Kenneth Jay Cohen, M.D., M.B.A.

Headshot of Kenneth Jay Cohen
  • Clinical Director Pediatric Oncology
  • Professor of Oncology


Pediatric Brain Cancer, Pediatric Brain Tumors, Pediatric Neuro-Oncology, Pediatric Oncology, Pediatric Spinal Cord Tumors more

Research Interests

Early-phase drug development for high-risk pediatric brain tumors more

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Main Phone

Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-8751
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, 11th Floor
Baltimore, MD 21287
Fax: 410-955-0028
The Johns Hopkins Hospital (Main Entrance) - Google Maps


Dr. Cohen is Director of Pediatric Neuro-Oncology and Clinical Director of the Division of Pediatric Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He received his undergraduate degree at Brown University and earned his MD at the Upstate Medical University, in Syracuse, NY. He did his general Pediatric Residency and Chief Residency at the University of Colorado and completed his Pediatric Hematology/Oncology Fellowship at Johns Hopkins. He has served on the faculty since 1994. His research centers on clinical trials of novel therapeutics for children with brain tumors.

Dr. Cohen is co-chair of the High-Grade Glioma committee for the Children's Oncology Group and in that capacity has a particular research interest in the development of therapeutics for the treatment of infiltrating gliomas.  He serves on the scientific advisory board for a number of organizations including St. Baldricks and the Childhood Brain Tumor Foundation.  He is on the editorial board for PDQ with responsibility for authorship of the pediatric CNS brain tumor summaries.

The Pediatric Neuro-Oncology program conducts a broad range of research centered primarily around the development and testing of novel therapeutics for children with brain tumors. The multidisciplinary nature of this work translates into continual collaboration with specialists in pediatric neurosurgery, radiation oncology, neuropathology, neuroradiology, neurology, neuro-ophthalmology, neuropsychology, and other related disciplines. more


  • Clinical Director Pediatric Oncology
  • Director, Pediatric Neuro-Oncology
  • Director, Strategic Planning, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Professor of Oncology
  • Professor of Pediatrics

Departments / Divisions

Centers & Institutes



  • MD; SUNY Upstate Medical University (1987)

Board Certifications

  • American Board of Pediatrics (Pediatric Hematology-Oncology) (1994)

Research & Publications

Research Summary

More children die of brain tumors than of any other type of pediatric cancer. Significant advances have been made in surgical and supportive care but with fewer evident therapeutic benefits. Dr. Cohen's clinical research focuses on the application of new therapeutics in children with high-risk brain tumors, with a particular focus on children with high-grade gliomas.

Clinical Trial Keywords

Pediatric brain tumors, Neuro-Oncology

Selected Publications

View all on PubMed

Dunkel IJ, Doz F, Foreman NK, Hargrave D, Lassaletta A, André N, Hansford JR, Hassall T, Eyrich M, Gururangan S, Bartels U, Gajjar A, Howell L, Warad D, Pacius M, Tam R, Wang Y, Zhu L, Cohen K. Nivolumab With or Without Ipilimumab in Pediatric Patients With High-Grade CNS Malignancies: Safety, Efficacy, Biomarker, and Pharmacokinetics: CheckMate 908. Neuro Oncol. 2023 Feb 20:

Cooney TM, Cohen KJ*, Guimaraes CV, Dhall G, Leach J, Massimino M, Erbetta A, Chiapparini L, Malbari F, Kramer K, Pollack IF, Baxter P, Laughlin S, Patay Z, Young Poussaint T, Warren KE. Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol. 2020 Jun;21(6):e330-e336

Naung H, Cohen KJ. An intrathecal limited postoperative chemotherapy regimen for the treatment of young children with nodular/desmoplastic medulloblastoma and medulloblastoma with extensive nodularity. J Neurooncol. 2021 May;152(3):567-572

Yeh JC, Huang P, Cohen KJ. Phase I and Phase II Objective Response Rates are Correlated in Pediatric Cancer Trials: An Argument for Better Clinical Trial Efficiency. J Pediatr Hematol Oncol. 2016 May 9.

Cohen KJ, Pollack IF, Zhou T, Buxton A, Holmes EJ, Burger PC, Brat DJ, Rosenblum MK, Hamilton RL, Lavey RS, Heideman RL. Temozolomide in the treatment of high-grade gliomas in children; a report from the Children’s Oncology Group.  Neuro Oncol. 2011 Mar;13(3):317-23

Activities & Honors


  • American Society of Clinical Oncology, 1994
  • American Society of Pediatric Hematology/Oncology, 1997
  • Society for Neuro-Oncology, 1999
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