Khaled Mahmoud El-Shami, M.B.Ch.B., Ph.D., M.S.

Headshot of Khaled Mahmoud El-Shami
  • Assistant Professor of Oncology

Languages: English, Arabic


Acute Leukemia, Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), Hematologic Malignancies, Leukemia, Lymphoma, Medical Oncology, Myelodysplastic Syndromes (MDS), Myelodysplastic/Myeloproliferative Neoplasms, Myeloma more

Research Interests

Drug Development in Myeloid Malignancies; Immunotherapy of Hematologic Cancers; Hematologic Malignancies; Acute Leukemias; Chronic Leukemias; Myelodysplastic Syndromes; Myeloprolifetive Neoplasms; Lymphomas more

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Outside of Maryland & Washington D.C.

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Sibley Memorial Hospital

Appointment Phone: 202-660-6500
5255 Loughboro Road NW
Johns Hopkins Kimmel Cancer Center
Washington, DC 20016
Phone: 202-660-6500 | Fax: 202-660-6501
Sibley Memorial Hospital - Google Maps

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center - Google Maps


Khaled M. El-Shami, M.B.Ch.B., Ph.D., is a medical oncologist at Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital, as well as an assistant professor of oncology in the Division of Hematologic Malignancies at Johns Hopkins University School of Medicine.

Listen to Dr. El-Shami's Cancer Matters podcast episode to learn more about his work.

Dr. El-Shami's clinical interests are in hematologic malignancies, including leukemias, lymphomas and myelomas, as well as gastrointestinal cancers and melanoma.

Dr. El-Shami graduated from Alexandria University Faculty of Medicine in Alexandria, Egypt, where he did a residency in the Department of Neurosurgery. He was a Chevening Scholar as a M.S. student in molecular genetics at the University of Sussex in the United Kingdom, as well as a Sam Cohen Windhoek Scholar as a Ph.D. student in cancer immunology at the Weizmann Institute in Israel. Dr. El-Shami also completed a residency in internal medicine at George Washington University School of Medicine, a fellowship in tumor immunology and biology at the National Cancer Institute, and a fellowship in medical oncology at Johns Hopkins University School of Medicine. Dr. El-Shami previously served as faculty at Georgetown University and George Washington University.

Dr. El-Shami has been named a Top Doctor by Washingtonian Magazine for several years.

Dr. El-Shami is a member of the American Association for Advancement of Science, the American Association of Cancer Research, the American Association of Immunologists, the American Society for Gene Therapy and the American Society of Clinical Oncology.

Dr. El-Shami's research focus is on hematologic malignancies, including acute and chronic leukemias, myelodysplastic syndromes, myeloprolifetive neplasms and lymphomas. He has received the National Institutes of Health Clinical Research Scholars Award, an American Medical Association Seed Grant and an American Society of Clinical Oncology Merit Award. more


  • Assistant Professor of Oncology

Departments / Divisions

Centers & Institutes



  • MBChB MS; Alexandria University Faculty of Medicine (1987)


  • Surgery; Alexandria University Hospital (1992)
  • Internal Medicine; The George Washington University School of Medicine (2005)


  • Oncology; Johns Hopkins University School of Medicine (2008)

Research & Publications

Selected Publications

View all on PubMed

Hossain, A., Rafei, H., Jariwala, A., El-Shami, K. "A rare breed: Wild-type braf and ighv expression in a 29 year old lady with classical hairy cell leukemia." Leuk Res Rep. 2017 Jan 24;7:20-22. doi: 10.1016/j.lrr.2017.01.001. eCollection 2017.

El-Shami, K., Oeffinger, K.C., Erb, N.L., Willis, A., Bretsch, J.K., Pratt-Chapman, M.L., Cannady, R.S., Wong, S.L., Rose, J., Barbour, A.L., Stein, K.D., Sharpe, K.B., Brooks, D.D., Cowens-Alvarado, R.L. "American Cancer Society Colorectal Cancer Survivorship Care Guidelines." CA Cancer J Clin. 2015 Nov-Dec;65(6):428-55. doi: 10.3322/caac.21286. Epub 2015 Sep 8. Review.

Zheng, L., Edil, B.H., Soares, K.C., El-Shami, K., Uram, J.N., Judkins, C., Zhang, Z., Onners, B., Laheru, D., Pardoll, D., Jaffee, E.M., Schulick, R.D. "A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer." Ann Surg Oncol. 2014 Nov;21(12):3931-7. doi: 10.1245/s10434-014-3844-x. Epub 2014 Jun 19.

Parikh, S.A., Kantarjian, H., Schimmer, A., Walsh, W., Asatiani, E., El-Shami, K., Winton, E., Verstovsek, S. "Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis." Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9. doi: 10.3816/CLML.2010.n.059.

El-Shami, K., Stone, R.M., Smith, B.D. "FLT3 inhibitors in acute myeloid leukemia." Expert Rev Hematol. 2008 Dec;1(2):153-60. doi: 10.1586/17474086.1.2.153. Review.

Activities & Honors


  • Top Doctor, Washingtonian Magazine
  • Merit Award, American Society of Clinical Oncology
  • Attending of the Year Award, George Washington University School of Medicine
  • Clinical Research Scholars Award, National Institutes of Health


  • American Association for Advancement of Science


  • American Association of Cancer Research


  • American Association of Immunologists


  • American Society for Gene Therapy


  • American Society of Clinical Oncology


Videos & Media

Recent News Articles and Media Coverage

Cancer Matters Podcast: Dr. Bill Nelson discussing the treatment of leukemia and the growing hematologic program at Sibley, Johns Hopkins Kimmel Cancer Center Podcasts (January 24, 2019)

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