Research Summary
Dr. Vesuna’s primary research interest is in the field of breast cancer development with a focus metastatic progression. He has worked on deciphering the role of the TWIST1 gene and it’s targets in breast cancer, such as the estrogen receptor and E-cadherin.
Dr. Vesuna is also involved in studying the role of the DDX3X gene in breast, lung, prostate, and brain cancer development as well as developing chemotherapeutic molecules for targeting this gene in various cancers.
Technology Expertise Keywords
Biochemistry, Cell Biology, Molecular Biology
Selected Publications
View all on PubMed
Genomic pathways modulated by Twist in breast cancer. Vesuna F, Bergman Y, Raman V. BMC Cancer. 2017 Jan 13;17(1):52.
RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3. Xie M, Vesuna F, Tantravedi S, Bol GM, Heerma van Voss MR, Nugent K, Malek R, Gabrielson K, van Diest PJ, Tran PT, Raman V. Cancer Res. 2016 Nov 1;76(21):6340-6350.
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor alpha. Vesuna F, Lisok A, Kimble B, Domek J, Kato Y, van der Groep P, Artemov D, Kowalski J, Carraway H, van Diest P, Raman V. Oncogene. 2012 Jul 5;31(27):3223-34
Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression. Vesuna F, Lisok A, Kimble B, Raman V. Neoplasia. 2009 Dec;11(12):1318-28
Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Vesuna F, van Diest P, Chen JH, Raman V. Biochem Biophys Res Commun. 2008 Mar 7;367(2):235-41
Patents
Compositions and Methods for Characterizing Breast Cancer
Patent # US Pat. 20,130,059,903 | 01/01/2013
Compositions and Methods for Characterizing Breast Cancer
Patent # WO Pat. 2,011,113,047 | 01/01/2011
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