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Background

Dr. Gyanu Lamichhane is an Associate Professor in the Division of Infectious Diseases, Johns Hopkins University School of Medicine. His research focuses on the bacterial cell wall physiology in relevance to diseases in humans. He studies basic mechanisms associated with cell walls, but with an intent to leverage findings to develop tools that will be useful in the clinic. His group devotes significant effort on developing new strategies to treat mycobacterial diseases. Additionally, a new and significant effort of his research is fundamental but understudied mechanisms that lead to antibacterial resistance.

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Titles

  • Associate Professor of Medicine

Departments / Divisions

Education

Degrees

  • Ph.D.; Johns Hopkins University School of Medicine (Maryland) (2004)
  • B.A.; Wabash College (Indiana) (1999)

Research & Publications

Lab

Lab Website: Lamichhane Lab

Selected Publications

Gupta R, Lavollay M, Mainardi J, Arthur M, Bishai WR, Lamichhane G. The Mycobacterium tuberculosis gene, ldtMt2, encodes a non-classical transpeptidase required for virulence and resistance to amoxicillin. Nature Medicine. 2010; 16, 466-9. PMID:20305661

Maggioncalda EC, Story-Roller E, Mylius J, Illei P, Basaraba RJ, Lamichhane G. A mouse model of pulmonary Mycobacteroides abscessus infection. 2020. Scientific Reports. 10. PMID 32111900

Story-Roller E, Maggioncalda EC, Lamichhane G. Select β-lactam combinations exhibit synergy against Mycobacterium abscessus in vitro. 2019. Antimicrobial Agents and Chemotherapy. 63 (4) e02613-18 PMID 30745389

Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Ammerman NC, Lloyd DT, Perryman AL, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G. New antibacterials targeting non-classical transpeptidases. Nature Chemical Biology. 2017. 13; 54-61. PMID 27820797

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