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Jonathan P. Ling, Ph.D.

Headshot of Jonathan P. Ling
  • Assistant Professor of Pathology

Background

Dr. Ling is an Assistant Professor of Pathology at The Johns Hopkins School of Medicine. His research combines bioinformatics and genetic engineering to develop therapeutic strategies for age-related neurodegenerative diseases and monogenic disorders. He employs large-scale computational analyses of next-generation sequencing data to identify novel disease mechanisms, with the goal of translating these discoveries to the clinic.

Dr. Ling received his undergraduate degree from Johns Hopkins University. He earned his Ph.D. from The Johns Hopkins School of Medicine and completed his postdoctoral fellowship at the JHU Kavli Neuroscience Discovery Institute. Dr. Ling joined the Johns Hopkins faculty in 2020.

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Titles

  • Assistant Professor of Pathology

Departments / Divisions

Education

Degrees

  • B.S.; Johns Hopkins University (Maryland) (2010)
  • Ph.D.; Johns Hopkins University School of Medicine (Maryland) (2017)

Research & Publications

Selected Publications

Ling JP, Pletnikova O, Troncoso JC, Wong PC. TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science. 2015 Aug 7;349(6248):650-5. PMCID: PMC4825810

Ling JP, Wilks C, Charles R, Leavey PJ, Ghosh D, Jiang L, Santiago CP, Pang B, Venkataraman A, Clark BS, Nellore A, Langmead B, Blackshaw S. ASCOT identifies key regulators of neuronal subtype-specific splicing. Nat Commun. 2020 Jan 9;11(1):137

Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC. PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons. Cell Rep. 2016 Sep 27;17(1):104–13. PMCID: PMC5082185

McClory SP, Lynch KW, Ling JP. HnRNP L represses cryptic exons. RNA. 2018 Jun;24(6):761-768. PMID: 29581412

*Jeong YH, *Ling JP, *Lin SZ, Donde AN, Braunstein KE, Majounie E, Traynor BJ, LaClair KD, Lloyd TE, Wong PC. Tdp-43 cryptic exons are highly variable between cell types. Mol Neurodegener. 2017 Feb 2;12(1):13. PMCID: PMC5289002. 

Activities & Honors

Honors

  • Kavli NDI Postdoctoral Fellowship, 2017
  • Mette Strand Award, Johns Hopkins University School of Medicine, 2016

Memberships

  • Society for Neuroscience
  • Association for Research in Vision and Ophthalmology
  • RNA Society
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