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Daniele Marie Gilkes, Ph.D.

Headshot of Daniele Marie Gilkes
  • Assistant Professor of Oncology

Research Interests

the role of the extracellular matrix in cancer metastasis; hypoxia and the tumor microenvironment; transcriptional regulation by hypoxia-inducible factors ...read more

Background

Titles

  • Assistant Professor of Oncology

Departments / Divisions

  • Oncology - Division of Women's Malignancies

Education

Degrees

  • B.S.; University of Florida (Florida) (2000)
  • Ph.D.; University of South Florida Health Morsani College of Medicine (Tampa) (Florida) (2008)

Research & Publications

Clinical Trials

Learn more about clinical trials at Johns Hopkins Medicine.

Selected Publications

Gilkes DM, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. The EMBO journal. 2006;25(23):5614-25.

Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. Journal of Biological Chemistry. 2013;288(15):10819-29.

Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research. 2013;11(5):456-66.

Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer research. 2013;73(11):3285-96.

Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews Cancer. 2014;14(6):430-9.

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