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Jianhua Xiong, Ph.D.

Headshot of Jianhua Xiong
  • Assistant Professor of Medicine

Research Interests

Cytokine and metabolic regulation of cell fate and function; Intercellular interactions; Protein-protein interactions; Vascular-immune crosstalk ...read more

Background

Dr. Xiong is an assistant professor of medicine in the Division of Endocrinology, Diabetes and Metabolism at the Johns Hopkins University School of Medicine. His research focuses on the cytokine and metabolic regulation of cell fate and function, ranging from basic molecular mechanisms to human disease. His research aims to understand the mechanisms of how cytokine signaling and vascular-immune crosstalk contribute to physiology and pathophysiology, and to facilitate the development of new therapies for metabolic, cardiovascular and inflammatory diseases as well as cancer. Dr. Xiong’s laboratory uses systems cell biology and immunology approaches to identify novel molecular and cellular targets that can be harnessed for cell therapy, immunotherapy, and drug discovery. 

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Titles

  • Assistant Professor of Medicine

Departments / Divisions

Education

Degrees

  • B.S.; China Agricultural University (China) (2007)
  • Ph.D.; Peking University (China) (2012)

Additional Training

  • University of California San Diego, California, 2014, Postdoctoral training, Biological Sciences
  • National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH), Maryland, 2021, Postdoctoral training, Molecular Medicine and Immunology

Research & Publications

Research Summary

Dr. Xiong's laboratory studies the cytokine and metabolic regulation of cell fate and function, ranging from basic molecular mechanisms to human disease. Dr. Xiong's research aims to understand the mechanisms of how cytokine signaling and vascular-immune crosstalk contribute to physiology and pathophysiology, and to facilitate the development of new therapies for metabolic, cardiovascular and inflammatory diseases as well as cancer. Dr. Xiong’s laboratory uses systems cell biology and immunology approaches to identify novel molecular and cellular targets that can be harnessed for cell therapy, immunotherapy and drug discovery.

Selected Publications

Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira, II, Brittain EL, Wolfgang MJ, Jurczk MJ, Fessel JP, Finkel T. A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Molecular Cell. 69(4):689–98 e7 (2018). (Editorially highlighted in Nature Reviews Molecular Cell Biology, Trends in Molecular Medicine and Trends in Endocrinology and Metabolism).

Xiong J. A ‘Nobel’ look at metabolism. Trends in Endocrinology and Metabolism 29, 809–813 (2018).

Xiong J. Fatty acid oxidation in cell fate determination. Trends in Biochemical Sciences 43, 854–857 (2018).

Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP and Xu Y. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Journal of Cell Biology 208(5): 513–520 (2015). (Editorially highlighted in Nature Reviews Molecular Cell Biology and Journal of Cell Biology).

Xiong J, Du Q and Liang Z. Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein. Oncogene 29(35): 4980–4988 (2010).

Contact for Research Inquiries

600 5th Street South
REB Bldg., Rm. 3111
St. Petersburg, FL 33701 map
Phone: 727-767-8926
Fax: 727-767-8804

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Activities & Honors

Honors

  • NHLBI Career Transition Award K22, National Institutes of Health (NIH), 2019 - 2024
  • Earl Stadtman Investigator Program Finalist, National Institutes of Health (NIH), 2019 - 2021
  • Summer Research Mentor Award, National Institutes of Health (NIH), 2019
  • Elected Member of NIH Immunology Interest Group Steering Committee, 2018 - 2019
  • Young Investigator Award, NIH Asian and Pacific Islander American Organization, 2018

Memberships

  • American Association of Immunologists
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