Dr. Ho’s laboratory studies the pathogenesis and treatment of diabetic neuropathy, with a particular focus on the impact of the skin microenvironment. Previous research in diabetic neuropathy has largely focused on sensory neurons. Few studies have explored how skin changes caused by diabetes may accelerate the damage of the sensory nerve fibers, which are embedded in the skin. Skin and cutaneous sensory nerves form the neuro-immuno-endocrine circuitry, the disruption of which may underlie the pathogenesis of diabetic neuropathy. Dr. Ho’s research focuses on the role of skin-derived molecules such as neurotrophic factors and inflammatory cytokines in the maintenance of the cutaneous sensory nerve fibers and in the development of neuropathic pain. Her laboratory also develops novel therapeutics for diabetic neuropathy.
Kuehn ED, Meltzer S, Abraira VE, Ho C, Ginty DD. Tiling and Somatotopic Alignment of Mammalian Low-Threshold Mechanoreceptors. Proc Natl Acad Sci U S A 2019; 116: 9168-9177. PMID: 30996124
Ho C, Ames HM, Tipton A, Vezina G, Liu JS, Scafidi J, Torii M, Rodriguez FJ, du Plessis A, DeBiasi RL. Differential neuronal susceptibility and apoptosis in congenital Zika virus infection. Ann Neurol 2017; 82: 121-127. PMID: 28556287
Driggers RW*, Ho C*, Korhonen EM*, Kuivanen S*, Jaaskalainen AJ, Smura T, Rosenberg A, Hill DA, DeBiasi DL, Vezina G, Timofeev J, Rodriguez FJ, Levanov L, Razak J, Iyengar P, Hennenfent A, Kennedy R, Lanciotti R, du Plessis A, Vapalahti O. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Eng J Med 2016; 374: 2142-2151 PMID: 27028667 (* equal contribution)
Ho C, Mobley BC, Gordish-Dressman H, VandenBussche CJ, Mason GE, Bornhorst M, Esbenshade AJ, Tehrani M, Orr BA, LaFrance DR, Devaney JM, Meltzer BW, Hofherr SE, Burger PC, Packer RJ, Rodriguez FJ. A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation. Acta Neuropathol 2015; 130:575-585. PMID:26264609
Rutlin M*, Ho C*, Abraira VE*, Cassidy C, Woodbury CJ, Ginty DD. The cellular and molecular basis of direction selectivity of Aδ-LTMRs. Cell 2014; 159:1640-1651. PMID: 25525881 (* equal contribution)