Charles Julian Lowenstein, M.D.

Headshot of Charles Julian Lowenstein
  • Michel Mirowski, M.D. Professor of Cardiology
  • Professor of Medicine

Specializes in: Adults (18+ years)


Adult Congenital Heart Disease, Cardiology, Cardiovascular Disease, Cardiovascular Disease Prevention, General Cardiology, Heart Disease more

Research Interests

Vascular biology

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Outside of Maryland & Washington D.C.

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Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 443-997-0270
10755 Falls Road
Pavilion I Suite 360
Lutherville, MD 21093 map


Charles Lowenstein, M.D., is a cardiologist in Baltimore, Maryland. He also serves as director of the Division of Cardiology and co-director of the Johns Hopkins Heart and Vascular Institute.

Dr. Lowenstein originally came to Johns Hopkins as a cardiology fellow in 1991 after completing his medical residency at Massachusetts General Hospital and a research fellowship at the Massachusetts Institute of Technology. In 1993, he joined the Johns Hopkins faculty and helped lead the Ciccarone Center for the Prevention of Heart Disease until he was recruited in 2009 to become the chief of cardiology and director of the Aab Cardiovascular Research Institute at the University of Rochester School of Medicine and Dentistry. In 2020 he was hired to lead the Division of Cardiology at Hopkins.

He has served on the NIH Atherosclerosis and Inflammation Cardiovascular Sciences study section, and is a member of the Sarnoff Cardiovascular Research Foundation, an organization that funds medical student research. Dr. Lowenstein’s research focuses on vascular biology, exploring molecular mechanisms of vascular inflammation and thrombosis. more


  • Michel Mirowski, M.D. Professor of Cardiology
  • Director, Division of Cardiology
  • Professor of Medicine
  • Professor of Genetic Medicine

Departments / Divisions



  • MD; Harvard Medical School (1986)


  • Medicine; Massachusetts General Hospital (1989)


  • Johns Hopkins University School of Medicine (1993)
  • Medicine; Massachusetts General Hospital (1991)

Board Certifications

  • American Board of Internal Medicine (Cardiovascular Disease) (2004)
  • American Board of Internal Medicine (Internal Medicine) (1989)

Research & Publications

Research Summary

Venous thromboembolism is a major cause of morbidity and mortality. Thrombosis can be caused by acquired or inherited factors, but the genetic contribution to thrombosis is not well defined. Genome wide association studies have recently uncovered new pathways that cause thrombotic disease in humans.

The Lowenstein Lab uses human genetics to discover and characterize novel genes that regulate thrombosis and hemostasis. We collaborate with genetic epidemiologists who perform GWAS to identify genetic variants linked to vascular inflammation or thrombosis. We then characterize genetic loci linked to vascular inflammation or thrombosis. These approaches have revealed new pathways in endothelial cells and platelets that contribute to thrombosis and may lead to novel therapies to prevent abnormal bleeding and thrombosis.

Current Projects:

  • Genetic causes of venous thromboembolism
  • Genetic causes of abnormal endothelial activation
  • Epigenetic regulation of coagulation factor production

Research Areas: vascular inflammation, thrombosis, hemostasis

Activities & Honors


  • Peter Dolphin Award, 2005
  • Sir William Osler Young Investigator Award, 2003
  • Young Investigators Conference on Atherosclerosis Award, 2000


  • NIH Atherosclerosis and Inflammation Cardiovascular Sciences study section
  • Sarnoff Cardiovascular Research Foundation
  • InterUrban Clinical Club
  • American Society for Clinical Investigation

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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