Research Summary
My research interest is the immunomodulation of the tumor microenvironment to improve the response to immunotherapy. I am studying the roles of the microbiome, tissue regeneration and aging onto the immune response to cancer, aiming at developing new therapeutic tools (bacteria, senescent cells, affinity matured TCR) to improve the clinical response to immune checkpoint blockade.
Lab
Lab Website: Housseau Research Group
Selected Publications
View all on PubMed
DeStefano Shields CE, White JR, Chung L, Wenzel A, Hicks JL, Tam AJ, Chan JL, Dejea CM, Fan H, Michel J, Maiuri AR, Sriramkumar S, Podicheti R, Rusch DB, Wang H, De Marzo AM, Besharati S, Anders RA, Baylin SB, O'Hagan HM, Housseau F, Sears CL. Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy. Cancer Discov. 2021 Jul;11(7):1792-1807. doi: 10.1158/2159-8290.CD-20-0770. PubMed PMID: 33632774. PMCID: PMC8295175
Lu Z, Zou J, Li S, Topper MJ, Tao Y,Zhang H, Jiao X, Xie W, Kong X, Vaz M, Li H, Cai Y, Xia L, Huang P, Rodgers K, Lee B, Riemer JB, Day CP, Yen RC, Cui Y, Wang Y, Wang Y, Zhang W, Easwaran H, Hulbert A, Kim K, Juergens RA, Yang SC, Battafarano RJ, Bush EL, Broderick SR, Cattaneo SM, Brahmer JR, Rudin CM, Wrangle J, Mei Y, Kim YJ, Zhang B, Wang KK, Forde PM, Margolick JB, Nelkin BD, Zahnow CA, Pardoll DM, Housseau F, Baylin SB, Shen L,Brock MV. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020 Mar;579(7798):284-290. doi: 10.1038/s41586-020-2054-x. PubMed PMID: 32103175; PMCID: PMC8765085
Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J,Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F. Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5. doi: 10.1016/j.chom.2018.01.007. PubMed PMID: 29398651; PMCID: PMC5954996
Llosa NJ, Cruise M, Tam A,Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, Anders RA, Pardoll DM, Housseau F. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov. 2015 Jan;5(1):43-51. doi: 10.1158/2159-8290.CD-14-0863. PubMed PMID: 25358689; PMCID: PMC4293246
Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009 Sep;15(9):1016-22. doi: 10.1038/nm.2015. PubMed PMID: 19701202; PMCID: PMC3034219
