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Sheng-Fu Larry Lo, M.D., M.H.S.

Headshot of Sheng-Fu Larry Lo
  • Director, Spinal Oncology
  • Assistant Professor of Neurosurgery

Specializes in: Adults (18+ years)


Languages: English, Japanese, Mandarin


Arteriovenous Malformations (AVM), Back Disorders, Back Injuries, Back Pain, Cavernous Malformations, Cervical Degenerative Disc Disease, Cervical Degenerative Disc Herniation, Cervical Spine Trauma, Cervical Spondylosis, Chondrosarcoma, Chordomas, Complex Spinal Reconstructions, Degenerative Disc Disease, Degenerative Spine Disease, Herniated Disc, Kyphosis, Neurological Surgery, Neurosurgery, Sacral Tumors, Sciatica, Scoliosis, Spinal Column Tumors, Spinal Ependymoma, Spinal Meningioma, Spinal Schwannoma, Spinal Stenosis, Spondylolisthesis more

Research Interests

Dr. Lo’s research focuses on understanding the biology and clinical outcomes of spinal tumors, and new surgical procedures and innovative technology to improve patient safety and spinal fusion. more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-4424
600 N. Wolfe Street
Meyer Building 5-109
Baltimore, MD 21287 map
Fax: 443-287-6423

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-4424
601 N. Caroline St.
Baltimore, MD 21287 map
Fax: 443-287-6423

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-955-4424
301 Mason F Lord Drive
Neurosurgery Suite 2100
Baltimore, MD 21224 map
Phone: 410-550-0465 | Fax: 443-287-6423


Dr. Lo is an Assistant Professor of Neurosurgery at Johns Hopkins University School of Medicine. He is also a member of Neurosurgical Spine Center and an attending physician at Johns Hopkins Hospital. He is board certified in neurosurgery by the American Board of Neurological Surgery.

Dr. Lo’s clinical interests include primary and metastatic tumors of the spinal column, sacral tumors, spinal cord tumors, disorders of spinal alignment and degenerative spine disease. His research focuses on understanding the biology and clinical outcomes of spinal tumors, and new surgical procedures and innovative technology to improve patient safety and spinal fusion. His research has received numerous awards including the Neurosurgery Chairman’s Award for Improving Patient Safety.

Dr. Lo received his undergraduate degree in Chemistry in 3 years from Macalester College. He then obtained his medical and master of health science degrees from Yale University School of Medicine, as well the prestigious Howard Hughes Medical Institute research fellowship. He completed an internship in General Surgery and residency in Neurological Surgery at The Johns Hopkins Hospital and was recognized with the Irving J. Sherman Award for Resident Achievement. Dr. Lo also completed fellowship surgical training in Complex Spine Surgery and Spinal Oncology under Dr. Ziya L. Gokaslan at The Johns Hopkins Hospital. Dr. Lo was an Assistant Professor of Neurological Surgery at Columbia University College of Physicians and Surgeons and attending physician at New York-Presbyterian/Columbia University Medical Center before returning to Johns Hopkins. more


  • Director, Spinal Oncology
  • Assistant Professor of Neurosurgery

Departments / Divisions



  • MD MHS; Yale School of Medicine (2009)


  • Neurological Surgery; Johns Hopkins University School of Medicine (2016)

Board Certifications

  • American Board of Neurological Surgery (Neurological Surgery) (2019)

Research & Publications

Selected Publications

View all on PubMed

Perdomo-Pantoja A, Ishida W, Zygourakis C, Holmes C, Iyer RR, Cottrill E, Theodore N, Witham TF, Lo SL. Accuracy of Current Techniques for Placement of Pedicle Screws in the Spine: A Comprehensive Systematic Review and Meta-Analysis of 51,161 Screws. World Neurosurgery. 2019 Mar 15. [In press]

Ishida W*, Casaos J*, Chandra A, D'sa A, Ramhmdani S, Perdomo-Pantoja A, Theodore N, Gokaslan ZL, Wolinsky JP, Bydon A, Sciubba DM, Witham TF, Lo SL. Diagnostic Value of Intraoperative Electrophysiological Neuromonitoring During Resection of Intradural Extramedullary Spinal Tumors: A Single-Center Retrospective Cohort and Meta-Analysis. Journal of Neurosurgery: Spine. 2019 Mar 1:1-11. [In press]

Redmond KJ, Lo SL. Embolize, Resect, Irradiate. International Journal of Radiation Oncology, Biology, Physics. 2019 Jan 1;103(1):16.

Liu J, Zheng M, Yang W, Lo SL, Huang J. Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study. Journal of Neuro-Oncology. 2018 Sep;139(3):609-616.

Bettegowda C, Yip S, Lo SL, Fisher CG, Boriani S, Rhines LD, Wang JY, Lazary A, Gambarotti M, Wang WL, Luzzati A, Dekutoski MB, Bilsky MH, Chou D, Fehlings MG, McCarthy EF, Quraishi NA, Reynolds JJ, Sciubba DM, Williams RP, Wolinsky JP, Zadnik PL, Zhang M, Germscheid NM, Kalampoki V, Varga PP, Gokaslan ZL; AOSpine Knowledge Forum Tumor. Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival. Neuro-Oncology. 2017 Mar 1;19(3):405-413.

Anderson L, Antkowiak P, Asefa A, Ballard A, Bansal T, Bello A, Berne B, Bowsher K, Blumenkopf B, Broverman I, Bydon M, Chao K, Como P, Cork K, Costello A, De Laurentis K, DeMarco A, Dean H, Doucet J, Dworak B, Epperson L, Franca E, Ghassemian N, Ghosh C, Govindarajan A, Gupta J, Gutowski S, Herrmann R, Hoffmann M, Heetderks W, Hsu S, Kaufman D, Keegan E, Kittlesen G, Khuu K, Lee H, Lo L, Marcus I, Marjenin T, Mathews B, Misra S, Pinto V, Ramos V, Raben S, Russell A, Saha D, Seog J, Shenouda C, Smith M, Tang X, Wachrathit K, Waterhouse J, Williams D, Zheng X, Pena C. FDA Regulation of Neurological and Physical Medicine Devices: Access to Safe and Effective Neurotechnologies for All Americans. Neuron. 2016; 92(5):943-948.

Lo SF, Ishida W, Allaf ME, Kalmar A, Lum YW, Wolinsky JP. Robot- Assisted Resection of a Presacral Schwannoma: A Technical Note. World Spinal Column Journal. 2016 May; 7(2):129-34.

Lo SF, Otake Y, Puvanesarajah V, Wang AS, Uneri A, De Silva T, Vogt S, Kleinszig G, Elder BD, Goodwin CR, Kosztowski TA, Liauw JA, Groves M, Bydon A, Sciubba DM, Witham TF, Wolinsky JP, Aygun N, Gokaslan ZL, Siewerdsen JH. Automatic Localization of Target Vertebrae in Spine Surgery: Clinical Evaluation of the LevelCheck Registration Algorithm. Spine (Phila Pa 1976). 2015 Apr 15;40(8):E476-83.

Lo SF*, Boriani S*, Puvanesarajah V, Fisher CG, Varga PP, Rhines LD, Germscheid NM, Luzzati A, Chou D, Reynolds JJ, Williams RP, Zadnik P, Groves M, Sciubba DM, Bettegowda C, Gokaslan ZL; AOSpine Knowledge Forum Tumor. Aneurysmal bone cysts of the spine: treatment options and considerations. Journal of Neuro-Oncology. 2014 Oct;120(1):171-8.

Activities & Honors


  • Irving J. Sherman Award for Resident Achievement, Johns Hopkins School of Medicine, 2015
  • Neurosurgery Chairman's Award for Improving Patient Safety, Johns Hopkins School of Medicine, 2015


  • Congress of Neurological Surgeons
  • American Association of Neurological Surgeons
  • American College of Surgeons
  • North American Spine Society
  • AANS/CNS Joint Section on Disorders of the Spine and Peripheral Nerves
  • AANS/CNS Joint Section on Tumors
  • NASS Section on Robotics and Navigation

Videos & Media

Play Video:

Thoracic Spinal Tumor | Brian’s Story

Lectures and Presentations

  • Anterior Approaches to the Craniocervical Junction
    Oral Presentation, Neurosurgery Grand Rounds, New York, NY (09/08/2016)
    Columbia University College of Physicians & Surgeons
  • Surgical Management of Metastatic Spine Disease
    Invited Lecture, Hematology/Oncology Seminar, New York, NY (02/15/2017)
    Columbia University College of Physicians and Surgeons
  • Timing of Operative Intervention in the Cervical Trauma Patient
    Invited Lecture, Annual Meeting, Boston, MA (10/07/2017)
    Congress of Neurological Surgeons
  • Surgical Management of the Patient with Tandem Spinal Stenosis
    Invited Lecture, Annual Meeting, Orlando, FL (10/25/2017)
    North American Spine Society
  • Humanized Mouse Models in Neuro-Oncology
    Oral Presentation, Neurosurgery Grand Rounds, Baltimore, MD (11/16/2017)
    Johns Hopkins School of Medicine
  • Surgeon’s Perspective: Intraoperative Neurophysiological Monitoring for Minimally Invasive Spine Procedures
    Invited Lecture, Annual Meeting, Orlando, FL (02/24/2018)
    American Society of Neurophysiological Monitoring
  • Investigation of In Vivo Synergistic Effect of Checkpoint Blockade and Radiation Therapy Against Chordomas in a Humanized Mouse Model
    Platform Presentation, International Chordoma Research Workshop, Boston, MA (03/22/2019)
    Chordoma Foundation
  • Surgical Management of Metastatic Spine Disease
    Invited Lecture, Clemenceau Medical Center 4th NeuroSpine Summit, Beirut, Lebanon (05/11/2018)
  • Sacral Fracture Management 101
    Invited Lecture, 4th Annual Seattle Spine Trauma Summit, Seattle, WA (05/18/2018)
  • Anterior Approaches to Craniocervical Junction
    Invited Lecture, Eighth Annual Johns Hopkins Spine Workshop, Baltimore, MD (09/07/2018)
  • Contemporary Management of Spinal Fractures
    Platform Presentation, 2019 AANS Annual Scientific Meeting, San Diego, CA (04/17/2019)
  • Ependymomas and Spinal Cord Tumors: Current Treatment Strategies and Limitations
    Invited Lecture, Tumor Treating Fields as the Novel Standard of Care for GBM: Fourth Modality on Cancer Therapy Clinical Training and Education, Bethesda, MD (05/09/2019)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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