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Jessica Lea Klein, M.D.

Headshot of Jessica Lea Klein

Languages: English, Spanish


Neurology, Pediatric Headaches, Pediatric Neurology, Tic Disorders, Tourette's Syndrome more

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Johns Hopkins Health Care and Surgery Center

Appointment Phone: 410-955-4259
6420 Rockledge Drive
Johns Hopkins Children's Center Specialists, Suite 2300
Bethesda, MD 20817 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-4259
601 N. Caroline St.
5th Floor
Baltimore, MD 21287 map

The Johns Hopkins Hospital

Appointment Phone: 410-955-4259
600 N. Wolfe Street
Baltimore, MD 21287 map
Phone: 410-955-4259


Jessica Klein, M.D., is a pediatric neurologist who focuses on headaches in children.

Dr. Klein has specialized training in pediatric migraines and also sees patients with general child neurological conditions including epilepsy, tics, Tourette syndrome and cerebral palsy.

Dr. Klein sees patients at the Johns Hopkins Outpatient Center in Baltimore and at the Johns Hopkins Health Care and Surgery Center in Bethesda.

Dr. Klein earned her medical degree from the Virginia Commonwealth University School of Medicine and completed her pediatric neurology and general pediatrics training here at Johns Hopkins. Dr. Klein then served as assistant professor in the division of pediatric neurology at the Medical University of South Carolina before returning to Maryland. more

Departments / Divisions



  • University of Texas Medical School at San Antonio (2008)
  • MD; Virginia Commonwealth University Health System (2010)


  • Pediatrics; Johns Hopkins University School of Medicine (2012)
  • Pediatric Neurology; Johns Hopkins University School of Medicine (2015)

Board Certifications

  • American Board of Psychiatry and Neurology (Neurology/Special Child Neurology) (2015)

Research & Publications

Selected Publications

Comparative quantitative clinical, neuroimaging, and functional profiles in children with acute flaccid myelitis at acute and convalescent stages of disease. Gordon‐Lipkin, E. , Muñoz, L. S., Klein, J. L., Dean, J. , Izbudak, I. and Pardo, C. A. (2019), Dev Med Child Neurol, 61: 366-375. doi:10.1111/dmcn.14030

Gait Disturbance as the Presenting Symptom in Young Children With Anti-NMDA Receptor Encephalitis. Anusha K. Yeshokumar, Lisa R. Sun, Jessica L. Klein, Kristin W. Baranano, Carlos A. Pardo, Pediatrics 138(3) · August 2016.  DOI: 10.1542/peds.2016-0901

A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. Fahrner JA, Liu R, Perry MS, Klein J, Chan DC. Am J Med Genet A. 2016 Aug;170(8):2002-11. doi: 10.1002/ajmg.a.37721. Epub 2016 May 4.

Clinical and neuroimaging features as diagnostic guides in neonatal neurology diseases with cerebellar involvement. Jessica L. Klein, Monica E. Lemmon, Frances J. Northington, Eugen Boltshauser, Thierry A. G. M. Huisman, and Andrea Poretti Cerebellum Ataxias. 2016; 3: 1.  January 2016. doi:  10.1186/s40673-016-0039-1

Acute paraplegia in a preterm infant with cerebral sinovenous thrombosis. Janice Hobbs, Aylin Tekes, Jessica Klein, Monica Lemmon, Ryan Felling, Raul Chavez-Valdez. Journal of Perinatology 35(6):460-2.  June 2015. DOI:10.1038/jp.2015.26

Activities & Honors


  • Frank L. Coulson Resident Award in Clinical Excellence, Johns Hopkins Hospital, 2015
  • Executive Chief Resident, Division of Pediatric Neurology, Johns Hopkins Hospital, 2014


  • Child Neurology Society
  • American Academy of Neurology
  • American Medical Association
  • American Academy of Pediatrics

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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