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Juan C Troncoso, M.D.

Headshot of Juan C Troncoso
  • Director, Brain Resource Center
  • Professor of Pathology
Male

Languages: English, Spanish

Expertise

Pathology

Research Interests

Neuropathology of normal aging and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, fronto-temporal degeneration, Huntington's disease; Forensic neuropathology ...read more

Locations

The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-9790

Background

Dr. Juan Troncoso is a professor of pathology and neurology at the Johns Hopkins University School of Medicine. He is a board-certified neurologist and neuropathologist with expertise in the pathological diagnosis of dementias and the neuropathology of normal aging.

Dr. Troncoso serves as the director of the Brain Resource Center and leads the Neuropathology Core of the Alzheimer's Disease Research Center and Parkinson's disease Center at the Johns Hopkins University.

He earned his M.D. from the Pontificia Universidad Católica de Chile. He completed a residency in neurology at Hahnemann Medical College in Philadelphia followed by a Fellowship in neuropathology at the Johns Hopkins School of Medicine. He joined the Hopkins faculty in 1983.

Dr. Troncoso's research interests include the neuropathology of normal aging and its intersection with neurodegenerative diseases. The approach of Dr. Troncoso and his laboratory is to conduct morphological studies relevant to the pathobiology of aging and age-associated dementias and movement disorders, and concurrently to collaborate with studies of genetics, molecular biology, and proteomics of these disorders. Dr. Troncoso and his collaborators have been leaders in the application of unbiased stereology to the investigation of neurodegenerations and normal aging. The research activity of Dr. Troncoso is reflected in more than 350 peer-reviewed publications.

In the teaching domain, Dr. Troncoso has been director of the Johns Hopkins neuropathology Fellowship program for more than 20 years. In this capacity, he has supervised the training of many generations of neuropathologists.  He is a faculty member of the Aging and Dementia Training Program and of the Pathobiology Graduate Program at Johns Hopkins.

In parallel to his service and academic activities at Johns Hopkins, Dr. Troncoso has served as neuropathology consultant for the Office of the Chief Medical Examiner of Maryland since 1981. This experience in forensic neuropathology is the basis for his book Essential Forensic Neuropathology. (Lippincott, Williams & Wilkins 2009). 

...read more

Titles

  • Director, Brain Resource Center
  • Director, Neuropathology Core of the Alzheimer's Disease Research Center
  • Director, Neuropathology Fellowship training program
  • Professor of Pathology
  • Professor of Neurology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Faculty of Medicine Pontifica University Catolica de Chile (1973)

Residencies

  • Neurology; Hahnemann University Hospital (1978)
  • Pathology; Johns Hopkins University School of Medicine (1979)

Board Certifications

  • American Board of Pathology (Neuropathology) (1983)
  • American Board of Psychiatry And Neurology (Neurology) (1980)

Research & Publications

Research Summary

Dr. Troncoso’s research focuses on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders.

His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically engineered mouse models and in vitro systems.

Core Facility:

Selected Publications

View all on PubMed

West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 1994;344(8925):769-772

Rudow GL, O’Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso, JC. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathol. 2008;115 (4):461-70. PMCID: PMC2431149

Ling JP, Pletnikova O, Troncoso JC, Wong PC. NEURODEGENERATION. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science. 2015;349(6248):650-5. PMCID: PMC4825810

Pletnikova O, Kageyama Y, Rudow G, LaClair KD, Albert M, Crain BJ, Tian J, Fowler D, Troncoso JC. The spectrum of preclinical Alzheimer’s pathology and its modulation by ApoE genotype. Neurobiology of Aging. 2018 Nov; 71: 72-80

Nauen DW, Troncoso JC. Amyloid-beta is present in human lymph nodes and greatly enriched in those of the cervical region. Alzheimers Dement. 2021 May 31. doi: 10.1002/alz.12385. Online ahead of print. PMID: 34057798

Patents

Light Microscope Attachment for High Resolution Laser Labeling of Microscopic Glass Slides and Histological Sections
Patent # C12707 | 

Academic Affiliations & Courses

Graduate Program Affiliation

Faculty, Graduate Program, Pathobiology, The Johns Hopkins University School of Medicine

Activities & Honors

Memberships

  • American Association of Neuropathologists
  • Society for Neuroscience

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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