Joseph B. Margolick, M.D., Ph.D.

Headshot of Joseph B. Margolick
  • Joint Appointment in Medicine

Research Interests

Human immunodeficiency virus (HIV); HIV analysis; Immune assessment; Immune deficiency; T cells; Flow cytometry; Cell sorting; Pathogenesis of HIV more


Dr. Joseph B. Margolick holds a joint appointment in medicine at the Johns Hopkins University School of Medicine. He is a professor of molecular microbiology and immunology, of environmental health sciences and of epidemiology at the Johns Hopkins University Bloomberg School of Public Health. Dr. Margolick’s research focuses on the cellular immunology and pathogenesis of HIV infection.

He is currently engaged in studies that include ALIVE (AIDS Linked to the IntraVenous Experience) and SHIELD (The Study of HIV Infection in the Etiology of Lung Disease).

Dr. Margolick earned his M.D. and Ph.D. from the University of Southern California. He is trained in medicine, experimental pathology and immunology.

He is the director of the HPTN Network Laboratory’s Immunology Core and a co-director of the Becton Dickinson Immune Function Laboratory. He also serves on the Institutional Biosafety Committee. more


  • Joint Appointment in Medicine
  • Joint Appointment in Oncology

Departments / Divisions

Research & Publications

Core Facility:

  • HIV Analysis

Selected Publications

Lam JO, Bream JH, Sugar EA, Coles CL, Weber KM, Burk RD, Wiley DJ, Cranston RD, Reddy S, Margolick JB, Strickler HD, Wentz A, Jacobson L, Guo Y, Xiao W, Gillison ML, D'Souza G. “Association of serum cytokines with oral HPV clearance.” Cytokine. 2016 Jul;83:85-91. doi: 10.1016/j.cyto.2016.04.002. Epub 2016 Apr 8.

Kirkpatrick AR, Patel EU, Celum CL, Moore RD, Blankson JN, Mehta SH, Kirk GD, Margolick JB, Quinn TC, Eshleman SH, Laeyendecker O. “Development and evaluation of a modified fourth-generation human immunodeficiency virus enzyme immunoassay for cross-sectional incidence estimation in clade b populations.” AIDS Res Hum Retroviruses. 2016 May 5. [Epub ahead of print]

Zhang W, Nilles TL, Johnson JR, Margolick JB. “The effect of cellular isolation and cryopreservation on the expression of markers identifying subsets of regulatory T cells.” J Immunol Methods. 2016 Apr;431:31-7. doi: 10.1016/j.jim.2016.02.004. Epub 2016 Feb 19.

Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL. “Brief report: intestinal microbiota-produced trimethylamine-n-oxide and its association with coronary stenosis and HIV serostatus.” J Acquir Immune Defic Syndr. 2016 May 1;72(1):114-8. doi: 10.1097/QAI.0000000000000937.

Slama L, Jacobson LP, Li X, Palella FJ Jr, Margolick JB, Kingsley LA, Wiley DJ, Pialoux G, Dobs AS, Brown TT; Multicenter AIDS Cohort Study. “Longitudinal changes over 10 years in free testosterone among HIV-infected and HIV-uninfected men.” J Acquir Immune Defic Syndr. 2016 Jan 1;71(1):57-64. doi: 10.1097/QAI.0000000000000821.

Academic Affiliations & Courses

Courses and Syllabi

  • Critically Reviewing the Scientific Literature (260.615.01)
    Johns Hopkins Bloomberg School of Public Health
  • Immunology, Infection and Disease (260.631.01)
    Johns Hopkins Bloomberg School of Public Health
  • Biological Basis of Aging (260.665.01)
    Johns Hopkins Bloomberg School of Public Health
  • Major Global Infectious Diseases: Prospects for Control (260.606.13)
    Johns Hopkins Bloomberg School of Public Health
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