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Francis Michael Giardiello, M.D.

Headshot of Francis Michael Giardiello
  • Professor of Medicine


Clinical Gastroenterology, Colon Cancer, Colon Polyps, Digestive Disorders, Family History of Cancer, Gastroenterology, Gastrointestinal Cancers, Hereditary Colorectal Cancer, Rectal Bleeding more

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The Johns Hopkins Hospital

Appointment Phone: 410-933-7495
600 N. Wolfe Street
Baltimore, MD 21287 map
Phone: 410-583-2888


Dr. Giardiello graduated from Tufts University School of Medicine and has a MBA from Johns Hopkins University. He received his internal medicine training at The University of Michigan and fellowship training in Gastroenterology at The Johns Hopkins Hospital. Presently, he is the Johns G. Rangos, Sr. Professor of Medicine, the program director for the gastrointestinal fellowship and directs the Johns Hopkins Colorectal Cancer Registry and Risk Assessment Clinic. He served for 9 years as the Director of the Division of Gastroenterology at Johns Hopkins University.

Dr. Giardiello's clinical and research interests have focused on the study of cancer and cancer chemoprevention in the gastrointestinal tract. This has included the investigation of the genetic basis of familial colorectal cancer and the use of genetic testing in the hereditary forms of colorectal cancer. He has a continuing interest in the study of the genotypic phenotypic correlations in the polyposis syndromes which include familial adenomatous polyposis, juvenile polyposis and Peutz-Jeghers syndrome.

In April 2017, Dr. Giardiello was elected to the Association of American Physicians. more


  • Professor of Medicine
  • Professor of Oncology
  • Professor of Pathology

Departments / Divisions

Centers & Institutes



  • MD; Tufts University School of Medicine (1980)


  • Internal Medicine; University of Michigan Health System (1983)


  • Gastroenterology; Johns Hopkins University School of Medicine (1985)
  • Gastroenterology; Johns Hopkins University School of Medicine (1986)

Board Certifications

  • American Board of Internal Medicine (Gastroenterology) (1985)
  • American Board of Internal Medicine (Internal Medicine) (1983)

Research & Publications

Research Summary

The study of the genotypic-phenotypic correlations and biomarkers in the polyposis syndromes and hereditary colorectal cancer, the investigation of the genetic basis of familial colorectal cancer, and the use of genetic testing in the hereditary forms of colorectal cancer.  Also, I conducted chemoprevention trials in hereditary colon cancer syndromes.

Selected Publications

1. Giardiello FM, Welsh SB, Offerhaus GJA, Booker SV, Krush AJ, HamiltonSR, Yardley JH, Luk GD. Increased risk of cancer in Peutz‑Jeghers syndrome. N Engl J Med 1987;316:1511‑14.

2. Giardiello FM, Hamilton SR, Krush AJ. Piantadosi S, Hylind LM, Celano P, Booker SV, Robinson CR, Offerhaus GJA. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 1993; 328:1313-6.

3.  Powell SM, Petersen GM, Krush AJ, Booker SV, Jen J, Giardiello FM, Hamilton SR, Vogelstein B, Kinzler KW. Molecular Diagnosis of familial adenomatous polyposis. N Engl J Med 1993;329:1982-7.

4.  Giardiello FM, Brensinger JD, Petersen GM, Luce MC, Hylind LM, Bacon JA, Booker SV, Parker RD, Hamilton SR. The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med 1997;336:823-7.

5.  Giardiello FM, Yang VW, Hylind LM, Krush AJ, Petersen GM, AJ, Trimbath JD, Piantadosi S, Garrett E, Geiman D, HubbardW, Offerhaus GJA, Hamilton SR.  Primary chemoprevention in familial adenomatous polyposis. NewEngland Journal of Medicine 2002;346:1046-9.

Activities & Honors


  • Electee, Association of American Physicians, 2017

Videos & Media

Recent News Articles and Media Coverage

Biofilm Holds Clue to Colon Cancer, Inside Tract (Summer, 2016)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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