Danielle Gottlieb Sen, M.D., M.P.H., M.S.

Headshot of Danielle Gottlieb Sen
  • Director, Pediatric Cardiac Research
  • Assistant Professor of Surgery

Languages: English, French, Spanish


Adult Congenital Heart Disease, Aortic Coarctation, Atrial Septal Defects (ASD), Cardiothoracic Surgery, Congenital Heart Disease, Patent Ductus Arteriosus (PDA), Pediatric Aortic Stenosis, Pediatric Cardiac Surgery, Pediatric Congenital Heart Disease, Pediatric Heart Transplant, Pediatric Thoracic Surgery, Single Ventricle Heart Defect, Tricuspid Atresia, Ventricular Septal Defect ...read more

Research Interests

Cardiac and somatic growth in patients with congenital heart disease; single ventricle congenital heart disease and left side obstructive lesions ...read more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 443-287-1262
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Pediatric Cardiology, M2201
Baltimore, MD 21287
The Johns Hopkins Hospital (Main Entrance) - Google Maps


Dr. Danielle Gottlieb Sen is a pediatric and congenital cardiac surgeon practicing in Baltimore Maryland at Johns Hopkins Children's Center.  She serves as Director of Pediatric Cardiac Research and Director of Pediatric Surgery Quality & Outcomes Research. Additionally, she is an assistant professor of surgery at the Baltimore-based Johns Hopkins School of Medicine.

Dr. Gottlieb Sen's expertise includes surgical palliation and treatment of infants, children and adults with congenital heart disease. Her research is organized around the critical issue of cardiac and somatic growth in patients with congenital heart disease.

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  • Director, Pediatric Cardiac Research
  • Director, Pediatric Surgery Quality & Outcomes Research
  • Assistant Professor of Surgery

Departments / Divisions

  • Cardiac Surgery
  • Surgery - Pediatric Cardiac Surgery

Centers & Institutes



  • MD; University of California San Francisco School of Medicine (2002)


  • General Surgery; Massachusetts General Hospital (2011)
  • Thoracic Surgery; New York-Presbyterian/Columbia University Irving Medical Center (2013)


  • Congenital Cardiac Surgery; Boston Children's Hospital (2015)
  • Congenital Cardiac Surgery; New York-Presbyterian Morgan Stanley Children's Hospital (2014)

Board Certifications

  • American Board of Surgery (General Surgery) (2012)
  • American Board of Thoracic Surgery (Congenital Cardiac Surgery) (2018)
  • American Board of Thoracic Surgery (Thoracic and Cardiac Surgery) (2017)

Research & Publications

Research Summary

Dr. Gottlieb Sen's research focuses on cardiac and somatic growth in patients with congenital heart disease, developing new materials for cardiac surgery and wearable technologies for monitoring patients with congenital heart disease and genetic etiologies of congenital heart disease.

Selected Publications

View all on PubMed

Anderson BR, Kumar SR, Gottlieb Sen D, Liava’a MH, Hill KD, Jacobs JP et al., “The congenital heart technical skill study: rationale and design.” World J Pediatr Congenit Heart Surg 2019; 10(2):137-144.

Gottlieb Sen D, Halu A, Gorham J, Razzaque MA, Seidman J, Seidman C, Aikawa E. “Characterizing the Transcriptional Signature of Growth in Late Fetal Aortic Valve Development”. Annals of Thoracic Surgery 2018;106(6):1834-1840.

Angel PM, Baldwin HS, Gottlieb Sen D, Su YR, Mayer JE, Bichell D, Drake RR. “Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve.” Biochem Biophys Acta 2017;1865 (7): 927-935.

Matte GS, Connor KR, Toutenel NA, Gottlieb D, Fynn-Thompson F. “A modified EXIT-to-ECMO with optional reservoir circuit for use during an EXIT procedure requiring thoracic surgery.” J Extra Corpor Technol 2016;48(1):35-38.

Sen DG, Najjar M, Yilmaz B, Levasseur SM, Kalessan B, Quaegebeur JM, Bacha EA. “Aiming to preserve pulmonary valve function in tetralogy of Fallot repair: comparing a new approach to traditional management.” Pediatr Cardiol 2016: 37(5):818-25.

Activities & Honors


  • STS Leadership Academy, Society of Thoracic Surgeons, 2020
  • 2019 Women in Medicine Honoree, American Heart Association, 2019
  • Nina Starr Braunwald Award, 2018
  • New Orleans City Business Woman of the Year Award Nominee, 2017
  • AATS Leadership Academy, American Association for Thoracic Surgery, 2016
  • Mid-Career Investigator Award, American Association for Thoracic Surgery Foundation; Women in Thoracic Surgery, 2023


  • Society of Thoracic Surgeons


  • Women in Thoracic Surgery


  • Southern Thoracic Surgical Society


  • Thoracic Surgery Foundation

    Grant reviewer

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