Dr. VandenBussche’s research focuses on genitourinary and gynecologic cytopathology. He investigates molecular methods and digital image analysis techniques that may contribute to the earlier detection and treatment of cancer. His clinical research involves the international standardization of reporting in cytologic specimens. He led the pelvic washings subgroup of The International System for Reporting Serous Fluid Cytopathology as well as two subgroups for The Paris System for Reporting Urinary Cytology, including the subgroup on upper tract urothelial cancer.
Springer S, Chen C, Rodriguez Pena MDC, Li L, Douville C, Wang Y, Cohen J, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Papoli M, Kinde I, Afsari B, Tregnago AC, Bezerra SM, VandenBussche C, Fujita K, Ertoy D, Cunha IW, Yu L, Bivalacqua TJ, Grollman AP, Diaz LA, Karchin R, Danilova L, Huang C, Shun C, Turesky RJ, Yun BH, Rosenquist TA, Pu Y, Hruban RH, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Dickman KG, Netto GJ. Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. eLife. 2018. Mar 20;7. PMID: 29557778
Cowan ML, Rosenthal DL, VandenBussche CJ. Improved Risk Stratification for Patients with High Grade Urothelial Carcinoma Following Application of The Paris System for Reporting Urinary Cytology. Cancer Cytopathol.2017 Jun;125(6):427-434. PMID: 28272842
Zhang ML, Guo AX, VandenBussche CJ. Trained Morphologists Overestimate the Nuclear-to-Cytoplasmic Ratio. Cancer Cytopathol. 2016 Aug;124(8):552-64. PMID: 27159533
VandenBussche CJ, Allison DB, Graham MK, Charu V, Lennon AM, Wolfgang CL, Hruban RH, Heaphy CM. Alternative lengthening of telomeres and ATRX/DAXX loss can reliably be detected in fine needle aspirates of pancreatic neuroendocrine tumors. Cancer Cytopathol. 2017 Jul;125(7):544-551. PMID: 28371511
Ooki A, Del Carmen Rodriguez Pena M, Marchionni L, Dinalankara W, Begum A, Hahn NM, VandenBussche CJ, Rasheed ZA, Mao S, Netto GJ, Sidransky D, Hoque MO. YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells. Cancer Res. 2018 Jan 1;78(1):168-181. PMID: 29180467.