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410-955-9441

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410-464-6641
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+1-410-502-7683
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Locations

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-9441
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-5000 | Fax: 410-614-9830

Background

Dr. Chua is an assistant professor in the Department of Neurology and Division of Movement Disorders at  Johns Hopkins. He received his training at the University of Michigan, where he obtained medical and graduate degrees, then completed a residency in neurology and a combined clinical/research fellowship in movement disorders and neurodegeneration.

Dr. Chua’s primary research interests are in neurodegenerative disease with a special focus on autophagy — an essential housekeeping process in cells that is particularly important for the health of neurons. Autophagy may provide a way to break down the buildup of toxic proteins found in neurodegenerative diseases, thereby forming the basis of new treatment strategies for these incurable conditions. He has received multiple research grants to support his work, including from the National Institute of Neurological Disorders and Stroke and the American Academy of Neurology (AAN).

He is the primary author and co-author of multiple peer-reviewed scientific publications and online learning modules as part of the AAN. Dr. Chua is a contributing author to The Little Black Book of Neurology by Osama Zaidat, Alan Lerner and J. Douglas Miles, and he has been a peer reviewer for the scientific journals Autophagy, eLife and Neurobiology of Disease. He currently serves on the scientific advisory board for the Don't Forget Morgan Foundation, a private organization supporting research and outreach regarding the disease beta-propeller protein-associated neurodegeneration (BPAN).

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Titles

  • Assistant Professor of Neurology

Departments / Divisions

Education

Degrees

  • MD PhD; Medicine; University of Michigan Medical School (2015)

Residencies

  • Neurology; University of Michigan Health System (2019)

Fellowships

  • Movement Disorders; University of Michigan Health System (2021)

Board Certifications

  • American Board of Psychiatry and Neurology (Neurology-General) (2019)

Research & Publications

Selected Publications

View all on PubMed

Chua JP, Bedi K, Paulsen MT, Ljungman M, Tank EMH, Kim ES, Colon-Mercado JM, Ward ME, Weisman LS, Barmada SJ. Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons. (2021) bioRxiv 2021.07.20.453106

Chua JP, de Calbiac H, Kabashi E, Barmada SJ. Autophagy and ALS: Mechanistic insights and therapeutic implications. (2021) Autophagy 2021:1-29

Chua J, Nafziger E, Leung D. Evidence-Based Practice: Temozolomide Beyond Glioblastoma. (2019) Curr Oncol Rep 21:30

Chua JP, Reddy SL, Yu Z, Giorgetti E, Montie HL, Mukherjee S, Higgins J, McEachin RC, Robins DM, Merry DE, Iniguez-Llhui JA, Lieberman AP. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease. (2015) J Clin Invest 125:831-45

Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. (2014) Hum Mol Genet 23:1376-86

Contact for Research Inquiries

Institute for Cell Engineering
733 North Broadway
Edward D. Miller Research Building
Baltimore, MD 21205 map

Activities & Honors

Memberships

  • American Academy of Neurology
  • Movement Disorders Society
  • Society for Neuroscience
  • American Physician Scientists Association
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