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Lauren M. Osborne, M.D.

Lauren M Osborne, M.D.

Headshot of Lauren M. Osborne
  • Assistant Director, Johns Hopkins Women's Mood Disorders Center
  • Associate Professor of Psychiatry and Behavioral Sciences

Specializes in: Adults (18+ years)



Adult Psychiatry, Anxiety Disorders, Bipolar Disorder, Depression, Mood Disorders, Postpartum Depression, Pregnancy and Childbirth, Psychiatry, Psychiatry and Behavioral Sciences, Women's Reproductive Health more


Dr. Osborne graduated from Weill Cornell Medical College and received her training at Columbia University/New York State Psychiatric Institute. She completed both clinical and research fellowships in women's mental health, and is an expert on the diagnosis and treatment of mood and anxiety disorders during pregnancy, the postpartum, the premenstrual period, and perimenopause. She conducts research on the biological pathways that contribute to mental illness at times of reproductive life cycle transition, working particularly on the role of the immune system. She also provides advanced training in reproductive psychiatry and leads the Reproductive Psychiatry Fellowship training program. more


  • Assistant Director, Johns Hopkins Women's Mood Disorders Center
  • Associate Professor of Psychiatry and Behavioral Sciences
  • Associate Professor of Gynecology and Obstetrics

Departments / Divisions



  • MD; Medicine; Weill Cornell Medicine (2009)


  • Psychiatry; New York-Presbyterian/Columbia University Irving Medical Center (2013)


  • Psychiatry; New York-Presbyterian/Columbia University Irving Medical Center (2014)

Research & Publications

Clinical Trial Keywords

postpartum depression, antenatal anxiety, women's mental health

Clinical Trials

The women's mood disorders center is currently recruiting pregnant women with and without mood and anxiety disorders for an ongoing prospective study of the biological mechanisms of mood and anxiety disorders during pregnancy and the postpartum.

Selected Publications

Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study. Osborne LM, Gispen F, Sanyal A, Yenokyan G, Meilman S, Payne JL. Psychoneuroendocrinology. 2017 Feb 16;79:116-121. doi: 10.1016/j.psyneuen.2017.02.012. [Epub ahead of print]

Returning to tricyclic antidepressants for depression during childbearing: clinical and dosing challenges.  Osborne LM, Birndorf CA, Szkodny LE, Wisner KL. Arch Womens Ment Health. 2014 Jun;17(3):239-46. doi: 10.1007/s00737-014-0421-z. Epub 2014 Mar 26.

Perinatal depression--the fourth inflammatory morbidity of pregnancy?: Theory and literature review. Osborne LM, Monk C. Psychoneuroendocrinology. 2013 Oct;38(10):1929-52. doi: 10.1016/j.psyneuen.2013.03.019. Epub 2013 Apr 20.

Contact for Research Inquiries

Activities & Honors


  • American Psychiatric Association, 2011
  • American Women Psychiatrists, 2011
  • Society of Biological Psychiatry, 2015
  • Psychoneuroimmunology Research Society, 2014
  • International Marce Society, 2014

Videos & Media

Recent News Articles and Media Coverage

Post-Partum Depression: A Clinical, Not Legal, Issue, MedPage Today (02/07/2018)

Why Some Women May Be More Biologically Susceptible to Postpartum Depression, Shape (3/22/2017)

Research links postpartum depression with diminished levels of 'anti-anxiety' hormone, Johns Hopkins The HUB (3/20/2017)

Low Levels of ‘Anti-Anxiety’ Hormone Linked to Postpartum Depression, Johns Hopkins Medicine News Release (3/14/2017)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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