the role of the extracellular matrix in cancer metastasis; hypoxia and the tumor microenvironment; transcriptional regulation by hypoxia-inducible factors ...read more
The Gilkes Lab is part of the Women's Malignancy Program at the Johns Hopkins School of Medicine. Our work is focused on the role of hypoxia in breast cancer. One of our main interests are some particular genetic alterations that happen under hypoxia. Breast cancer cells adapt to hypoxic conditions by increasing levels of hypoxia-inducible factors (HIFs), which induce the expression of multiple genes involved in angiogenesis, glucose utilization, resistance to oxidative stress, cell proliferation, resistance to apoptosis, invasion and metastasis. Breast cancer patients with increased HIF expression levels in their primary tumor biopsies are at increased risk of metastasis. This is an important finding since 90% of breast cancer deaths are the result of metastasis, primarily to the bone, liver, lung, and liver. We also team with breast cancer advocates to drive patient-informed research with the ultimate goal of preventing deaths due to breast cancer.
Lab Website: Gilkes Lab
Joe NS, Hodgdon C, Kraemer L, Redmond KJ, Stearns V, Gilkes DM. A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases. NPJ Breast Cancer. 2021;7(1):121. Available from: http://www.ncbi.nlm.nih.gov/pubmed/34521857.
Godet I, Mamo M, Thurnheer A, Rosen DM, Gilkes DM. Post-Hypoxic Cells Promote Metastatic Recurrence after Chemotherapy Treatment in TNBC. Cancers (Basel). 2021;13(21). Available from: http://www.ncbi.nlm.nih.gov/pubmed/34771673.
DiGiacomo JW, Godet I, Trautmann-Rodriguez M, Gilkes DM. Extracellular Matrix-Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer. Mol Cancer Res. 2021;19(1):136-49. Available from: http://www.ncbi.nlm.nih.gov/pubmed/33033110.
Mamo M, Ye IC, DiGiacomo JW, Park JY, Downs B, Gilkes DM. Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner. Cancer Res. 2020;80(22):4998-5010. Available from: http://www.ncbi.nlm.nih.gov/pubmed/33023947.
Godet I, Shin YJ, Ju JA, Ye IC, Wang G, Gilkes DM. Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis. Nat Commun. 2019;10(1):4862. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31649238.
Microelectronic device layer deposited with multiple electrolytes.
Patent # US Patent # 6703712 |
Copper silicide passivation for improved reliability.
Patent # US Patent # 6869873 |
New cellular target may put the brakes on cancer's ability to spread, Science Daily (May 26, 2017)
Instead of starving a cancer, researchers go after its defenses by Laura Biel, ScienceNews (February 22, 2017)
11 TV Hill: Research is key to understanding breast cancer., WBAL TV (October 8, 2017)
New studies in breast cancer research, ABC7 WJLA (September 3, 2019)
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