carroll earned his bachelor of science in Chemistry and his Ph.D. in Organic Chemistry from University of Oxford, New College. Dr. Carroll’s career has been focused on a combination of organic synthesis and radiochemistry, for the development of new radiochemical methods and tracers for the imaging. He’s worked with multiple novel fluorine-18 radiotracers in the U.K. and U.S.A., from idea/structural development through to final GMP synthetic sequence.

His Ph.D. was specifically based around hypoxia, and the chemistry of the two main classes of imaging agent, leading to a number of publications. Concurrently, he began to work with biorthogonal chemistry, which continued into his work throughout his time at Imperial College being at the cutting edge of research into reactions such as the Inverse electron-demand Diels-Alder reaction.

He has been at Johns Hopkins University since 2018, where he is an Assistant Professor in Radiology, working within the PET Center and interacting with targets in Oncology and Infection.

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Titles

  • Assistant Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • Ph.D.; Oxford University (United Kingdom) (2009)

Research & Publications

Selected Publications

Braga M, Leow CH, Gil JH, Teh JH, Carroll L, Long NJ, Tang MX, Aboagye EO. Investigating CXCR4 expression of tumor cells and the vascular compartment: A multimodal approach. PLoS One. 2021;16 (11); e0260186

Allott L, Chen C, Braga M, Leung SFJ, Wang N, Barnes C, Brickute D, Carroll L, Aboagye EO. Detecting hypoxia in vitro using 18F-pretargted IEDDA “click” chemistry in live cells. RSC Adv. 2021;11(3);20335-20341

Ordonez AA, Abhishek S, Singh AK, Klunk MH, Azad BB, Aboagye EO, Carroll L, Jain SK. Caspase-Based PET for Evaluating Pro-Apoptotic Treatments in a Tuberculosis Mouse Model. Mol. Imaging Biol. 2020; doi: 10.1007/s11307-020-01494-9

Pivovano G, Ordonez AA, Jain SK, Reiner T, Carroll LS, Pillarsetty NVK. Rapid Detection of SARS-CoV-2 using a radiolabeled antibody. Nuc Med Biol. 2021;98-99;69-75

Adilbay D, Gonzales J, Zazhytska M, de Souza Franca PD, Roberts S, Viray T, Artschwager R, Patel S, Kodra A, Overdevest JB, Chow CY, King GF, Jain SK, Ordonez AA, Carroll LS, Reiner T, Pillarsetty N.  Non-invasive diagnostic method to objectively measure olfaction and diagnose smell disorders by molecularly targeted fluorescent imaging agent. bioRxiv. 2022 Nov 29:2021.10.07.463532. doi: 10.1101/2021.10.07.463532

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