Caitlin O'Brien, M.D., M.P.H.

Headshot of Caitlin O'Brien
  • Assistant Professor of Anesthesiology and Critical Care Medicine

Languages: English, Spanish


Pediatric Critical Care Medicine

Research Interests

Cardiopulmonary resuscitation; brain injury after cardiac arrest more


The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building
Baltimore, MD 21287 map
Phone: 410-955-6412


Dr. Caitlin O’Brien is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. She is an attending physician in the pediatric intensive care unit where she cares for children with neurologic, traumatic, and medical illnesses. She serves as the Co-Director of the Pediatric Neurocritical Care Program and Medical Director of the Hopkins Outreach for Pediatric Education (HOPE) Center.

Dr. O’Brien currently divides her time between clinical practice and research. Her research focuses on improving neurologic outcomes after pediatric cardiac arrest. Current projects include understanding mechanisms of hypoxic-ischemic injury in the developing brain, the use of post-arrest pharmacologic therapy to improve outcomes, and use of physiologic feedback during active resuscitation.

Dr. O’Brien received her undergraduate degree in biology from the University of Notre Dame and her medical degree from Georgetown University School of Medicine. She completed her residency in combined internal medicine-pediatrics at the Mount Sinai Hospital in New York City, where she also earned a master of public health. Dr. O’Brien completed fellowship training in pediatric critical care medicine at the Johns Hopkins University and completed additional research training while supported on a T32 fellowship. She joined the Johns Hopkins faculty in 2017. more


  • Assistant Professor of Anesthesiology and Critical Care Medicine

Departments / Divisions



  • MD; Georgetown University School of Medicine (2010)


  • Medicine and Pediatrics; The Mount Sinai Hospital (2014)


  • Pediatric Critical Care Medicine; Johns Hopkins University School of Medicine (2017)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (2014)
  • American Board of Pediatrics (Pediatric Critical Care Medicine) (2018)
  • American Board of Pediatrics (Pediatrics) (2015)

Research & Publications

Selected Publications

O’Brien CE, Reyes M, Santos PT, Heitmiller SE, Kulikowicz E, Kudchadkar SR, Lee JK, Hunt EA, Koehler RC, Shaffner DH.  A pilot study to compare the use of end-tidal carbon dioxide-guided and diastolic blood pressure-guided chest compression delivery in a swine model of neonatal asphyxial cardiac arrest.  J Am Heart Assoc. 2018;7:e009728

O'Brien CE, Santos PT, Kulikowicz E, Reyes M, Koehler RC, Martin LJ, Lee JK.  Hypoxia-Ischemia and hypothermia independently and interactively affect neuronal pathology in neonatal piglets with short-term recovery.  Dev Neurosci. 2019; 41(1-2): 17-33

O'Brien CE, Santos PT, Reyes M, Adams S, Hopkins CD, Kulikowicz E, Hamrick JL, Hamrick JT, Lee JK, Kudchadkar SR, Hunt EA, Koehler RC, Shaffner DH.  Association of diastolic blood pressure with survival during paediatric cardiopulmonary resuscitation. Resuscitation. 2019; 143: 50-56

O'Brien CE, Santos PT, Kulikowicz E, Lee JK, Koehler RC, Martin LJ.  Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine.  BMC Neurosci. 2020 Oct 31;21(1):43

Activities & Honors


  • American Heart Association
  • Society for Critical Care Medicine
  • Society for Neuroscience

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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