Research Summary
Dr. Kraitchman's research interests are concentrated on non-invasive imaging and minimally invasive treatment of cardiovascular disease and cancer. She has been actively involved in developing new methods to image myocardial function and perfusion using MRI. Current research interests are aimed at determining the optimal timing and method of administration of stem cells for cardiac regeneration using non-invasive MR fluoroscopic delivery and imaging. MRI, X-ray, and radiolabeling techniques include novel microencapsulation techniques to label stem cells to determine the location, quantity and biodistribution of stem cells after delivery as well as to noninvasively determine the efficacy of these therapies in acute myocardial infarction, peripheral arterial disease, and non-ischemic dilated cardiomyopathy. Microencapsulation techniques are also used for enhanced stem cell engraftment.
She is also focused on the development of new animal models of human disease for noninvasive imaging studies and the development of promising new therapies in clinical trials for companion animals. Novel embolics are being studied for the treatment of brain, lung, and bone cancer in pets with spontaneously occurring disease. Recent veterinary clinical trials are focusing on the combination of immunotherapy with cryoablation for the treatment of bone cancer. In addition, low-cost devices for third world countries are being repurposed for the veterinary market to enhance therapies for pets.
Technology Expertise Keywords
Stem cell, veterinary imaging, cardiovascular, MRI, CT, PET, SPECT
Clinical Trial Keywords
obesity embolization interventional radiology
Clinical Trials
veterinary clinical trials
Selected Publications
View all on PubMed
Krimins R, Fritz J,Gainsburg L, Gavin P, Ihms EZ, Huso DL, Kraitchman DL. MR-Guided bone biopsy of a T11 vertebral body mass in a Rottweiler. J Amer Vet Med Assoc,2017 250(7):779-784
Weiss CR, Fu Y, Beh C, Hsu C, Kedziorek D, Shin EJ, Arepally A, Kraitchman DL. Bariatric arterial embolization with calibrated radiopaque microspheres and an anti-reflux catheter suppresses weight gain and appetite-stimulating hormones in swine. J Vasc Interv Radiol. 2020; 31(9): 1483-1491
Kraitchman D, Kamel I, Weiss C and Georgiades C. Elucidation of percutaneously accessible lymph nodes in swine: A large animal model for interventional lymphatic research. J Vasc Interv Radiol. 2017; 28:451–456
Lauer AM, El-Sharkawy AM, Kraitchman DL, Edelstein WA. “MRI acoustic noise can harm experimental and companion animals.” J Magn Reson Imaging. 2012 Sep;36(3):743-7. doi: 10.1002/jmri.23653.
Fu Y, Azene N, Ehtiati T, Flammang A, Gilson WD, Gabrielson K, Weiss CR, Bulte JW, Johnston PV, Kraitchman DL :X-ray fusion with magnetic resonance image-guidance of intrapericardial delivery of microencapsulated human mesenchymal stem cells in immunocompetent swine. Radiology, 2014 272(2):427-437.
