Research Summary
Dr. Osborne's lab investigates the role of the immune system and neurosteroids in maternal psychiatric illness. She conducts both translational research and intervention trials.
Clinical Trial Keywords
postpartum depression, antenatal anxiety, women's mental health
Clinical Trials
The Center for Women's Reproductive Mental Health is currently recruiting pregnant women with and without mood and anxiety disorders for ongoing prospective studies of the biological mechanisms of mood and anxiety disorders during pregnancy and the postpartum. We also have studies for women with premenstrual symptoms and polycystic ovary syndrome.
Selected Publications
Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study. Osborne LM, Gispen F, Sanyal A, Yenokyan G, Meilman S, Payne JL. Psychoneuroendocrinology. 2017 Feb 16;79:116-121. doi: 10.1016/j.psyneuen.2017.02.012. [Epub ahead of print]
Returning to tricyclic antidepressants for depression during childbearing: clinical and dosing challenges. Osborne LM, Birndorf CA, Szkodny LE, Wisner KL. Arch Womens Ment Health. 2014 Jun;17(3):239-46. doi: 10.1007/s00737-014-0421-z. Epub 2014 Mar 26.
Perinatal depression--the fourth inflammatory morbidity of pregnancy?: Theory and literature review. Osborne LM, Monk C. Psychoneuroendocrinology. 2013 Oct;38(10):1929-52. doi: 10.1016/j.psyneuen.2013.03.019. Epub 2013 Apr 20.
