Dr. Xiong's laboratory studies the cytokine and metabolic regulation of cell fate and function, ranging from basic molecular mechanisms to human disease. Dr. Xiong's research aims to understand the mechanisms of how cytokine signaling and vascular-immune crosstalk contribute to physiology and pathophysiology, and to facilitate the development of new therapies for metabolic, cardiovascular and inflammatory diseases as well as cancer. Dr. Xiong’s laboratory uses systems cell biology and immunology approaches to identify novel molecular and cellular targets that can be harnessed for cell therapy, immunotherapy and drug discovery.
Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira, II, Brittain EL, Wolfgang MJ, Jurczk MJ, Fessel JP, Finkel T. A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Molecular Cell. 69(4):689–98 e7 (2018). (Editorially highlighted in Nature Reviews Molecular Cell Biology, Trends in Molecular Medicine and Trends in Endocrinology and Metabolism).
Xiong J. A ‘Nobel’ look at metabolism. Trends in Endocrinology and Metabolism 29, 809–813 (2018).
Xiong J. Fatty acid oxidation in cell fate determination. Trends in Biochemical Sciences 43, 854–857 (2018).
Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP and Xu Y. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Journal of Cell Biology 208(5): 513–520 (2015). (Editorially highlighted in Nature Reviews Molecular Cell Biology and Journal of Cell Biology).
Xiong J, Du Q and Liang Z. Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein. Oncogene 29(35): 4980–4988 (2010).