Technology Expertise Keywords
Fetal surgery; Fetal Intervention; Pediatric Enhanced Recovery after Surgery
Clinical Trial Keywords
Bilateral Renal Agenesis, Serial Amnioinfusions, Congenital Bilateral Renal Agenesis, CoBRA, Renal Ageneis Fetal Therapy, RAFT
Clinical Trials
The Renal Agenesis Fetal Therapy (RAFT) Trial
This study offers eligible pregnant patients with a fetal diagnosis of congenital bilateral renal agenesis (CoBRA) serial amnioinfusions with normal saline. All eligible patients will be offered intervention but may also elect expectant management.
Renal Anhydramnios Fetal Therapy (RAFT) Trial
The Renal Anhydramnios Fetal Therapy (RAFT) study is testing an experimental treatment for mothers and their babies affected by early pregnancy renal anhydramnios (EPRA). The study seeks to determine whether repeated injections of fluid (amnioinfusions) into the uterus can reverse the effects of EPRA such that affected babies have enough lung function to survive outside the womb.
Selected Publications
View all on PubMed
Jelin EB, Etemadi M, Encinas J, Schecter SC, Chapin C, Wu J, Guevara-Gallardo S, Nijagal A, Gonzales KD, Ferrier WT, Roy S, Miniati D. Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2011 Jun;46(6):1150-7. doi: 10.1016/j.jpedsurg.2011.03.049. PubMed PMID: 21683214; PubMed Central PMCID: PMC3128884.
Leeds IL, Boss EF, George JA, Strockbine V, Wick EC, Jelin EB. Preparing enhanced recovery after surgery for implementation in pediatric populations. J Pediatr Surg. 2016 Dec;51(12):2126-2129. doi: 10.1016/j.jpedsurg.2016.08.029. Epub 2016 Sep 5. PubMed PMID: 27663124; PubMed Central PMCID: PMC5373552
Jelin E, Hirose S, Rand L, Curran P, Feldstein V, Guevara-Gallardo S, Jelin A, Gonzales K, Goldstein R, Lee H. Perinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin. Fetal Diagn Ther. 2010;27(3):138-41. doi: 10.1159/000295176. Epub 2010 Mar 9. PubMed PMID: 20215730
Seravalli V, Jelin EB, Miller JL, Tekes A, Vricella L, Baschat AA. Fetoscopic tracheal occlusion for treatment of non-isolated congenital diaphragmatic hernia. Prenat Diagn. 2017 Oct;37(10):1046-1049. doi: 10.1002/pd.5139. Epub 2017 Sep 10. PubMed PMID: 28891233
Ladd MR, Jelin EB. The Pediatric Surgeon’s Role in Prenatal Counseling. Current Treatment Options in Pediatrics. 2017 June; 3(2):77-97.
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