Charlene Gamaldo, M.D.

Charlene Edie Gamaldo, M.D.

Headshot of Charlene Gamaldo
  • Professor of Neurology


Neurology, Sleep Apnea, Sleep Disorders, Sleep Medicine, Snoring Disorders more

Research Interests

Sleep Disorders

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Johns Hopkins Center for Sleep and Wellness

Appointment Phone: 800-937-5337
11085 Little Patuxent Parkway
Medical Arts Building, Suite 210
Columbia, MD 21044 map
Phone: 800-937-5337 | Fax: 410-367-2419


Dr. Charlene Gamaldo is a sleep specialist in the Johns Hopkins Center for Sleep at Johns Hopkins Howard County Medical Center. Her research interests are in the area of sleep medicine, specifically investigating the co-morbid health consequences of chronic sleep deprivation.

Dr. Gamaldo received her bachelors degree from the University of Virginia in Charlottesville. She then earned her medical degree from The George Washington University School of Medicine and completed an internship at the Greater Baltimore Medical Center. After her neurology residency at the University of North Carolina Hospital, Dr. Gamaldo became the first neurology clinical sleep research fellow at Johns Hopkins, where she served as a co-investigator on several studies evaluating the pathophysiology of restless legs syndrome (RLS). more


  • Professor of Neurology
  • Joint Appointment in Psychiatry and Behavioral Sciences
  • Professor of Anesthesiology and Critical Care Medicine

Departments / Divisions

Centers & Institutes



  • MD; The George Washington University School of Medicine (2000)


  • Neurology; UNC Medical Center (2004)


  • Neurology; Johns Hopkins University School of Medicine (2006)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2005)
  • American Board of Psychiatry and Neurology (Sleep Medicine) (2009)

Research & Publications

Research Summary

Dr. Gamaldo's research interests include studying the impact of sleep on manifestation and progression of neurological diseases.  Looking at this relationship between sleep and disease progression in HIV will serve as the foundation for future work focused on the impact of sleep loss on other aspects of neurobiological function. By conducting this research, it is serving as a model for sleep research using the efforts of a diverse group of interdisciplinary collaborators and as a result has led to ongoing and evolving research projects that now include a growing list of collaborators (Neurology, OB/Gyn, Psychiatry, Urology, School of Nursing and Public Health along with the National Institute on Aging). The results of this study are suggesting that compromised sleep quality and duration may have a significant impact on cognitive performance in HIV+ individuals. Learn more about this study.

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Clinical Trials

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Selected Publications

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1. Pearson VE, Allen RP, Dean T, Gamaldo CE, Lesage SR, Earley CJ. Cognitive deficits associated with restless legs syndrome (RLS). Sleep Med. 2006 Jan; 7(1):25-30.

2. Gamaldo CE, Benbrook AR, Allen RP, Scott JA, Henning WA, Earley CJ. Childhood and adult factors associated with restless legs syndrome (RLS) diagnosis. Sleep Med. 2007 Nov;8(7-8):716-22.

3. Gamaldo CE, Benbrook AR, Allen RP, Oguntimein O, Earley CJ. A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS). Sleep Med. 2007 Sep 13;

4. Pearson VE, Gamaldo CE, Allen RP, Lesage S, Hening WA, Earley CJ. Medication use in patients with restless legs syndrome compared with a control population. Eur J Neurol. 2008 Jan; 15(1):16-21.

5. Gamaldo CE, Benbrook AR, Allen RP, Oguntimein O, Earley CJ. Evaluating daytime alertness in individuals with restless legs syndrome (RLS) compared to sleep restricted controls. Sleep Med. 2008 Jan 26;

6. Bolla KI, Lesage S, Gamaldo C, Neubauer D, Funderburk F, Cadet JL, David P, Verdejo-Garcia A, Benbrook A. Sleep disturbance in heavy marijuana users. Sleep. 2008 Jun 1;31(6):901-8.

7. Gamaldo CE, Salas R. Sleep medicine education: are medical schools and residency programs napping on the job? Nat Clin Pract Neurol. 2008 Jun;4(6):344-45.

8. Gamaldo,C, Benbrook,AR, Allen,RP, Oguntimein, O, Earley, CJ. Evaluating Daytime Alertness in individuals with Restless Legs Syndrome (RLS) compared to sleep restricted controls. Sleep Medicine. 2009 10:134-138.

9. Salas RE, Gamaldo CE, Allen RP, Earley CJ. Quiescegenic Nocturnal Dyskinesia: A restless legs syndrome (RLS) variant or a new syndrome? Sleep Med. 2008 Aug 13. [Epub ahead of print]

10. Salas,RE, Allen,RP, Earley,CJ, Gamaldo,CE. A Case of Compulsive Behaviors Observed in a RLS Patient Treated with a Dopamine Agonist. Sleep, accepted for publication 2009.

11. Salas,RE, Allen,RP, Earley,CJ, Gamaldo,CE. Drug hoarding: A case of atypical dopamine dysregulation syndrome in a RLS patient. Movement Disorders, 2009 Jan 9. [Epub ahead of print]

12.Gamaldo,C, Benbrook,AR, Allen,RP, Oguntimein, O, Earley, CJ. Evaluating Daytime Alertness in individuals with Restless Legs Syndrome (RLS) compared to sleep restricted controls. Sleep Medicine. 2009 10:134-138.

13. Bolla KI, Lesage SR, Gamaldo CE, Neubauer DN, Wang N, Funderburk FR, Allen RP, David PM, Cadet JL. Polysomnogram Changes in Marijuana Users Reporting Sleep Disturbances during Prior Abstinence. Sleep Medicine. 2010 Oct;11(9):882-9.

14. Earley C, Kuwabara H, Wong D, Gamaldo C, Salas R, Brasic J, Ravert H, Dannals R, Allen R, The Dopamine Transporter is Decreased in the Striatum of Subjects with Restless Legs Syndrome. Sleep, 2011 Mar 1; 34(3): 341-7.

Activities & Honors


  • KANE-KING-DODEK , Obstetrical Honor Society, 2000
  • Co-chief Resident, UNC Neurology Department, 2003 - 2004
  • Resident Scholarship Award, AAN , 2004
  • Doris Duke Clinical Scientist Development Award, Johns Hopkins University, 2008
  • Best in Sleep-Physician 2011,, 2011
  • Clerkship Director Innovation Award, American Academy of Neurology, 2015
  • Selected for the Transforming Leaders Program, American Academy of Neurology
  • Nominated for the AAN Board of Directors, American Academy of Neurology, 2017


  • American Academy of Neurology, 2002
  • American Academy of Sleep Medicine, 2004
  • World Association of Sleep Medicine, 2005

Professional Activities

  • Assistant Director, The Johns Hopkins Hospital, 2007
  • Co-Director, Johns Hopkins Hospital Neurology Resident and Neurophysiology Fellow, 2008
  • Director, Johns Hopkins University, 2011
  • Medical Director, Johns Hopkins Sleep Disorders Center, 2010

Videos & Media

  • Play Video:

    Aging and Sleep Problems

  • Play Video:

    Sleep Apnea Diagnosis and Treatment

  • Play Video:

    Restless Legs Syndrome and Sleep - Diagnosis and Treatments

  • Play Video:

    Common Sleep Problems

  • Play Video:

    Delivering Sleep Health, Wellness and Medical Education in the Era of Covid-19

Recent News Articles and Media Coverage

How to Handle a Sleep Walker, New York Times Magazine (08/11/17)

New app helps doctors diagnose sleep disorders, the Johns Hopkins News-Release (03/30/2015)

Johns Hopkins doctors develop app to identify sleep disorders, Baltimore Business Journal (03/31/2015)

A new study's surprising news about how many Americans sleepwalk, Baltimore Sun (8/8/2012)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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