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Franco Rafael D'Alessio, M.D.

Franco Rafael D'Alessio, M.D.

Headshot of Franco Rafael D'Alessio
  • Associate Professor of Medicine

Languages: English, Spanish


Pulmonary and Critical Care Medicine

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Outside of Maryland & Washington D.C.

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-4887 | Fax: 410-550-2612

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-550-5864
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map


Dr. D’Alessio focuses on caring for critically ill patients with particular interest in acute respiratory failure and patients with sepsis. His translational focus is in identifying changes in the immune cell landscape in pulmonary and critical care pathologies.

Dr. D'Alessio earned his M.D. from Universidad Peruana Cayetano Heredia. He completed his residency at Johns Hopkins. He performed a fellowship at the Institute Tropical Medicine Alexander Von Humboldt and a fellowship in pulmonary and critical care medicine at Johns Hopkins.

His research interests include mechanisms underlying resolution of lung inflammation and injury and interactions between alveolar macrophages and regulatory T cells. more


  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Universidad Peruana Cayetano Heredia (2000)


  • Internal Medicine; Johns Hopkins University School of Medicine (2004)


  • Institute Tropical Medicine Alexander Von Humboldt (2001)
  • Pulmonary and Critical Care Medicine; Johns Hopkins University School of Medicine (2008)

Board Certifications

  • American Board of Internal Medicine (Critical Care Medicine) (2011)

Research & Publications

Research Summary

Our laboratory has focused in studying immunological mechanisms underlying resolution of lung inflammation and injury. We found a critical role for Regulatory T cells (Tregs) and pro-repair macrophages in controlling excessive innate immune responses in the lung to mediate resolution of lung injury. We found that resolution of lung inflammation is an active process, distinct from early injury, in which Tregs cellular interactions with alveolar macrophages, alveolar epithelium, and other lymphocytes orchestrate a series of events that ultimately lead to lung repair. While cell-based therapy using Tregs represents a therapeutic strategy for acute respiratory distress syndrome (ARDS), endogenous Treg control mechanisms to augment their pro-repair function represents a more feasible approach to enhance resolution and improve ARDS outcomes.

Contact for Research Inquiries

Lung Injury and Repair Laboratory
5501 Hopkins Bayview Circle Room 4A-62
Baltimore, MD 21224 map

Activities & Honors

Professional Activities

  • Associate editor for Journal of Clinical Investigation
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