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Jinyuan Zhou, Ph.D.

Headshot of Jinyuan Zhou
  • Professor of Radiology and Radiological Science

Research Interests

Chemical exchange saturation transfer (CEST) MRI; Amide proton transfer (APT) MRI; Brain tumor imaging; Stroke pH imaging; New MR imaging techniques; Molecular MR imaging more


Dr. Jinyuan Zhou is a Full Professor in the Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine. Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) to study brain function and diseases.

Dr. Zhou earned his Ph.D. in physics from the National Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics, Chinese Academy of Sciences. He performed a fellowship on in vivo MRI at the Johns Hopkins University School of Medicine. Dr. Zhou joined the Johns Hopkins faculty in 1999.

Dr. Zhou received the Outstanding Presidential Scholarship of the Chinese Academy of Sciences (1996). He has been recognized with the Distinguished Investigator Award of the Academy of Radiology Research. more


  • Professor of Radiology and Radiological Science

Departments / Divisions



  • Ph.D.; Chinese Academy of Sciences (China) (1996)

Additional Training

  • In Vivo MRI, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 1999, Fellowship

Research & Publications

Research Summary

Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to study brain function and various human diseases, such as brain tumor and stroke. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, tissue protein MR imaging, and high-resolution diffusion tensor imaging (DTI). A major part of his current research is in vivo imaging of experimental brain tumor models and clinical imaging of brain tumor patients using a new MRI technique, the amide proton transfer (APT) imaging. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and to improve the diagnostic capability of MRI and the patient outcome.

Selected Publications

View all on PubMed

Jinyuan Zhou, Jean-Francois Payen, David A. Wilson, Richard J. Traystman, and P. C. M. van Zijl. Using the Amide Proton Signals of Intracellular Proteins and Peptides to Detect pH Effects in MRI. Nature Med. 9, 1085-1090 (2003)

Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Kun Yan, Silun Wang, De-Xue Fu, Jaishri Blakeley, Eric Ford, Betty Tyler, John Laterra, and Peter C.M. van Zijl. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med. 17, 130-134 (2011). PMC3058561

Jinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A. Messina, Charles Eberhart, Martin Pomper, John Laterra, Peter B. Barker, Peter C.M. van Zijl, and Jaishri Blakeley. Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison with Gadolinium Enhancement. J. Magn. Reson. Imaging. 38, 1119-1128 (2013). PMC3664658

Jiang S, Eberhart CG, Lim M, Heo HY, Zhang Y, Blair L, Wen Z, Holdhoff M, Lin D, Huang P, Qin H, Quinones-Hinojosa A, Weingart JD, Barker PB, Pomper MG, Laterra J, van Zijl PCM, Blakeley JO, Zhou J. Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy. Clin. Cancer Res. 25, 552-561 (2019). PMC6335169

Zhou J, Heo HY, Knutsson L, van Zijl PCM, Jiang S. APT-weighted MRI: Techniques, current neuro applications, and challenging issues. J. Magn. Reson. Imaging. doi: 10.1002/jmri.26645 (2019). PMC6625919

Activities & Honors


  • Second-Class Young Scientist Award, Tianjuan Wang Foundation, the Chinese Physical Society, 1994
  • Second-Class Graduate Scholarship, Wuhan Institute of Physics, 1995
  • First-Class Graduate Scholarship, Wuhan Institute of Physics, 1996
  • First-Class Hong Kong Yilida Scholarship, The Chinese Academy of Sciences, 1996
  • Outstanding Presidential Scholarship, The Chinese Academy of Sciences, 1996
  • Second-Class Natural Science Prize, The Chinese Academy of Sciences, 1997
  • Award for Scientific Excellence, Division of MR Research, Department of Radiology, Johns Hopkins University, 2003 - 2016
  • Distinguished Investigator Award, The Academy of Radiology Research, 2012
  • January 2016 Issue Editor’s Picks, Magn. Reson. Med., 2016
  • 2nd Place Abstract Award in MR in Drug Development Study Group, 25th ISMRM Ann. Meeting, 2017
  • 1st Place Abstract Award in 2017 Radiology Research Day, Department of Radiology, JHU, 2017
  • The most cited papers in 2016 J. Magn. Reson. Imaging, 27th ISMRM Ann. Meeting, 2018


  • International Society of Magnetic Resonance in Medicine (ISMRM), 1998
  • International Society for Cerebral Blood Flow and Metabolism, 2002
  • American Association for Cancer Research (AACR), 2006
  • Radiological Society of North America (RSNA), 2011
  • National Neurotrauma Society (NNS), 2019
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