Christine Anne Pratilas, M.D.

Headshot of Christine Anne Pratilas
  • Associate Professor of Oncology

Specializes in: Adolescents (12-18 years), Children (1-11 years), Infants (up to 1 year)



Bone Cancer, Clinical Trials, Ewing's Sarcoma, Medical Oncology, Melanoma, Osteosarcoma, Pediatric Cancer, Rhabdomyosarcoma, Sarcoma and Musculoskeletal Tumors, Soft Tissue Sarcoma more

Research Interests

oncogenes; BRAF; NF1; RAS; cancer cell signaling pathways; molecularly targeted therapy; RAF and MEK inhibitor therapy; pediatric sarcomas; pediatric phase I clinical trials more

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Main Phone

Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-8751
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, 11th Floor
Baltimore, MD 21287 map


Dr. Christine Pratilas is a pediatric medical oncologist at the Sidney Kimmel Comprehensive Cancer Center and Associate Professor of Oncology, Pediatrics & Cellular and Molecular Medicine at the Johns Hopkins University School of Medicine. She joined the Hopkins pediatric sarcoma team in 2014.

Dr. Pratilas received her undergraduate degree in Biology from Drew University in New Jersey and her medical degree from the Robert Wood Johnson Medical School (now Rutgers University), where she also completed her internship and residency from 1999 to 2002. From 2002 to 2005 she was a fellow in hematology and oncology in the Memorial Sloan Kettering Cancer Center (MSKCC) Department of Pediatrics, and in the Department of Pediatric Hematology and Oncology at New York Weill Cornell Medical Center. She worked for three years as a postdoctoral research fellow in Dr. Neal Rosen’s Molecular Oncogenesis Laboratory at MSKCC. 

From 2006 to 2014 she was attending in Pediatric Oncology at MSKCC, initially as a member of the Developmental Therapeutics & Lymphoma team. In 2011 she began her specialization in the care of pediatric sarcoma patients.

During her years in the lab of Dr. Rosen, a distinguished molecular pharmacologist and cell biologist, Dr. Pratilas focused her research on signal transduction, which involves figuring out how a cell’s internal molecular pathways work, and how those pathways can be molecularly controlled. This knowledge is the basis for developing promising new molecularly targeted cancer therapies, which is the focus of Dr. Pratilas’s research. One of her most important contributions to date has been to advance our understanding of how certain proteins that can be mutated in cancer, known as RAF kinases, affect a cancer cell’s behavior.

Dr. Pratilas continues her research on signal transduction pathways, concentrating on pediatric sarcomas, in order to develop novel therapeutics for children with these tumors. more


  • Associate Professor of Oncology
  • Associate Professor of Pediatrics

Departments / Divisions

Centers & Institutes



  • MD; Pediatrics; Rutgers - Robert Wood Johnson Medical School (1999)


  • Pediatrics; Rutgers - Robert Wood Johnson University Hospital (2002)


  • Hematology and Oncology; Memorial Sloan-Kettering Cancer Center (2005)

Board Certifications

  • American Board of Pediatrics (Pediatric Hematology-Oncology) (2006)
  • American Board of Pediatrics (Pediatrics) (2002)

Research & Publications

Clinical Trial Keywords

Molecularly targeted therapy; pediatric cancer; solid tumor

Clinical Trials


10/12/10 Awarded, Biomarkers for Cancer Treatment - U.S. Patent No. 7,812,143 B2; Inventors: Pratilas, C; Rosen, N
Patent # U.S. Patent No. 7,812,143 B2 | 10/12/2010

Academic Affiliations & Courses

Graduate Program Affiliation

Cellular and Molecular Medicine

Activities & Honors


  • Young Investigator Award, Melanoma Research Alliance, 2011
  • ASCO Foundation Young Investigators Award, 2004
  • AACR Scholar-in-Training Award, 2004
  • Doris Duke Award, MSKCC, 2004
  • Medical Society Scholarship, Morris County, NJ, 1997
  • Magna cum laude, Phi Beta Kappa, Drew University, 1995
  • Merit Scholarship, Drew University, 1992 - 1995
  • Edward Bloustein Garden State Scholarship, New Jersey, 1992 - 1995


  • American Association for Cancer Research, 2003
  • American Society of Clinical Oncology, 2003
  • Children’s Oncology Group, 2008
  • AACR Pediatric Cancer Working Group, 2012

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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