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Tumor immune microenvironment; immune checkpoints Microbiome; colorectal cancer IL-17; colon cancer ...read more
Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Sadtler K, Estrellas K, Allen BW, Wolf MT, Fan H, Tam AJ, Patel CH, Luber BS, Wang H, Wagner KR, Powell JD, Housseau F, Pardoll DM, Elisseeff JH. Science. 2016 Apr 15;352(6283):366-70. doi: 10.1126/science.aad9272
Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis. Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F. Cancer Discov. 2015 Oct;5(10):1098-109. doi: 10.1158/2159-8290.CD-15-0447. Epub 2015 Jul 22
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, Anders RA, Pardoll DM, Housseau F.
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL. Nat Med. 2009 Sep;15(9):1016-22. doi:10.1038/nm.2015. Epub 2009 Aug 23.
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Chan CW, Crafton E, Fan HN, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky TW, Stins MF, Lanier LL, Pardoll DM, Housseau F. Nat Med. 2006 Feb;12(2):207-13. Epub 2006 Jan 29