J Raymond DePaulo JR, M.D.

Headshot of J Raymond DePaulo JR
  • University Distinguished Service Professor
  • Professor of Psychiatry and Behavioral Sciences


Adult Psychiatry, Affective Disorders, Bipolar Disorder, Depression, Mood Disorders, Psychiatry, Psychiatry and Behavioral Sciences ...read more

Research Interests

Bipolar Disorders, Depression

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Phone: 410-955-3130


J. Raymond DePaulo, Jr., M.D. is a University Distinguished Service Professor and Co-Director of the Mood Disorder Center in the Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine. He has been an active clinician, teacher, researcher throughout his 39 years on the Johns Hopkins faculty. He founded the Hopkins Affective Disorders Clinic in 1977 and grew it into a multifaceted program that led patient care, teaching and research on depression and bipolar disorder at Johns Hopkins. Dr. DePaulo was the Henry Phipps Professor and Director of the Department of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine and Psychiatrist in Chief at the Johns Hopkins Hospital from 2002 until 2016.

Dr. DePaulo’s research interests focus on clinical assessment, diagnosis, causes and treatments of mood disorders. His research group led several early genetic studies of bipolar disorder and unipolar depression. He has authored over 140 peer-reviewed scientific articles and mentored outstanding clinician scientists (notably Francis J. McMahon, M.D. of the Genetic Basis of Mood and Anxiety Disorders Unit at NIMH; James B. Potash, M.D., M.P.H., Professor and Department Head of Psychiatry at University of Iowa Carver College of Medicine; and Melvin G. McInnis, M.D., Upjohn-Woodworth Professor of Psychiatry at the University of Michigan).  Dr. DePaulo worked with Dr. Karen Swartz who leads the Adolescent Depression Awareness Program (ADAP), which developed, teaches and studies a model curriculum on depression for high schools. He has partnered with Dr. Kay Jamison in research, education and advocacy efforts for patients and families.

Dr. DePaulo is now the Chairperson of the Board of Directors of the National Network of Depression Centers (NNDC.org). He has served on several foundation boards of directors and scientific advisory boards related to mood disorders. Dr. DePaulo has authored two books on depressive illnesses for patients and families (Understanding Depression and How to Cope with Depression).  He has won a number of national awards for clinical leadership, teaching, and  research in depression and bipolar disorder. He has twice been named a Forum Fellow at the World Economic Forum held annually in Davos, Switzerland.

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  • University Distinguished Service Professor
  • Co-Director of the Mood Disorder Center
  • Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Centers & Institutes



  • MD; Johns Hopkins University School of Medicine (1972)


  • Psychiatry; Johns Hopkins Bayview Medical Center (1974)
  • Psychiatry; Johns Hopkins University School of Medicine (1977)

Board Certifications

  • American Board of Psychiatry And Neurology (Psychiatry) (1977)

Research & Publications

Selected Publications

Nwulia EA, Miao K, Zandi PP, Mackinnon DF, DePaulo JR, McInnis MG. Genome-wide scan of bipolar II disorder. Bipolar Disord. 6: 580-8, 2007.

Verma R, Cutler DJ, Holmans P, Knowles JA, Crowe RR, Scheftner WA, Weissman MM, DePaulo JR Jr, Levinson DF, Potash JB. Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression. American Journal of Medical Genetics (Neuropsychiatric Genetics) 144:1079-82, 2007.

Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ; NIMH Genetics Initiative Bipolar Disorder Consortium. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1. American Journal of Medical Genetics (Neuropsychiatric Genetics). 147: 59-67, 2008.

Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, Mackinnon DF, Mondimore FM, Schweizer B, Depaulo JR Jr, Gershon ES, McMahon FJ, Potash JB. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry. 14: 261268, 2009.

Payne JL, MacKinnon DF, Mondimore FM, McInnis MG, Schweizer B, Zamoiski RB, McMahon FJ, Nurnberger JI Jr, Rice JP, Scheftner W, Coryell W, Berrettini WH, Kelsoe JR, Byerley W, Gershon ES, DePaulo JR, Potash JB. Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disord. 10: 38-44,2008.

Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, Scheftner WA, Weissman MM, Depaulo JR Jr, Potash JB, Levinson DF. Linkage Disequilibrium Mapping of a Chromosome 15q25-26 Major Depression Linkage Region and Sequencing of NTRK3. Biological Psychiatry. 63:1185-9, 2008.

Langlieb AM, DePaulo JR, Etiology of depression and implications on work environment. Journal of Occupational Environmental Medicine. 391-5, 2008.

Barton CD, DePaulo JR, The unrecognized costs of delirium. Nature Clinical Practice Neurology. 4:233, 2008. [Editorial]

Zandi PP, Belmonte PL, Willour VL, Goes FS, Badner JA, Simpson SG, Gershon ES, McMahon FJ, DePaulo JR
Potash JB; Association study of Wnt signaling pathway genes in bipolar disorder. Bipolar Disorder Phenome Group; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Archives of General Psychiatry. 65: 785-93, 2008.

Nwulia EA, Zandi PP, McInnis MG, DePaulo JR, MacKinnon DF. Rapid switching of mood in families with familial bipolar disorder. Bipolar Disord. 10: 597-606, 2008.

Payne JL, Klein SR, Zamoiski RB, Zandi PP, Bienvenu OJ, Mackinnon DF, Mondimore FM, Schweizer B, Swartz KL; Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees. NIMH Genetics Initiative Bipolar Disorder Consortium, Crowe RP, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR, Potash JB. Archives of Women's Mental Health.12: 27-34, 2009

Activities & Honors


  • Outstanding New Research, National Depressive and Manic Depressive Association, 1989
  • Alpha Omega Alpha, (elected alumnus chapter), 1991
  • Public Education Award, The 1992 NIMH - D/ART, 1992
  • Harriett and Milton Parker Lecture in Psychiatric Genetics, Ohio State University, 1995
  • SELO Prize, for outstanding research on depression, National Association for Research in Schizophrenia and Depression (NARSAD), 1996
  • Samuel Guze Lecture, Washington University, 2002
  • Research Award, American Foundation for Suicide Prevention, 2007


  • American Foundation for Suicide Prevention
  • Depression and Bipolar Support Association
  • National Association for Research in Schizophrenia and Depression

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