Isam Waddah Nasr, M.D.

Headshot of Isam Waddah Nasr
  • Director of Pediatric Trauma Program, Division of Pediatric Surgery
  • Assistant Professor of Surgery

Languages: English, Arabic, French


Chest Wall Reconstruction, Critical Care Medicine, General Surgery, Minimally Invasive Pediatric Surgery, Minimally Invasive Surgery, Neonatal Congenital Anomalies, Neonatal Surgery, Pectus Carinatum, Pectus Excavatum, Pediatric Gastroenterology, Pediatric General Surgery, Pediatric Oncology Surgery, Pediatric Surgery, Pediatric Trauma, Robotic Surgery, Thoracic Surgery, Trauma Surgery more

Research Interests

inflammatory response to traumatic brain injury; pediatric trauma simulation; outcomes in pediatric trauma; pediatric injury prevention more

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Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 443-997-5437
1800 Orleans Street
The Charlotte R. Bloomberg Children's Center Building, Suite 7323
Baltimore, MD 21287
The Johns Hopkins Hospital (Main Entrance) - Google Maps

York – WellSpan

Appointment Phone: 717-812-4390
300 Pine Grove Commons
Suite 300
York, PA 17403
York – WellSpan - Google Maps


Isam Nasr is a pediatric trauma surgeon within the Johns Hopkins Department of Surgery and Johns Hopkins Children's Center.

Dr. Nasr specializes in the advanced treatment of trauma and critical care injuries among children. He is trained in both robotic and minimally invasive surgical procedures, and is skilled in the management of congenital colorectal anomalies.

He comes to Johns Hopkins from the Children’s Hospital of Pittsburgh of UPMC, where he completed fellowships in both surgical critical care and pediatric surgery. Dr. Nasr’s basic science research interests include studying the inflammatory response following traumatic brain injury in the pediatric population. His clinical focus will be on implementing systems-based methods to improve the care of the pediatric trauma patient. more


  • Director of Pediatric Trauma Program, Division of Pediatric Surgery
  • Co-Director of the Pediatric Surgical Colorectal Program
  • Assistant Professor of Surgery

Departments / Divisions

Centers & Institutes



  • MD; American University of Beirut Faculty of Medicine (2003)


  • General Surgery; University of Pittsburgh Medical Center (2012)


  • Pediatric Surgical Critical Care; University of Pittsburgh Medical Center (2013)
  • Pediatric Surgery; University of Pittsburgh Medical Center (2015)

Board Certifications

  • American Board of Surgery (General Surgery) (2013)
  • American Board of Surgery (Pediatric Surgery) (2016)
  • American Board of Surgery (Surgical Critical Care) (2014)

Research & Publications

Selected Publications

Saade NE, Nasr IW, Massaad CA, Safieh-Garabedian B., Jabbur SJ, Kanaan SA. Modulation of ultraviolet-induced hyperalgesia and cytokine upregulation by interleukins 10 and 13.  British Journal of Pharmacology. 2000;131(7):1317-24.

Baddoura FK, Nasr IW, Wrobel B, Ruddle NH, Lakkis FG. Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection. American Journal of Transplantation. 2005;5(3): 510-516.

Dai Z, Nasr IW, Reel M, Smith-Diggs L, Larsen CP, Rothstein DM, Lakkis FG. Impaired recall of CD8 memory T cells in immunologically privileged tissue. Journal of Immunology. 2005;174(3):1165-70. 

Nasr IW, Wang Y, Deng S, Li Q, Smith-Diggs L, Rothstein DM, Tellides G, Lakkis FG, Dai Z. Testicular Immune Privilege Promotes Transplantation Tolerance by Tipping the Balance Between Pathogenic Memory and Regulatory T Cells. Journal of Immunology. 2005;174 (10): 6161-68.

Nasr IW *, Walker WE*, Camirand G, Tesar BM, Booth CJ, Goldstein DR. (*Co-first Authors) Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance. Journal of Immunology. 2006;177(8):5307-16

Nasr IW, Reel M, Oberbarnscheidt MH, Mounzer RH, Baddoura FK, Ruddle NH, Lakkis FG. Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection. American Journal of Transplantation. 2007;7(5):1071-9 

Jindal R, Sucher R, Wang Y, Weinstock M, Pulikkottil BJ, Nasr IW, Zanoun R, Brandacher G. the Immunoregulatory Role of CD200 in Composite Tissue Allotransplantation. Plastic and Reconstructive Surgery. 2010;125(6):32.

Hautz T, Zelger BG, Nasr IW, Mundinger GS, Barth RN, Rodriguez ED, Brandacher G, Weissenbacher A, Zelger B, Cavadas P, Margreiter R, Lee WP, Pratschke J, Lakkis FG, Schneeberger S. Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts. Transplant International. 2014;27(9):966-76 

Activities & Honors


  • Young Investigator Award for the American Transplant Congress (ATC), American Transplant Congress (ATC), 2007 - 2010
  • Distinguished Fellows Research Forum Travel Award, American Society of Transplantation, 2002 - 2009
  • Research Scholarship Award, American College of Surgeons, 2006 - 2010


  • American Pediatric Surgical Association, 2014
  • Pediatric Trauma Society, 2015
  • American Pediatric Surgical Association, Trauma Committee, 2015
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