Research Summary
Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to study brain function and various human diseases, such as brain tumor and stroke. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, tissue protein MR imaging, and high-resolution diffusion tensor imaging (DTI). A major part of his current research is in vivo imaging of experimental brain tumor models and clinical imaging of brain tumor patients using a new MRI technique, the amide proton transfer (APT) imaging. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and to improve the diagnostic capability of MRI and the patient outcome.
Selected Publications
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Jinyuan Zhou, Jean-Francois Payen, David A. Wilson, Richard J. Traystman, and P. C. M. van Zijl. Using the Amide Proton Signals of Intracellular Proteins and Peptides to Detect pH Effects in MRI. Nature Med. 9, 1085-1090 (2003)
Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Kun Yan, Silun Wang, De-Xue Fu, Jaishri Blakeley, Eric Ford, Betty Tyler, John Laterra, and Peter C.M. van Zijl. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med. 17, 130-134 (2011). PMC3058561
Jiang S, Eberhart CG, Lim M, Heo HY, Zhang Y, Blair L, Wen Z, Holdhoff M, Lin D, Huang P, Qin H, Quinones-Hinojosa A, Weingart JD, Barker PB, Pomper MG, Laterra J, van Zijl PCM, Blakeley JO, Zhou J. Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy. Clin. Cancer Res. 25, 552-561 (2019). PMC6335169
Zhou J, Heo HY, Knutsson L, van Zijl PCM, Jiang S. APT-weighted MRI: Techniques, current neuro applications, and challenging issues. J. Magn. Reson. Imaging. 50, 347-364 (2019). PMC6625919.
Zhou J, Zaiss M, Knutsson L, Sun PZ, Ahn SS, Aime S, Bachert P, Blakeley JO, Cai K, Chappell MA, Chen M, Gochberg DF, Goerke S, Heo HY, Jiang S, Jin T, Kim SG, Laterra J, Paech D, Pagel MD, Park JE, Reddy R, Sakata A, Sartoretti-Schefer S, Sherry AD, Smith SA, Stanisz GJ, Sundgren PC, Togao O, Vandsburger M, Wen Z, Wu Y, Zhang Y, Zhu W, Zu Z, van Zijl PCM. Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magn. Reson. Med. 88, 546-574 (2022). PMC9321891.
