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Heba Mostafa, M.B.B.Ch., Ph.D.

Heba Mostafa, M.B.B.Ch., Ph.D.

Headshot of Heba Mostafa
  • Director, Molecular Virology Laboratory, The Johns Hopkins Hospital
  • Associate Professor of Pathology

Research Interests

Genomic surveillance of viruses and the correlation between viral evolution and disease severity. Understanding the respiratory virome and developing personalized molecular diagnostic panels for immunocompromised populations. Implementing innovative molecular diagnostics in the clinical microbiology laboratory ...read more

Background

Dr. Heba Mostafa completed her M.D. at the Faculty of Medicine, Alexandria University, Egypt.  She then moved to the United States where she earned her Ph.D. in Microbiology at the University of Kansas (Lawrence, KS) followed by three years of Post-Doctoral Research Fellowship at St. Jude Children’s Research Hospital (Memphis, TN).  Dr. Mostafa completed her Clinical Microbiology Fellowship training at the University of Rochester Medical Center (Rochester, NY) and earned her ABMM certification.  Dr. Mostafa currently serves as an Associate Professor of Pathology at Johns Hopkins school of Medicine and the Director of the Molecular Virology Laboratory at Johns Hopkins Hospital. Dr. Mostafa’s research program focuses on implementing whole genome sequencing in the Molecular Virology Laboratory with applications that include: genomic surveillance of viruses and the correlation between viral evolution and disease severity, understanding the respiratory virome, and developing personalized molecular diagnostic panels for immunocompromised patients.

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Titles

  • Director, Molecular Virology Laboratory, The Johns Hopkins Hospital
  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • M.B.B.Ch.; Alexandria University, Faculty of Medicine (Egypt) (2004)
  • Ph.D.; University of Kansas (Kansas) (2014)

Research & Publications

Selected Publications

View all on PubMed

Luo CH, Morris CP, Sachithanandham J, Amadi A, Gaston D, Li M, Swanson NJ, Schwartz M, Klein EY, Pekosz A, Mostafa HH. Infection with the SARS-CoV-2 Delta Variant is Associated with Higher Recovery of Infectious Virus Compared to the Alpha Variant in both Unvaccinated and Vaccinated Individuals. Clin Infect Dis. 2021 Dec 18:ciab986. doi: 10.1093/cid/ciab986. Online ahead of print. PMID: 34922338

Amary Fall, Raghda E Eldesouki, Jaiprasath Sachithanandham, C Paul Morris, Julie M Norton, David C Gaston, Michael Forman, Omar Abdullah, Nicholas Gallagher, Maggie Li, Nicholas J Swanson, Andrew Pekosz, Eili Y Klein, Heba H Mostafa. The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads. EBioMedicine. 2022 Apr 20;79:104008. doi: 10.1016/j.ebiom.2022.104008

Katharine Uhteg, Adannaya Amadi, Michael Forman, Heba H Mostafa. Circulation of Non- SARS-CoV-2 Respiratory Pathogens and Coinfection with SARS-CoV-2 Amid the COVID-19 Pandemic. Open Forum Infect Dis. 2021 Dec 8;9(3):ofab618. doi: 10.1093/ofid/ofab618

C. Paul Morris, Chun Huai Luo, Jaiprasath Sachithanandham, Maggie Li, Matthew Schwartz, David C Gaston, Victoria Gniazdowski, Nicolas Giraldo-Castillo, Adannaya Amadi, Julie M Norton, William F Wright, Eili Y Klein, Andrew Pekosz and Heba H Mostafa. Large Scale SARS-CoV-2 Molecular Testing and Genomic Surveillance Reveal Prolonged Infections, Protracted RNA shedding, and Viral Reinfections

Morris CP, Luo CH, Amadi A, Schwartz M, Gallagher N, Ray SC, Pekosz A, Mostafa HH. An Update on SARS-CoV-2 Diversity in the United States National Capital Region: Evolution of Novel and Variants of Concern. Clin Infect Dis. 2021 Jul 17:ciab636. doi: 10.1093/cid/ciab636. Online ahead of print. PMID: 34272947

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