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Child Abuse; Adverse Child Experiences; Psychiatric Assessment ...read more
My primary research focuses on two areas of investigation:
These two lines of research are interrelated and synergistic, with the study of maltreated individuals bringing several advantages to the RDoC project, including: the study of a subset of patients that are frequently treatment-resistant to standard clinical interventions; examination of a relatively homogenous sample with the onset of psychopathology proposed to be associated with stress-related mechanisms; and well-established relevant animal models to facilitate mechanistic translational research.
My investigations have utilized clinical assessment, neuroimaging, and genetic and epigenetic research methods, with the goal of understanding the effects of early adversity on later development and factors that modify outcomes. My work has embraced a broad spectrum of perspectives, from neurobiology to social policy
Wymbs NF, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Montalvo-Ortiz JL, Mostofsky S, Hudziak J, Kaufman J. Social supports moderate the effects of child adversity on neural correlates of threat processing. Child Abuse Negl. 2020 Feb 14;102:104413. doi: 10.1016/j.chiabu.2020.104413.PMID: 32065988 Kaufman, J.
Montalvo-Ortiz, J.L., Holbrook, H., O'Loughlin, K., Orr, C., Kearney, C., Yang, B.-Z., Wang, T., Zhao, H., Althoff, R., Garavan, H., Gelernter, J., Hudziak, H., 2018. Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth. Journal of Pediatrics, 202: 150-156. DOI: 10.1016/j.jpeds.2018.06.051; PMID: 30177354
Townsend, L, Kobak, K., Kearney, C., Milham, M., Andreotti, C., Escalera, J., Alexander, L., Gill, M.K., Birmaher, B., Sylvester, R., Rice, D., Deep, A., Kaufman, J. (2020). Development of Three Web-Based Computerized Versions of the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS-COMP) Child Psychiatric Diagnostic Interview: Preliminary Validity Data. Journal of the American Academy of Child and Adolescent Psychiatry, Feb;59(2):309-325. doi:10.1016/j.jaac. PMID: 31108163
Kaufman, J. (in press). A Child’s Right to Family, Lancet Psychiatry.
Montalvo-Ortiz, J.L, Bordner, K.A., Carlyle, B.C., Gelernter, J., Simen, A.A., Kaufman, J. (2016). The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Brain and Behavioural Research,15;315:71-4