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Christopher James VandenBussche, M.D., Ph.D.

Headshot of Christopher James VandenBussche
  • Associate Director, Cytopathology Division
  • Associate Professor of Pathology


Bladder Cancer, Pathology


The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-1180

Johns Hopkins Outpatient Center

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-1180

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-1180


Dr. Christopher VandenBussche is an Associate Professor of Pathology and Oncology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include bladder cancer and pathology. Dr. VandenBussche serves as the Associate Director of the Division of Cytopathology and the Cytopathology Fellowship Program Director.

Dr. VandenBussche earned his M.D. and Ph.D. from Georgetown University School of Medicine. He completed his residency at Johns Hopkins and performed a fellowship in cytopathology at Johns Hopkins. more


  • Associate Director, Cytopathology Division
  • Program Director, Cytopathology Fellowship
  • Associate Professor of Pathology
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes



  • MD PhD; Georgetown University School of Medicine (2009)


  • Anatomic and Clinical Pathology; Johns Hopkins University School of Medicine (2013)


  • Cytopathology; Johns Hopkins University School of Medicine

Board Certifications

  • American Board of Pathology (Anatomic & Clinical Pathology) (2013)
  • American Board of Pathology (Cytopathology) (2014)

Research & Publications

Research Summary

Dr. VandenBussche’s research focuses on urinary cytopathology. In addition to clinical research in the area of bladder cancer, he is working on several genetic, molecular and immunological ancillary assays to improve diagnostic ability. 

He is also interested in the impact of policy changes and scientific advancements on both the practice of gynecologic cytopathology and the clinical and biological behavior of the human papillomavirus (HPV).

Selected Publications

VandenBussche CJ, Rosenthal DL, Olson MT. Adequacy in voided urine cytology specimens: the role of volume and a repeat void upon predictive values for high grade urothelial carcinoma. Cancer Cytopathol. In press.
Nguyen DN, Kawamoto S, Cimino-Mathews A, Illei PB, VandenBussche CJ. Metastatic metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration. Diagn Cytopathol. In press. PMID: 26238413

VandenBussche CJ, Cimino-Mathews A, Park BH MD, Emens LA, Tsangaris TN, Argani P. Reflex ER/PR/Her2 analysis of breast cancers in needle core biopsy specimens dramatically increases health care costs. Am J Surg Path 2015; 39(7):939-47. PMID: 25871620

Michailidi C, Hayashi M, Datta S, Sen T, Zenner K, Oladeru O, Brait M, Izumchenko E, Baras A, VandenBussche C, Argos M, Bivalacqua TJ, Ahsan H, Hahn NM, Netto GJ, Sidransky D, Hoque MO. Involvement of epigenetics and EMT related miRNA in arsenic induced neoplastic transformation and their potential clinical use. Cancer Prev Res 2015;8(3):208-21. PMID: 25586904

Onur I, Rosenthal DL, VandenBussche CJ. Atypical urothelial tissue fragments in noninstrumented voided urine specimens are associated with low but significantly higher rates of urothelial neoplasia than benign-appearing urothelial tissue fragments. Cancer Cytopathol 2015;123(3):186-192. PMID: 25586692

Onur I, Rosenthal DL, VandenBussche CJ. Benign-appearing urothelial tissue fragments in noninstrumented voided urine specimens are associated with low rates of urothelial neoplasia. Cancer Cytopathol 2015;123(3):180-185. PMID: 25586552

VandenBussche CJ, Illei PB, Lin M, Ettinger DS, Maleki Z. Molecular alterations in non-small cell carcinomas of the young. Hum Pathol 2014;45(12):2379-87. PMID: 25288236

Gurda GT*, VandenBussche CJ*, Yonescu R, Gonzalez-Roibon N, Ellis CL, Batista DA, Netto GJ. Saccrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status. Mod Pathol 2014; 27:562-8. PMID: 24051698. * authors contributed equally

VandenBussche CJ, Elwood H, Cimino-Mathews A, Illei PB, Warzecha HN. Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype. Hum Pathol 2013; 44(11):2487-93. PMID: 24029706.

VandenBussche CJ, Khouri N, Sbaity E, Tsangaris TN, Vang R, Tatsas A, Cimino-Mathews A, Argani P. Borderline atypical ductal hyperplasia/low grade ductal carcinoma in situ on breast needle core biopsy should be managed conservatively. Am J Surg Pathol. 2013; 37(6):913-23. PMID: 23598968.

VandenBussche CJ, Sathiyamoorthy S, Owens CL, Burroughs FH, Rosenthal DL, Guan H. The Johns Hopkins Hospital template for urologic cytology samples: Parts II and III-Improving the predictability of indeterminate results in urinary cytology samples: an outcomes and cytomorphologic study. Cancer Cytopathol 2012; 121(1):21-8. PMID: 23192913.

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