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Eili Y. Klein, M.A., Ph.D.

Headshot of Eili Y. Klein
  • Associate Professor of Emergency Medicine

Research Interests

Antimicrobial resistance; Influenza evolution; Pathogen competition across space and scale; Impact of antimicrobial drug resistance on ecology and epidemiology of disease; Economic epidemiology; Mathematical and theoretical ecology; Evolution of pathogen-host interactions. more


Dr. Klein is an assistant professor in the Department of Emergency Medicine. He is also a fellow at the Center for Disease Dynamics, Economics and Policy in Washington, D.C. Upon finishing his Ph.D. in ecology and evolutionary biology from Princeton University, Dr. Klein joined the Johns Hopkins faculty in 2012.

Dr. Klein’s research focuses on the role of individuals in the spread of infectious diseases. This area of research sits at the nexus of economics and epidemiology, and is premised on the idea of incorporating incentives for healthy behavior and attendant behavioral responses into an epidemiological context to better understand how diseases are transmitted. This nascent field of economic epidemiology is based on the idea of improving policy responses to epidemic diseases by giving policymakers and health care providers clear tools for thinking about how certain actions can influence the spread of disease transmission. The primary disease focus of Dr. Klein’s research is antimicrobial resistance and influenza.

Dr. Klein has authored numerous publications on the evolution and spread of antimicrobial drug resistance, with particular reference to the emergence of antibiotic and antimalarial drug resistance. Dr. Klein is actively involved in research efforts supported by the Hartwell Foundation that focus on using computational tools for predicting antigenic change in influenza viruses from season to season. Dr. Klein is also actively involved in work supported by the Bill and Melinda Gates Foundation to support ResistanceMap, a global survey of antibiotic resistance rates across the globe. more


  • Associate Professor of Emergency Medicine

Departments / Divisions



  • B.A.; Columbia University in the City of New York (New York) (1998)
  • M.A.; Johns Hopkins University (Maryland) (2005)
  • Ph.D.; Princeton University (New Jersey) (2012)

Research & Publications

Research Summary

Dr. Klein is actively involved in research efforts examining the ecology and epidemiology of antibiotic resistance in the United States, focusing on aspects of the emergence, spread, and economic impact of important pathogens such as methicillin-resistant Staphylococcus aureus, carbapenem-resistant Klebsiella pneumoniae, vancomycin-resistant enterococci, and Clostridium difficile. In addition, he is also actively engaged in understanding the impact of seasonal changes in antibiotic prescriptions on changes in resistance levels, and how the interaction between the hospital and the community influences different strains of resistance. Dr. Klein also has active research programs dealing with the emergence and spread of anti-malarial drug resistance as well as research on the role transboundary transmission of tuberculosis (TB), with a particular focus on drug-resistance forms of TB, plays in the epidemiology and economic impact of TB.

Selected Publications

View all on PubMed

Klein, Eili Y., Michael Makowsky, Megan Orlando, Erez Hatna, Nikolay P. Braykov, Ramanan Laxminarayan (2015) "Influence of provider and urgent care density across different socioeconomic strata on outpatient antibiotic prescribing in the USA" Journal of Antimicrobial Chemotherapy DOI: 10.1093/jac/dku563.

Broniatowski, David A., Eili Y. Klein, Valerie Reyna (2014) "Germs are Germs, and Why Not Take a Risk?: Patients' Expectations for Prescribing Antibiotics in an Inner City Emergency Department" Medical Decision Making 35(1):60-67.

Klein EY, Serohijos AWR, Choi J-M, Shakhnovich EI, Pekosz A (2014) "Influenza A H1N1 Pandemic Strain Evolution - Divergence and the Potential for Antigenic Drift Variants" PLoS ONE 9(4): e93632.

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