- Assistant Professor of Oncology
Departments / Divisions
- Oncology - Division of Women's Malignancies
the role of the extracellular matrix in cancer metastasis; hypoxia and the tumor microenvironment; transcriptional regulation by hypoxia-inducible factors ...read more
Learn more about clinical trials at Johns Hopkins Medicine.
Gilkes DM, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. The EMBO journal. 2006;25(23):5614-25.
Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. Journal of Biological Chemistry. 2013;288(15):10819-29.
Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research. 2013;11(5):456-66.
Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer research. 2013;73(11):3285-96.
Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews Cancer. 2014;14(6):430-9.