Jeannie-Marie Sheppard Leoutsakos, Ph.D.

Headshot of Jeannie-Marie Sheppard Leoutsakos
  • Director, Psychiatry Biostatistics and Methodology Core
  • Associate Professor of Psychiatry and Behavioral Sciences



  • Director, Psychiatry Biostatistics and Methodology Core
  • Associate Professor of Psychiatry and Behavioral Sciences

Departments / Divisions



  • Ph.D.; Johns Hopkins Bloomberg School of Public Health (Maryland) (2007)

Additional Training

  • Johns Hopkins University School of Medicine, Baltimore, Maryland, 2009, Geriatric Psychiatry and Neuropsychiatry

Research & Publications

Research Summary

My research involves the application of biostatistics to psychiatric research, both clinical and epidemiological. I am primarily interested in latent variable methods, including latent class analysis and growth mixture models which allow for the modeling of risk factors, treatment response, or outcomes as a function of latent class membership based on patterns of symptoms or shapes of trajectories over time.

Selected Publications

  1. Leoutsakos JS, Han D, Mielke MM, Forrester S, Tschanz JT, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Lyketsos CG.  Effects of general medical health on alzheimer progression:  the cache county dementia progression study.  International Psychogeriatrics.  In Press. [PMID: 22687143]
  2. Lee CT, Leoutsakos JS, Lyketsos CG, Steffens DC, Breitner JCS, Norton MC.  Latent class-derived depression subgroups in a community sample of older adults:  the cache county study.  International Journal of Geriatric Psychiatry.  In Press. [PMID:22135008]
  3. MacLean KA, Leoutsakos JS, Johnson MW, Griffiths RR.  Validation and factor analysis of a scale to measure mystical experience:  a study of experiences occasioned by the hallucinogen psilocybin.  Journal for the Scientific Study of Religion.  In Press.
  4. Leoutsakos JM, Muthen BO, Breitner JCS, Lyketsos CG.  Effects of NSAID treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease:  Findings from the randomized controlled ADAPT trial.  International Journal of Geriatric Psychiatry. 2012 Apr;27(4):364-74. [PMID: 21560159]
  5. Leoutsakos JS, Bandeen-Roche K, Garrett-Mayer E, Zandi PP.  Incorporating scientific knowledge into phenotype development:  penalized latent class regression. Statistics in Medicine 2011 Mar; 30(7):784-798. [PMID:21394753]

Contact for Research Inquiries

Johns Hopkins Bayview Medical Center
Alpha Commons Building
5300 Alpha Commons Drive
Baltimore, MD 21224 map
Phone: 410-550-9884

Email me

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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