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Jack Ratchford, M.D.

John Nolan Ratchford, M.D.

Headshot of Jack Ratchford

Languages: English, Spanish


Multiple Sclerosis, Neurology, Optic Neuritis

Research Interests

Use of new imaging techniques in multiple sclerosis more


Johns Hopkins Medicine - Green Spring Station

10753 Falls Road
Pavilion II, Suite 115
Lutherville, MD 21093 map


Dr. Ratchford specializes in the care of patients with multiple sclerosis (MS) and spine disorders. His research focuses on the use of new imaging techniques in multiple sclerosis. One technology that is currently being studied at the center is use of an eye scanner that provides information about the health of the nerves in the retina. He also oversees several clinical trials for MS. 

Dr. Ratchford received his medical degree from Columbia University and a masters degree from Yale University. He completed his internship in internal medicine and residency in neurology at Columbia University. He then pursued a fellowship in Neuroimmunology at The Johns Hopkins Hospital. more

Departments / Divisions

Centers & Institutes



  • MD; Columbia University College of Physicians and Surgeons (2003)


  • Neurology; New York-Presbyterian/Columbia University Irving Medical Center (2007)


  • Neurology; Johns Hopkins University School of Medicine (2009)

Research & Publications

Clinical Trial Keywords

Daclizumab in multiple sclerosis; Estriol in multiple sclerosis

Selected Publications

View all on PubMed

Publications, Peer-Reviewed
1. Hiremath GS, Cettomai D, Baynes M, Ratchford JN, Kerr D, Greenberg BM, Calabresi PA. Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol
supplementation in multiple sclerosis. Multiple Sclerosis 2009;15:735-740.
2. Ratchford JN, Quigg ME, Conger A, Frohman T, Frohman EM, Balcer LJ, Calabresi PA, Kerr DA. Optical coherence tomography helps differentiate neuromyelitis optica
and MS optic neuropathies. Neurology 2009;73:302-8.
3. Burkholder BM, Osborne B, Loguidice M, Frohman TC, Conger A, Ratchford JN, Warner C, Markowitz CE, Jacobs DA, Galetta SL, Cutter GR, Maguire MG, Calabresi PA, Balcer LJ, Frohman EM. Macular volume determined by optical coherence
tomography as a measure of neuronal loss in multiple sclerosis. Arch Neurol 2009;66:1366-72.
4. Ratchford JN, Shore W, Hammond ER, Rose G, Rifkin R, Nie P, Tan K, Quigg ME, de Lateur BJ, Kerr DA. A pilot study of functional electrical stimulation cycling in
progressive multiple sclerosis. NeuroRehabilitation 2010;27:121-8.
5. Talman LS, Sackel DJ, Long DA, Bisker ER, Ratchford JN, Farrell SK, Loguidice MJ, Conger A, Frohman TC, Jacobs DA, Markowitz CE, Cutter GR, Ying G-S, Dai Y, Maguire MG, Galetta SL, Frohman EM, Calabresi PA, Balcer LJ. Longitudinal study of vision and retinal nerve fiber layer thickness in MS. Annals of Neurology 2010;67:749-60.
6. Syc SB, Warner CV, Hiremath GS, Farrell SK, Conger A, Frohman T, Ratchford JN, Cutter G, Balcer LJ, Frohman EM, Calabresi PA. Reproducibility of high-resolution
optical coherence tomography in multiple sclerosis. Multiple Sclerosis 2010;16:829-39.
7. Smith SA, Williams ZM, Ratchford JN, Newsome S, Farrell SK, Gifford A, Miller NR, van Zijl PCM, Calabresi PA, Reich DS. Diffusion tensor imaging of the optic nerve in
multiple sclerosis: association with retinal damage and visual disability. American Journal of Neuroradiology 2010;32:1662-8.
8. Cettomai D, Hiremath G, Ratchford J, Venkatesan A, Greenberg BM, McGready J, Pardo CA, Kerr DA, Frohman EM, Balcer LJ, McArthur JC, Calabresi PA. Associations
between retinal nerve fiber layer defects and optic nerve examination. Neurology 2010;75:1318-25.
9. Harrison DM, Caffo BS, Shiee N, Farrell JAD, Bazin P-L, Farrell SK, Ratchford JN, Calabresi PA, Reich DS. Longitudinal changes in diffusion tensor-based quantitative
MRI in multiple sclerosis. Neurology 2011;76;179-186.
10. Saidha S, Syc SB, Ibrahim MA, Eckstein C, Warner CV, Farrell SK, Oakley JD, Durbin MK, Meyer SA, Balcer LJ, Frohman EM, Rosenzweig JM, Newsome SD, Ratchford
JN, Nguyen QD, Calabresi PA. Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. Brain 2011;134:518-33.
11. Saidha S, Syc SB, Durbin MK, Eckstein C, Oakley JD, Meyer SA, Conger A, Frohman TC, Newsome S, Ratchford JN, Frohman EM, Calabresi PA. Visual dysfunction in
multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fibre layer
thickness. Multiple Sclerosis 2011;17:1449-63.
12. Syc SB, Saidha S, Newsome SD, Ratchford JN, Levy M, Ford E, Durbin MK, Oakley JD, Meyer SA, Frohman EM, Calabresi PA. Optical coherence tomography
segmentation reveals ganglion cell layer pathology after optic neuritis. Accepted to Brain 2011.
13. Ratchford JN, Endres CJ, Hammoud DA, Pomper MG, Shiee N, McGready J, Pham DL, Calabresi PA. Decreased microglial activation in MS patients treated with glatiramer
acetate. Accepted to Journal of Neurology 2011.
14. Blazek P, Davis SL, Burton E, Conger A, Conger D, Vernino S, Beh S, Stuve O, Greenberg B, Saidha S, Ratchford JN, Frohman TC, Calabresi PA, Balcer LJ, Frohman
EM. Pupillary reflex asymmetry ratios: objective characterization of the afferent pupillary defect in MS. Submitted 2011.

Publications, Non Peer-Reviewed
1. Ratchford JN. The immunology of multiple sclerosis. Neurology Report 2008;2:5-11.
2. Saidha S, Eckstein C, Ratchford JN. Optical coherence tomography as a marker of axonal damage in multiple sclerosis. CML-Multiple Sclerosis 2010;2:33-43.
3. Saidha S, Eckstein C, Ratchford JN. Optical coherence tomography for the detection of axonal damage in multiple sclerosis. CML-Ophthalmology 2010;20:77-88.
4. Saidha S, Eckstein, C, Ratchford JN. Optical coherence tomography as a marker of axonal damage in multiple sclerosis. Int J Clin Rev 2010;10:01.

1. Ratchford JN, Calabresi PA. The diagnosis of MS: white spots and red flags. Neurology 2008;70:1071-1072.

Activities & Honors


  • Inducted, Alpha Omega Alpha Medical Honor Society, 2003
  • Helen M. Sciarra Prize in Neurology, Columbia University College of Physicians and Surgeons, 2003
  • Named to Arnold P. Gold Foundation Humanism Honor Society which recognizes compassionate, humanistic clinicians, 2003
  • Awarded a Partners Multiple Sclerosis Clinical Fellowship Award, 2007


  • American Academy of Neurology

Videos & Media

Recent News Articles and Media Coverage

Side Effects of MS Treatments, WebMD (03/19/2014)

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