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Dorry Segev, M.D., Ph.D.

Dorry Lidor Segev, M.D., Ph.D.

Headshot of Dorry Segev
  • Associate Vice Chair for Research
  • Professor of Surgery
Male

Languages: English, Hebrew

Expertise

Abdominal Surgery, Incompatible Kidney Transplant, Kidney Transplant, Minimally Invasive Live Donor Surgery, Minimally Invasive Surgery, Pancreas Transplant, Transplant Surgery, Vascular Surgery ...read more

Research Interests

Disparities in access to transplantation; Outcomes after kidney, liver, and pancreas transplantation; Mathematical simulation, modeling, and optimization; Advanced biostatistical methods, decision analysis and Markov models; Kidney transplantation and renal failure in the elderly; Kidney paired donation (living donor kidney exchange); Incompatible Kidney Transplantation; Allocation of non-directed donors; Expanding utilization of expanded criteria organs; Donor-recipient matching; Gender disparities in transplantation; Organ preservation solutions; Decision-making algorithms for high infectious risk donors; Safety and long-term survival in living kidney donors ...read more

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Main Phone

410-502-5198

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410-464-6641
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+1-410-502-7683
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Locations

Johns Hopkins Outpatient Center

Appointment Phone: 410-502-5198
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 443-287-7789 | Fax: 410-510-1526

Background

Dorry Segev, MD, PhD, is the Marjory K. and Thomas Pozefsky Professor of Surgery and Epidemiology and Associate Vice Chair of Surgery at Johns Hopkins University. He is the founder and director of the Epidemiology Research Group in Organ Transplantation (ERGOT), the largest and most prolific group of its kind in the world. Dr. Segev was the first to demonstrate the survival benefit of incompatible kidney transplantation across the United States, and is responsible for the first HIV-to-HIV transplants in the United States. His NIH-funded research includes kidney exchange, desensitization, long-term donor risk, access to transplantation, expanding transplantation including HIV+ donors, geographic disparities, post-transplant outcomes, and the intersection between transplantation and gerontology. With a graduate degree in biostatistics, Dr. Segev focuses on novel statistical and mathematical methods for simulation of medical data, analysis of large healthcare datasets, and outcomes research. 

Dr. Segev has published nearly 500 peer-reviewed research articles, including 15 in JAMA, NEJM, and Lancet and over 150 in the American Journal of Transplantation. Reflecting this publication track record, he was recently awarded the American Society of Transplantation's Clinical Science Investigator Award. He is a current councilor of the American Society of Transplant Surgeons and former chair of the American Transplant Congress. His work has directly influenced policy, including two Congressional bills (the Norwood Act for kidney exchange and the HOPE Act for HIV-to-HIV transplants), and is regularly featured in widely read media including TIME magazine, Wall Street Journal, and the New York Times. 

Dr. Segev is most inspired by his role as a mentor, having mentored over 100 graduate students, residents, and faculty, and is the only general surgeon in the US funded by an NIH/NIDDK Mentoring Grant.

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Titles

  • Associate Vice Chair for Research
  • Director, Epidemiology Research Group in Organ Transplantation
  • Professor of Surgery

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Johns Hopkins University School of Medicine (1996)

Residencies

  • Surgery; Johns Hopkins University School of Medicine (2004)

Board Certifications

  • American Board of Surgery (General Surgery) (2007)

Research & Publications

Lab

Lab Website: Epidemiology Research Group in Organ Transplantation

Selected Publications

Segev, DL, Gentry SE, Warren DS, Reeb B, Montgomery RA. Kidney Paired Donation and optimizing the use of live donor organs. JAMA. 2005 Apr 20; 293 (15) 1883-90.

Gentry SE, Segev DL, Montgomery RA. A comparison of populations served by Kidney Paired Donation and List Paired Donation. Am J Transplant. 2005 Aug; 5(8): 1914-21

Segev DL, Simpkins CE, Warren DS, King KE, Maley WR, Melancon JK, Cooper M, Kozlowski T, Montgomery RA. ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment. Am J 2005 Oct;5(10):2570-75.

Segev DL, Gentry SE, Melancon JK, Montgomery RA. Characterization of waiting times in a simulation of kidney paired donation. Am J Transplant. 2005 Oct; 5(10):2448-55.

Montgomery RA, Zachary AA, Ratner LE, Segev DL, Hiller JM, Houp J, Cooper M, Kavoussi L, Jarrett T, Burdick J, Maley WR, Melancon JK, Kozlowski T, Simpkins CE, Phillips M, Desai A, Collins V, Reeb B, Kraus E, Rabb H, Leffell MS, Warren DS. Kidney Paired Donation permits successful transplantation with incompatible live kidney donors. JAMA. 2005 Oct 5;294(13):1655-63.

Montgomery RA, Gentry SE, Marks WH, Warren DS, Hiller J, Houp J, Zachary AA, Melancon JK, Maley WR, Rabb H, Simpkins CE, Segev DL. Domino paired kidney donation: a strategy to make best use of live non-directed donation. Lancet. 2006 Jul 29;368:419-21.

Simpkins CE, Montgomery RA, Hawxby AM, Gentry SE, Locke JE, Warren DS, Segev DL. The Effect of Cold Ischemic Time on Live Donor Renal Transplantation: Is Organ Transport Feasible for Live Donors? Am J Transplant. 2006.

Segev DL, Gentry SE, Montgomery RA. Association between waiting times for deceased donor kidney transplantation and rates of live donation. Am J Transplant. 2007 Oct;7(10):2406-13.

Gentry SE, Segev DL, Simmerling M, Montgomery RA. Expanding kidney paired donation through voluntary participation by compatible donors. Am J Transplant. 2007 Oct;7(10):2361-70.

Segev DL, Maley WR, Simpkins CE, Locke JE, Montgomery RA, Nguyen GC, Thuluvath P. Minimizing risk associated with elderly liver donors by matching to preferred recipients. Hepatology. 2007 Dec;46(6):1907-18.

Segev DL, Simpkins CE, Thompson RE, Locke JE, Warren DS, Montgomery RA. Obesity impacts access to kidney transplantation. J Am Soc Nephrology. 2008 Feb;19(2):349-55.

Segev DL, Kucirka LM, Nguyen GC, Cameron AM, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR. Effect modification in liver allografts with prolonged cold ischemic time. Am J Transplant. 2008 Mar;8(3):658-66.

Segev DL, Sozio S, Shin EJ, Nazarian SM, Nathan H, Thuluvath PJ, Cameron AM, Montgomery RA, Maley WR. Steroid avoidance in liver transplantation: meta-analysis and meta-regression of randomized trials. Liver Transplantation. 2008 Apr;14(4):512-25.

Segev DL, Montgomery RA. Regional and Racial Disparities in the Use of Live Non-Directed Kidney Donors. Am J Transplant. 2008 May;8(5):1051-5.

Segev DL, Kucirka LM, Gentry SE, Montgomery RA. Current practice of kidney paired donation in the United States. Transplantation. 2008 Aug 27;86(4):502-10.

Montgomery RA, Katznelson S, Bry WI, Zachary AA, Houp J, Hiller JM, Shridharani S, John D, Singer AL, Segev DL. Successful three-way kidney paired donation with cross-country live donor organ transport. Am J Transplant. 2008 Oct;8(10):2163-8.

Segev DL, Thompson RE, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR. Prolonged waiting times for liver transplantation in obese patients. Ann Surg. 2008 Nov;248(5):863-870.

Stewart ZA, Cameron AM, Signer AL, Dagher NN, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in pancreas transplantation. Am J Transplant. 2009 Jan;9(1):217-221.

Locke JE, Montgomery RA, Warren DS, Segev DL. Renal transplantation in HIV-positive recipients: long-term outcomes and risk factors for graft loss. Arch Surg. 2009 Jan;144(1):83-86.

Stewart ZA, Cameron AM, Signer AL, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death. Am J Transplant. 2009 Feb;9(2):286-293.

Kucirka LM, Alexander C, Namuyinga R, Hanrahan C, Montgomery RA, Segev DL. Viral nucleic acid testing (NAT) and OPO-level disposition of CDC high-risk donor organs. Am J Transplant. 2009 Mar;9(3):620-8.

Kucirka LM, Namuyinga R, Hanrahan C, Montgomery RA, Segev DL. Formal policies and special informed consent are associated with higher provider utilization of CDC high-risk donor organs. Am J Transplant. 2009 Mar;9(3):629-35.

Lonze BE, Warren DS, Shah A, Stewart ZA, Dagher NN, Singer AL, Montgomery RA, Segev DL. Kidney transplantation in previous heart or lung recipients. Am J Transplant. 2008 Mar;9(3):578-85.

Segev DL, Kucirka LM, Oberai PC, Parekh RS, Boulware LE, Powe NR, Montgomery RA. Age and comorbidities are effect modifiers of gender disparities in renal transplantation. J Am Soc Nephrology. 2009 Mar;20(3):621-8.

Rees MA, Jopke JE, Pelletier RP, Segev DL, Rutter ME, Fabrega AJ, Rogers J, Pankewycz OG, Hiller J, Roth AE, Sandholm T, Unver U, Montgomery RA. A non-simultaneous extended altruistic donor chain. NEJM. 2009 Mar 12;360(11):1096-101.

Stewart ZA, Lonze BE, Warren DS, Signer AL, Dagher NN, Montgomery RA, Segev DL. Histidine-Tryptophan-Ketoglutarate (HTK) is associated with reduced graft survival of deceased donor kidney transplants. Am J Transplant. 2009 May;9(5):1048-54.

Kucirka LM, Namuyinga R, Hanrahan C, Montgomery RA, Segev DL. Provider utilization of high-risk donor organs and nucleic acid testing: results of two national surveys. Am J Transplant. 2009 May;9(5):1197-204.

Gentry SE, Montgomery RA, Swihart BJ, Segev DL. The roles of dominos and never-ending altruistic donor chains in kidney paired donation. Am J Transplant. 2009 Jun;9(6):1330-6.

Thuluvath PJ, Maheshwari A, Thuluvath NP, Nguyen GC, Segev DL. Survival after liver transplantation for hepatocellular carcinoma in MELD and pre-MELD eras and the independent impact of HCV. Liver Transplantation. 2009 Jun 26;15(7):754-762.

Massie AB, Zeger SL, Montgomery RA, Segev DL. The effects of DonorNet 2007 on kidney distribution equity and efficiency. Am J Transplant. 2009 Jul;9(7):1550-7.

Stewart ZA, Locke JE, Montgomery RA, Singer AL, Cameron AM, Segev DL. ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis. Liver Transplantation. 2009 Jul 29;15(8):883-93.

Melancon JK, Kucirka LM, Boulware LE, Powe NR, Locke JE, Montgomery RA, Segev DL. Impact of Medicare coverage on disparities in access to simultaneous pancreas and kidney transplantation. Am J Transplant. 2009 Dec;9(12):2785-91.

Segev DL, Muzaale AD, Caffo B, Mehta S, Taranto SE, McBride MA, Montgomery RA. Short-term and long-term survival in a 15-year cohort of all live kidney donors in the United States. JAMA. 2010 Mar 10;303(10):959-66.

Grams ME, Womer KL, Ugarte RM, Desai NM, Montgomery RA, Segev DL. Listing for expanded criteria donor kidneys in older adults and those with predicted benefit. Am J Transplant. 2010 Apr;10(4):802-9.

Kucirka LM, Ros RL, Subramanian AK, Montgomery RA, Segev DL. Provider response to a rare but highly publicized transmission of HIV through solid organ transplantation. Arch Surg. In press.

Kayler LK, Segev DL. The impact of nonidentical ABO deceased-donor kidney transplantation on kidney utilization. Am J Kidney Dis. In press.

Kucirka LM, Singer AL, Ros RL, Montgomery RA, Dagher NN, Segev DL. Underutilization of hepatitis C positive kidneys for hepatitis C positive recipients. Am J Transplant. In press.

Activities & Honors

Honors

  • Inducted, American Society for Clinical Investigation, 2012
  • Mid-Level Faculty Award, American Society of Transplant Surgeons, 2012
  • Maryland Top 40 Professionals Under 40, Maryland Daily Record, 2010
  • New Key Opinion Leader, The Transplantation Society, 2009
  • John Merrill Award in Transplantation, American Society of Nephrology, 2009
  • Julius Jacobson Promising Investigator Award, American College of Surgeons, 2009
  • Clinical Scientist Development Award, Doris Duke Charitable Foundation, 2008
  • Dennis W Jahnigen Scholars Award, American Geriatrics Society, 2007
  • Vanguard Prize, American Society of Transplant Surgeons, 2006
  • Clinical Science Faculty Award, American Society of Transplantation, 2006
  • Science of Hope Medicine Compassion Award, Johns Hopkins Transplant Center, 2006

Videos & Media

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    Living Donor Kidney Transplant

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    Meet Our Expert: Dr. Dorry Segev

Recent News Articles and Media Coverage

Dr. Dorry Segev is one out of the four physicians featured in this article who began his career in a field other than medicine. Read about his journey.

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