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Christopher James VandenBussche, M.D., Ph.D.

Christopher James VandenBussche, M.D., Ph.D.

Headshot of Christopher James VandenBussche
  • Associate Director, Cytopathology Division
  • Associate Professor of Pathology
Male

Expertise

Bladder Cancer, Pathology

Research Interests

Genitourinary Cancer; Gynecologic Cancer

Locations

The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-1180

Johns Hopkins Outpatient Center

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-1180

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-1180

Background

Dr. Christopher VandenBussche is an Associate Professor of Pathology and Oncology at the Johns Hopkins University School of Medicine. He serves as the Associate Director of Cytopathology as well as the Program Director for the Cytopathology Fellowship.

Dr. VandenBussche’s research focuses on genitourinary and gynecologic cytopathology. He investigates molecular methods and digital image analysis techniques that may contribute to the earlier detection and treatment of cancer. His clinical research involves the international standardization of reporting in cytologic specimens. He led the pelvic washings subgroup of The International System for Reporting Serous Fluid Cytopathology as well as two subgroups for The Paris System for Reporting Urinary Cytology, including the subgroup on upper tract urothelial cancer.

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Titles

  • Associate Director, Cytopathology Division
  • Program Director, Cytopathology Fellowship
  • Associate Professor of Pathology
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD PhD; Georgetown University School of Medicine (2009)

Residencies

  • Anatomic and Clinical Pathology; Johns Hopkins University School of Medicine (2013)

Fellowships

  • Cytopathology; Johns Hopkins University School of Medicine

Board Certifications

  • American Board of Pathology (Anatomic & Clinical Pathology) (2013)
  • American Board of Pathology (Cytopathology) (2014)

Research & Publications

Research Summary

Dr. VandenBussche’s research focuses on genitourinary and gynecologic cytopathology. He investigates molecular methods and digital image analysis techniques that may contribute to the earlier detection and treatment of cancer. His clinical research involves the international standardization of reporting in cytologic specimens. He led the pelvic washings subgroup of The International System for Reporting Serous Fluid Cytopathology as well as two subgroups for The Paris System for Reporting Urinary Cytology, including the subgroup on upper tract urothelial cancer.

Selected Publications

Springer S, Chen C, Rodriguez Pena MDC, Li L, Douville C, Wang Y, Cohen J, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Papoli M, Kinde I, Afsari B, Tregnago AC, Bezerra SM, VandenBussche C, Fujita K, Ertoy D, Cunha IW, Yu L, Bivalacqua TJ, Grollman AP, Diaz LA, Karchin R, Danilova L, Huang C, Shun C, Turesky RJ, Yun BH, Rosenquist TA, Pu Y, Hruban RH, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Dickman KG, Netto GJ. Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. eLife. 2018. Mar 20;7. PMID: 29557778

Cowan ML, Rosenthal DL, VandenBussche CJ. Improved Risk Stratification for Patients with High Grade Urothelial Carcinoma Following Application of The Paris System for Reporting Urinary Cytology. Cancer Cytopathol.2017 Jun;125(6):427-434. PMID: 28272842

Zhang ML, Guo AX, VandenBussche CJ. Trained Morphologists Overestimate the Nuclear-to-Cytoplasmic Ratio. Cancer Cytopathol. 2016 Aug;124(8):552-64. PMID: 27159533

VandenBussche CJ, Allison DB, Graham MK, Charu V, Lennon AM, Wolfgang CL, Hruban RH, Heaphy CM. Alternative lengthening of telomeres and ATRX/DAXX loss can reliably be detected in fine needle aspirates of pancreatic neuroendocrine tumors. Cancer Cytopathol. 2017 Jul;125(7):544-551. PMID: 28371511

Ooki A, Del Carmen Rodriguez Pena M, Marchionni L, Dinalankara W, Begum A, Hahn NM, VandenBussche CJ, Rasheed ZA, Mao S, Netto GJ, Sidransky D, Hoque MO. YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells. Cancer Res. 2018 Jan 1;78(1):168-181. PMID: 29180467.

Academic Affiliations & Courses

Graduate Program Affiliation

Pathobiology

Activities & Honors

Honors

  • Resident Teaching Award (AP Faculty), JHUSOM Pathology Department, 2015
  • Resident Teaching Award (AP Faculty), JHUSOM Pathology Department, 2020
  • Bob Gay Lecture Series Guest Speaker, ASCT Services, 2022
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