Dr. Graham has a long history of research in the area of perinatal brain injury that involves both basic science and clinical work. Past research includes neuronal cell membrane Na+,K+-ATPase damage following hypoxia-ischemia in animal models, risk factors for seizures and periventricular white matter in the neonate, and the relationship between severe intrapartum metabolic acidosis, electronic fetal heart rate monitoring and neurologic morbidity and mortality. Current research involves using biomarkers measured in cord blood at birth and in neonatal serum during the 1st week of life to identify neonates at risk for neurodevelopmental abnormalities and to follow the efficacy of new therapies such as whole body cooling for hypoxic-ischemic encephalopathy.
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Peer-reviewed scientific articles:
Wayock CP, Meserole RL, Saria S, Jennings JM, Huisman TAGM, Northington FJ, Graham EM. Perinatal risk factors for severe injury in neonates treated with whole-body hypothermia for encephalopathy. Am J Obstet Gynecol 2014;211:41.e1-8.
Stewart A, Tekes A, Huisman TA, Jennings JM, Allen MC, Northington FJ, Everett AD, Graham EM. Glial fibrillary acidic protein as a biomarker for periventricular white matter injury. Am J Obstet Gynecol 2013;209:27.e1-7.
Rhee CJ, Kibler KK, Brady KM, Everett AD, Graham EM, Andropoulos DB, Easley RB. Detection of neurologic injury using vascular reactivity monitoring and glial fibrillary acidic protein. Pediatrics 2013;131:e950-4.
Ennen CS, Huisman TA, Savage WJ, Northington FJ, Jennings JM, Everett AD, Graham EM. Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole body cooling. Am J Obstet Gynecol 2011;205:251.e1-7.
Al-Hussein HA, Graham EM, Tekes A, Huisman TA. Pre and postnatal imaging of a congenital hepatoblastoma. Fetal Diagn Ther 2011;30:157-9.
Bembea MM, Savage W, Strouse JJ, Schwartz JM, Graham E, Thompson CB, Everett A. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Car Med 2011;12:572-9.
Northington FJ, Chavez-Valdez R, Graham EM, Razdan S, Gauda EB, Martin LJ. Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab 2011;31:178-89.
Stewart A, Graham E. Preterm Birth: An Overview of Risk Factors and Obstetrical Management. Dev Disabil Res Rev. 2010;16:285-88.
Figueiredo G, Pinto PS, Graham EM, Huisman TA. Congenital giant cervical teratoma: pre- and postnatal imaging. Fetal Diagn Ther 2010;27:231-2.
Elliott C, Warrick PA, Graham EM, Hamilton EF. Graded classification of fetal heart rate tracings: association with neonatal metabolic acidosis and neurologic morbidity. Am J Obstet Gynecol 2010;202:258.e1-8.
- Holcroft CJ, Graham EM, Penning DH. In response to: Cord gas analysis, decision-to-delivery interval, and the 30 minute rule for emergency cesareans. J Perinatol 2005;25(9):616.
- Graham EM, Petersen SM, Fox HE. In response to: Intrapartum electronic fetal heart rate monitoring and the prevention of perinatal brain injury. Obstet Gynecol 2006;108:1554.
- Graham EM. Comment on “Elevated uterine activity increases the risk of fetal acidosis at birth.” Am J Obstet Gynecol 2007;197:441.
- Graham EM, Thompson RE. Reply concerning “Intrapartum electronic fetal heart rate monitoring and the identification of metabolic acidosis and hypoxic-ischemic encephalopathy.” Am J Obstet Gynecol 2008;198:343-4.
Selected Book Chapters, Monographs
Birsner M, Graham EM. Chapter 15: Cardiopulmonary Disorders of Pregnancy. In Hurt KJ, Guile JL, Bienstock JL et al, eds. The Johns Hopkins Manual of Gynecology and Obstetrics. 4th Edition. Philadelphia: Lippincott Williams & Wilkins, 2011: 195-207.
Ennen CS, Graham EM. Obstetric Factors Related to Perinatal Brain Injury. In Zimmerman AW, Connors SL eds. Maternal Influences on Fetal Neurodevelopment. New York: Springer, 2010: 79-95.
Graham EM, Larma JD. Abnormal fetal heart rate in labor. In Adams Hillard PJ ed. The 5-Minute Obstetrics and Gynecology Consult. Philadelphia: Lippincott Williams & Wilkins, 2008: 560-1.
Davidson S, Graham EM. Chapter 15: Cardiopulmonary Disorders of Pregnancy. In Fortner KB, Szymanski LM, Fox HE, Wallach EE, eds. The Johns Hopkins Manual of Gynecology and Obstetrics. 3rd Edition. Philadelphia: Lippincott Williams & Wilkins, 2007: 192-203.
Holcroft CJ, Graham EM. Peripartum Cardiomyopathy. Postgraduate Obstetrics & Gynecology. Vol. 24, No.15, July 2004.
Graham EM. Hypoxic-Ischemic Brain Injury in the Fetus and Neonate. Postgraduate Obstetrics & Gynecology. Vol. 24, No. 8, April 2004.