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Jochen Steppan, M.D.

Headshot of Jochen Steppan
  • Director of Perioperative Medicine, High Risk Cardiovascular Disease
  • Associate Professor of Anesthesiology and Critical Care Medicine
Male

Languages: English, French, German

Expertise

Adult Congenital Heart Disease, Anesthesiology, Cardiothoracic Anesthesiology, Pediatric Cardiac Anesthesiology, Pulmonary Hypertension ...read more

Locations

The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-7519

Background

Dr. Jochen Steppan's research focuses on the basic science aspects of vascular stiffness, an important predictor of aging-associated cardiovascular morbidity and pulmonary hypertension. 

In a collaborative effort with a  team of cardiovascular biologists, Dr. Steppan addresses important pathways of aging, associated changes in nitric oxide signaling, the nitroso-redox milieu, endothelial function, extracellular matrix composition and vascular reactivity. The goal of these studies is not merely to characterize and describe the underlying basic vascular pathophysiology, but to move those studies into the clinical realm to ultimately prevent, halt, or even reverse aging-associated vascular stiffness and pulmonary hypertension. 

This approach has been awarded with a SCA/IARS Mid-Career Award and an NIH K08 Award, to evaluate a novel  target: LOXL2 (lysine-oxidase-like-2), which may be intimately involved in the development or progression of pulmonary hypertension. This study will advance the understanding of LOXL2's role in the lung vasculature and may lead to the characterization of a novel therapeutic target, which is of critical importance for the treatment of this deadly disease. Furthermore, Dr. Steppan is a co-investigator of a R01, evaluating LOXL2 in aging-associated vascular stiffness. Lastly, he holds intramural awards to evaluate vascular stiffness in cerebral aneurysms and Vein of Galen Malformations.

...read more

Titles

  • Director of Perioperative Medicine, High Risk Cardiovascular Disease
  • Associate Professor of Anesthesiology and Critical Care Medicine

Departments / Divisions

Education

Degrees

  • MD; Ruprecht Karls Universitat Heidelberg (2007)

Residencies

  • Anesthesiology and Critical Care Medicine; Johns Hopkins University School of Medicine (2012)
  • Anesthesiology; University Hospital of Heidelberg (2008)

Fellowships

  • Anesthesiology and Critical Care Medicine; Johns Hopkins University School of Medicine (2013)

Board Certifications

  • American Board of Anesthesiology (Anesthesiology) (2013)

Additional Training

  • National Board of Echocardiography / Examination of Special Competence in Advanced Perioperative Transesophageal Echocardiography

Research & Publications

Research Summary

Dr. Steppan’s research focuses on the basic science aspects of vascular stiffness, an important predictor of aging associated cardio-vascular morbidity.

In a collaborative effort with a team of cardiovascular biologists, he addresses important pathways of aging associated changes in nitric oxide signaling, the nitroso-redox milieu, endothelial function, extracellular matrix composition and vascular reactivity. The goal of these studies is not merely to characterize and describe the underlying basic vascular pathophysiology but to move those studies into the clinical realm to ultimately prevent, halt or even reverse aging associated vascular stiffness.

This approach has recently been awarded with an NIH K08 award, to evaluate a novel target: LOXL2 (lysine-oxidase-like-2), which might be intimately involved in the development or progression of pulmonary hypertension. This study will advance the understanding of LOXL2's role in the lung vasculature, and might lead to the characterization of a novel therapeutic target, which is of critical importance for the treatment of this deadly disease.

Selected Publications

View all on PubMed

Steppan J, Jandu S, Savage W, Wang H, Kang S, Narayanan R, Nyhan D, Santhanam L. Restoring blood pressure in hypertensive mice fails to fully reverse vascular stiffness. Front Physiol. 2020 Jul 21;11:824

Steppan J, Wang H, Bergman Y, Rauer MJ, Tan S, Jandu S, Nandakumar K, Barreto-Ortiz S, Cole RN, Boronina TN, Zhu W, Halushka MK, An SS, Berkowitz DE, Santhanam L. Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening. Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H49-H59. doi: 10.1152/ajpheart.00670.2018. Epub 2019 Apr 19. PMID: 31002285

Cheema A, Ibekwe S, Nyhan D, Steppan J. When Your 35-Year-Old Patient has a Sternotomy Scar: Anesthesia for Adult Patients with Congenital Heart Disease Presenting for Noncardiac Surgery. Int Anesthesiol Clin. 2018 Fall;56(4):3-20. doi: 10.1097/AIA.0000000000000204. PMID: 30204603 Review. 

Obata Y, Barodka V, Berkowitz DE, Gottschalk A, Hogue CW, Steppan J. Relationship Between the Ambulatory Arterial Stiffness Index and the Lower Limit of Cerebral Autoregulation During Cardiac Surgery. J Am Heart Assoc. 2018 Feb 8;7(4):e007816. doi: 10.1161/JAHA.117.007816.

Steppan J, Diaz-Rodriguez N, Barodka VM, Nyhan D, Pullins E, Housten T, Damico RL, Mathai SC, Hassoun PM, Berkowitz DE, Maxwell BG, Kolb TM. Focused Review of Perioperative Care of Patients with Pulmonary Hypertension and Proposal of a Perioperative Pathway. Cureus. 2018 Jan 15;10(1):e2072. doi: 10.7759/cureus.2072

Patents

Arginase II: A Target Treatment of Aging Heart and Heart Failure
Patent # US 2009/0298912 A1 | 

Activities & Honors

Honors

  • Research Award for Cardiopulmonary Medicine-1, Johns Hopkins Annual Research Day, 2016
  • Research Award for Cardiothoracic Medicine, 17th Annual ACCM Research Day, 2015
  • Research Award, Johns Hopkins Annual Research Day, 2014
  • Research Award, Johns Hopkins Annual Research Day, 2011
  • Best Scientific Abstract, Maryland Society of Anesthesiologists, 2011
  • Best Abstracts of the Meeting: Anesthesiology Editor’s Picks, American Society of Anesthesiologists Annual Meeting, 2010
  • Best Scientific Abstract, Maryland Society of Anesthesiologists, 2010
  • Kosaka Award, International Anesthesia Research Society, 2009
  • German Acupuncture Award, best research study, 2006
  • PVRI Abstract Award, Pulmonary Vascular Research Institute, 2019
  • ACCM 2019 Research Day Poster Award for Basic Science-1, Annual ACCM Research Day, Johns Hopkins University, 2019
  • PVRI Best Basic Rapid Fire Award 2020, Pulmonary Vascular Research Institute, PVRI World Congress on PVD, 2020
  • Top Research Abstract, SCA's 2020 Annual Thoracic Anesthesia Symposium, 2020

Memberships

  • American Heart Association, 2004
  • American Society of Anesthesiologists, 2009
  • Deutsche Arztegesellschaft fur Akupunktur (German Medical Society for Acupuncture), 2006 - 2012
  • European Society of Anaesthesiology, 2014
    Diplomate
  • International Anesthesia Research Society, 2009
  • Society for Cardiovascular Anesthesiologists, 2012
  • Society for Pediatric Anesthesia, 2016
  • Congenital Cardiac Anesthesia Society, 2016
  • Pulmonary Vascular Research Institute, 2018
  • Association of University Anesthesiologists, 2018

Videos & Media

Recent News Articles and Media Coverage

Episode 59: Pulmonary Hypertension (audio recording, podcast, accrac.com), AACRaC: Anesthesia and Critical Care Reviews and Commentary, by Jed Wolpaw

Episode 130: Anesthesia for Adults with Congenital Heart Disease (audio recording, podcast, accrac.com), AACRaC: Anesthesia and Critical Care Reviews and Commentary, by Jed Wolpaw

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