Jeffrey Rothstein, M.D., Ph.D.

Jeffrey David Rothstein, M.D., Ph.D.

Headshot of Jeffrey Rothstein
  • Director, Robert Packard Center for ALS Research
  • Professor of Neurology


Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's Disease, Neurology, Neuromuscular Disease more

Research Interests

Various molecular mechanisms of selective neurodegeneration in motor neuron diseases such as amyotrophic lateral sclerosis; Identification of novel drug or peptide therapeutics to delay or prevent motor neuron degeneration in ALS through the use of cell culture and transgenic models of ALS; Use of neuronal and non-neuronal stem cell therapies to treat motor neurons diseases including ALS and Spinal Muscular Atrophy; Models of motor axon regeneration regrowth; Basic biology of glutamate transporters and their role in acute and chronic neuronal degeneration (e.g. ALS, epilepsy, stroke, spinocerebellar ataxia); Cloning and characterization of novel proteins which may be responsible for the cellular regulation of glutamate transporters. more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-614-5972
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287
The Johns Hopkins Hospital (Main Entrance) - Google Maps

Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-614-5972
601 N. Caroline St.
Baltimore, MD 21287
Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center) - Google Maps


Dr. Jeffrey Rothstein focuses on neuromuscular diseases, with a particular focus on Amyotrophic lateral sclerosis (ALS). Other clinical areas relevant to his laboratory-based research include: idiopathic stupor, epilepsy and motor neuron degeneration.

His laboratory includes more than 20-post doctoral fellows, neurology residents, neuromuscular and epilepsy fellows, undergraduate students, technicians and ALS clinic staff. He has been the principal and/or local investigator in eight national or international trials in ALS. He is the author of more than 100 articles on basic and clinical neuroscience. Dr. Rothstein's laboratory research is funded through the National Institutes of Health, the Muscular Dystrophy Association, the ALS Association and Project A.L.S.

Dr. Jeffrey Rothstein received a masters degree in neurochemistry from the University of Chicago and a Ph.D. in physiology and biophysics from the University of Illinois Health Sciences Center. He then obtained his medical degree from the University of Illinois College of Medicine. He went on to complete an internship at the University of North Carolina Memorial Hospital before joining The Johns Hopkins for his residency. While at Johns Hopkins, he became chief resident in neurology and completed his fellowship in neuromuscular disease. more


  • Director, Robert Packard Center for ALS Research
  • Professor of Neurology
  • Professor of Neuroscience

Departments / Divisions

Centers & Institutes



  • MD PhD; University of Illinois at Chicago (1985)


  • Neurology; Johns Hopkins University School of Medicine (1989)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (1990)

Research & Publications

Clinical Trial Keywords

Novel therapeutics in ALS

Videos & Media

Recent News Articles and Media Coverage

For ALS families, coping is real 'challenge', Louisville Times-Courier (08/31/2014)

Five myths about ALS, Washington Post (08/22/2014)

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